Full-range Fourier-domain Doppler optical coherence tomography method

Abstract

The invention provides a full-depth Fourier-range Doppler optical coherence tomography method which adopts an optical-fiber frequency domain optical coherence tomography system. The method is as follows: a complex tomographic signal obtained by the sinusoidal phase-modulation complex frequency domain optical coherence tomography method is used to calculate a Doppler signal so as to obtain a full-range structural tomographic image and a full-range Doppler image. The invention adopts the mode of synchronization of phase modulation and lateral scanning, so as to reduce the time of data acquisition and is enabled to be relatively suitable for in vivo imaging of a biological sample. The impact of a mirror image is eliminated to allow a to-be-test sample to be always in a region with a relatively-high signal-to-noise ratio in the system, and the modulation amplitude of sinusoidal phase modulation is small and close to a position of zero optical path difference all the time, so that a relatively-high velocity detection sensitivity can be obtained within the whole image. A full-depth Doppler image with a relatively-high velocity detection sensitivity can be obtained while a full-depth tomographic structural image with a relatively-high signal-to-noise ratio is obtained.

Description

technical field [0001] The present invention relates to frequency-domain optical coherence tomography (Fourier-Domain Optical Coherence Tomography, referred to as FD-OCT), in particular to a full-depth frequency-domain Doppler optical coherence tomography method. Background technique [0002] Optical coherence tomography (OCT for short) is a non-invasive, high-resolution optical tomography technique that has broad application prospects in the fields of biological research and clinical medicine. Doppler Optical Coherence Tomography (DOCT for short) is a functional extension of OCT technology, which combines OCT with Doppler imaging to form a new biomedical optical imaging technology. While non-invasively obtaining high-resolution tomographic structures in biological tissues, this technology can also provide dynamic information such as depth-resolved blood flow in tissues. It has been used in human retinal microcirculation imaging and animal embryo cardiovascular development. ...

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Problems solved by technology

In 2010, P. Meemon et al. established a full-range FD-DOCT based on synchronous phase shifting using a dual interference signal receiving system (see prior art [1] P. Meemon, Kye-Sung Lee, and J.P. Rolland, "Doppler imaging with dual-detection full-range frequency domain optical coherence tomography”, Biomed.Opt.Express1(2), 537-552, 2010), the image elimination is performed without affecting the interference signal acquisition speed, however, this method increases The complexity of the experimental setup

However, this method adopts the asynchronous method of phase modulation and lateral scanning, which increases the acquisition time of interference signals, and is not suitable for biological imaging

In addition, this method only performs structural imaging, and does not combine with DOCT technology to obtain Doppler images of samples

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