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Method for preparing lithospermum extract and application of lithospermum extract

A technology of comfrey extract and comfrey, applied in the field of medicine, can solve the problem of no obvious improvement in the curative effect of ovarian cancer, and achieve the effects of avoiding high-temperature thermal cracking, no chemical solvent residue, and high extraction efficiency

Inactive Publication Date: 2014-01-08
王喜军
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In the past thirty years, the treatment of gynecological cancer has made great progress, but the curative effect of ovarian cancer has not been significantly improved

Method used

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  • Method for preparing lithospermum extract and application of lithospermum extract
  • Method for preparing lithospermum extract and application of lithospermum extract
  • Method for preparing lithospermum extract and application of lithospermum extract

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specific Embodiment approach 1

[0028] Specific embodiment one: the preparation method of a kind of comfrey extract of this embodiment, carries out according to the following steps:

[0029] 1. Preparation of comfrey powder: Dry comfrey at a temperature of 40°C to 50°C to obtain dried comfrey, then crush it into powder, pass through a No. 1 sieve (2000±70μm, 10 mesh), and reserve Under sieve, obtain comfrey powder;

[0030] Second, the use of CO 2 Supercritical extraction technology is used to extract the effective parts of the comfrey powder obtained in step 1, mainly composed of naphthoquinones: put the comfrey powder obtained in step 1 into the extraction kettle, and heat the extraction kettle to 40 ° C ~ 50 ° C , Heat the analytical kettle to 40°C-50°C, heat the storage tank to 30°C-40°C, and then turn on the CO 2 bottle, control CO2 The flow rate is 20L / h~30L / h, and the system is pressurized by a high-pressure pump. When the extraction pressure of the extraction kettle is 15MPa~20MPa, and the analysis...

specific Embodiment approach 2

[0036] Specific embodiment 2: The difference between this embodiment and specific embodiment 1 is that the preparation method of comfrey extract is carried out according to the following steps: 1. Preparation of comfrey powder: placing comfrey in a room with a temperature of 45°C to 50°C drying under the condition to obtain dry comfrey, then pulverize into powder, pass No. 1 sieve, retain under the sieve, obtain comfrey powder; 2. Utilize CO 2 Supercritical extraction technology is used to extract the effective parts of the comfrey powder obtained in step 1, mainly composed of naphthoquinones: put the comfrey powder obtained in step 1 into the extraction kettle, and heat the extraction kettle to 40°C-45°C , Heat the analytical kettle to 40°C-45°C, heat the storage tank to 30°C-40°C, and then turn on the CO 2 bottle, control CO 2 The flow rate is 20L / h~25L / h, and the system is pressurized by a high-pressure pump. When the extraction pressure of the extraction kettle is 15MPa~1...

specific Embodiment approach 3

[0037] Specific embodiment three: the difference between this embodiment and specific embodiment one or two is: the preparation method of comfrey extract is carried out according to the following steps: 1. Preparation of comfrey powder: place comfrey at a temperature of 45°C to 48°C Dry under the condition of ℃ to obtain dry comfrey, then crush it into powder, pass through No. 1 sieve, keep it under the sieve, and obtain comfrey powder; 2. Use CO 2 Supercritical extraction technology extracts the effective parts of the comfrey powder obtained in step 1 mainly composed of naphthoquinones: put the comfrey powder obtained in step 1 into the extraction kettle, and heat the extraction kettle to 40°C-42°C , Heat the analytical kettle to 40°C-42°C, heat the storage tank to 30°C-40°C, and then turn on the CO 2 bottle, control CO 2 The flow rate is 22L / h~25L / h, and the system is pressurized by a high-pressure pump. When the extraction pressure of the extraction kettle is 16MPa~17MPa, ...

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Abstract

The invention discloses a method for preparing a lithospermum extract and application of the lithospermum extract, and relates to the field of medicines. The invention aims at disclosing the method for preparing the lithospermum extract and application of the lithospermum extract to preparing a medicine for treating tumors. The method comprises the following steps: 1, preparing lithospermum powder; 2, extracting effective parts mainly being naphthoquinone compounds of the lithospermum powder obtained in the step 1 by utilizing a CO2 supercritical extraction technology, thus obtaining the wine-colored thick-cream lithospermum extract. The application of the lithospermum extract is the application of the lithospermum extract in preparing the medicine for treating tumors. According to the invention, gynecologic tumors and digestive tract cell lines are emphatically researched and the research result verifies that the effective parts of lithospermum naphthoquinone have exact biological activity for inhibiting growth and inducing apotosis to tumor cell lines, thereby providing a scientific experimental basis for developing hard lithospermum and the effective parts of lithospermum naphthoquinone into a new anticancer drug with a remarkable curative effect and specific targets.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a preparation method and application of comfrey extract. Background technique [0002] Tumor disease has become one of the main enemies that threaten human health and life, and its morbidity and mortality are increasing year by year. Mortality is second only to cardiovascular disease and is the second biggest killer of humans. How to prevent and treat malignant tumors through effective measures has become the primary task of disease prevention and control in my country and the world, and it is also a major issue to be solved urgently by the whole society, especially in the medical field. However, due to the difficulty of early diagnosis of cancer, a considerable number of cancer patients will rely on drug treatment. Therefore, the development and application of anti-tumor drugs is an important field of rapid development of biomedical science. [0003] Cervical cancer is one of the most ...

Claims

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Application Information

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IPC IPC(8): A61K36/30A61P35/00
Inventor 孙晖张爱华王喜军
Owner 王喜军
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