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External skin preparation

A skin external preparation, carotene technology, applied in skin care preparations, cosmetic preparations, medical science and other directions, can solve the problems of hair elongation and thickening, telangiectasia, etc., and achieve high safety effects

Inactive Publication Date: 2013-12-18
JX NIPPON OIL & ENERGY CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these drugs have side effects such as hair growth and thickening, skin atrophy, capillary dilation, and purpura.

Method used

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  • External skin preparation
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Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0054] 〔Preparation Example 1〕Preparation of calendula erythrin free body, calendula xanthin free body and astaxanthin free body

[0055] Dried cells of Paracoccus carotinifaciens were subjected to extraction at room temperature using acetone. The obtained extract was concentrated with an evaporator, and the concentrate was separated into two layers. A hexane-chloroform (1:1) mixture was added to the concentrate, mixed well, and an organic solvent layer was obtained by liquid separation.

[0056] The obtained organic solvent layer was concentrated to dryness with an evaporator. The concentrated dry matter was dissolved in chloroform, and the carotenoids were separated with a silica gel column. Specifically, the fraction eluted with 300 mL of acetone:hexane (3:7) was further purified by HPLC (Shim-pack PRC-SIL, acetone:hexane (3:7)) to obtain a free form of marigoldin. Fractions eluted with acetone:hexane (5:5) were concentrated and allowed to stand at 4°C to obtain free asta...

Embodiment 1

[0058] [Example 1] Evaluation of Singlet Oxygen Scavenging Activity of Carotenoids

[0059] The singlet oxygen scavenging activity of carotenoids (free form of calendula xanthin, free form of marigold xanthin, and free form of astaxanthin) was investigated as follows.

[0060] 1-1. Experimental method

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Abstract

The purpose of the present invention is to provide a very safe external skin preparation capable of mitigating or preventing wrinkles. Specifically, the present invention relates to an external skin preparation containing a carotenoid as an active ingredient.

Description

technical field [0001] The present invention relates to skin external preparations such as cosmetics for wrinkle improvement and wrinkle prevention. Background technique [0002] Skin aging such as wrinkles, blemishes, dull complexion, sagging, and loss of tension caused by aging, dryness, and sunlight (ultraviolet rays), etc., through the decrease of collagen and elastin in the dermis of the skin, stickiness It is caused by the reduction of sugar, damage to cells by ultraviolet rays, etc. In particular, deeply inscribed rhombus-shaped wrinkles caused by ultraviolet rays are called photoaging. [0003] Currently, in the treatment of photoaging, external treatments such as steroid agents and indomethacin that inhibit the release of histamine are performed. However, these medicines have side effects such as elongation and thickening of hair, shrinkage of skin, dilation of capillaries, and purpura. [0004] In addition, for example, prevention of wrinkle formation by histami...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/67A61Q19/08
CPCA61K8/0216A61K8/23A61Q11/00A61Q19/00A61K8/35A61Q19/08A61K8/9789
Inventor 真冈孝至石桥卓
Owner JX NIPPON OIL & ENERGY CORP