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Compound phloroglucinol freeze-dried orally-disintegrating tablet and preparation method

A technology of oral disintegrating tablets and phloroglucinol, which is applied in the directions of pharmaceutical formulations, medical preparations of inactive ingredients, and pill delivery, etc., to achieve the effects of high porosity, less amount of auxiliary materials, and good taste.

Active Publication Date: 2014-01-08
SHOUGUANG FUKANG PHARMA +2
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0009] At present, there is no relevant literature report on the preparation of compound phloroglucinol freeze-dried orally disintegrating tablets by freeze-drying at home and abroad

Method used

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  • Compound phloroglucinol freeze-dried orally-disintegrating tablet and preparation method
  • Compound phloroglucinol freeze-dried orally-disintegrating tablet and preparation method

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Embodiment Construction

[0023] Hereinafter, the present invention will be described in further detail by way of examples and comparative examples.

[0024] Prepare compound phloroglucinol freeze-dried orally disintegrating tablets according to the ingredients and quantities shown in Table 1, and the specific methods are as follows:

[0025] Dissolve phloroglucinol and trimethylphloroglucinol in aqueous solution, add sodium alginate, xylooligosaccharides, and stevioside to dissolve, and make solution A; add corn protein into an appropriate amount of 75% ethanol aqueous solution to dissolve , to make solution A; mix solution A and solution B, add an appropriate amount of water to dilute, and mix well; divide into molds with appropriate volumes, freeze at low temperature, put them into a freeze dryer to evacuate, and sublimate to The material is completely dried, sealed and packaged into freeze-dried tablets.

[0026] Table 1

[0027]

[0028]

[0029] In order to better understand the present i...

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Abstract

The invention provides a compound phloroglucinol freeze-dried orally-disintegrating tablet and a preparation method. The compound phloroglucinol freeze-dried orally-disintegrating tablet contains phloroglucinol and trimethoxyphloroglucinol as active components, has disintegration time within 10s and is not broken easily. The compound phloroglucinol freeze-dried orally-disintegrating tablet (also known as a compound phloroglucinol freeze-dried tablet) comprises main drugs and auxiliary materials, and the auxiliary materials comprise four raw materials. The compound phloroglucinol freeze-dried orally-disintegrating tablet is prepared by a freeze drying technology. The compound phloroglucinol freeze-dried orally-disintegrating tablet has high porosity, just melts in the mouth, has a good taste and no gravel feel, contains a small amount of the auxiliary materials, has small tablet weight and volume, is not broken easily, and can be taken without water and produce effects fast. The compound phloroglucinol freeze-dried orally-disintegrating tablet can disintegrate under the tongue in 10s, can prevent degradation by stomach acid and first-pass hepatic metabolism, can obviously reduce side effects and can reduce stimulation effects on the alimentary canal.

Description

technical field [0001] The invention belongs to the field of pharmaceuticals, in particular to a compound phloroglucinol freeze-dried orally disintegrating tablet and a preparation method thereof. Background technique: [0002] Fucoidan polyphenols are a class of natural products with a unique structure, and their basic structural unit is phloroglucinol. Phloroglucinol, also known as phloroglucinol and garcinol, has been used in France and other European countries for more than 40 years, and in my country for nearly 8 years. Its antispasmodic effect is rapid, the effect is remarkable and the characteristics of no toxic and side effects have been widely recognized by people. The results of a large number of clinical trials have fully affirmed the application value of phloroglucinol in the fields of obstetrics and gynecology, urology, liver-gastroenterology and other fields. [0003] Phloroglucinol / trimethylphloroglucinol belongs to a new type of antispasmodic analgesic drug...

Claims

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Application Information

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IPC IPC(8): A61K31/05A61K9/20A61K47/36A61K47/26A61K47/42A61P29/00A61P1/06
Inventor 宋成刚宋伟国彼得·普劳克斯林文翰陈冀胜吴伟成徐邦潜周洪
Owner SHOUGUANG FUKANG PHARMA
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