65 results about "Gynecological cancer" patented technology

A multicomponent vaginal cylinder system composed of a tandem capable of housing one or more radiation sources, one or more removable ovoid cartridges, each cartridge capable of housing a radiation source, and a vaginal cylinder structure having corresponding hollow cavities to accommodate the insertions of the tandem and the ovoid cartridges. Radiation shielding may be removably attached to portions of the vaginal cylinder structure to shield tissues from unwanted radiation. A method for using this vaginal cylinder system to treat gynecological cancers is also disclosed.

The present invention provides a method for detecting cancer in a patient. A sample from the patient is provided, and the level of oviduct-specific glycoprotein (OGP) in the sample is determined and compared to a control sample. Increased levels of OGP in the sample as compared to the control indicates that the patient has cancer. In one aspect, the cancer is a gynecological cancer, such as ovarian cancer. Kits for conducting the methods of the invention are also provided.

The present invention relates to an in vitro method for diagnosing epithelial ovarian cancer, cervical cancer, endometriosis, clear cell renal carcinoma and / or predisposition to epithelial ovarian cancer in a subject, the method comprising determining in a sample of the subject gene expression level of at least one gene in the MDS 1 and EVI1 complex (MECOM) locus, and / or copy number of at least one gene in the MECOM locus, wherein the level against at least one expression cutoff value and / or copy number against at least one copy number cutoff value are indicative of the subject having epithelial ovarian cancer, cervical cancer, endometriosis, clear cell renal carcinoma and / or a predisposition to epithelial ovarian cancer cervical cancer, endometriosis, clear cell renal carcinoma and / or determining whether the ovarian cancer in the subject is primary or secondary ovarian cancer and / or a risk of the disease progression after surgery treatment, and / or an effectiveness of post-surgery chemotherapy.

The present invention relates to the use of a compound of formula 3 or a salt thereof for preparing a medicament or a phototherapeutic agent for the treatment of the following diseases, including: acne; AIDS; viral hepatitis; diabetic retinopathy; atypical pneumonia virus infection; coronary Arterial stenosis; carotid artery stenosis; intermittent claudication; Asian (chicken) avian influenza virus infection; cervical dysplasia or various cancers including: blood cancer, cervical cancer, nasopharyngeal cancer, tracheal cancer, laryngeal cancer, bronchial cancer , bronchiolar cancer, bladder cancer, esophagus cancer, stomach cancer, rectal cancer, colon cancer, prostate cancer, hollow organ cancer, bile duct cancer, urinary duct cancer, kidney cancer, uterine cancer, vaginal cancer and other gynecological adnexal cancers. The present invention also relates to methods of treating the above diseases. The present invention further relates to the use of a compound of formula 3 or a salt thereof for the preparation of a photodiagnostic agent for the detection of the above-mentioned diseases and diseases including: atherosclerosis, multiple sclerosis, diabetes, arthritis, rheumatism Arthritis, fungal infection, viral infection, chlamydia infection, bacterial infection, or parasitic infection, HIV infection, hepatitis, herpes simplex, shingles, psoriasis, cardiovascular disease and skin disease. The present invention also relates to methods of detecting the above diseases using photodiagnostic agents. The present invention further relates to a method of cryogenically sterilizing a surgical device or other device, comprising the steps of: providing a compound of formula 3 or a salt thereof on the device; subjecting the device to radiation treatment or sonication. The present invention further relates to a compound of formula 3 or a salt thereof linked or attached to a magnetic element. This compound acts as an MRI enhancer. The present invention also relates to the use of such MRI enhancers for performing MRI scans.

The present invention provides a method for detecting cancer in a patient. A sample from the patient is provided, and the level of oviduct-specific glycoprotein (OGP) in the sample is determined and compared to a control sample. Increased levels of OGP in the sample as compared to the control indicates that the patient has cancer. In one aspect, the cancer is a gynecological cancer, such as ovarian cancer. Kits for conducting the methods of the invention are also provided.

The present invention provides a novel series of cationic, lipid-based, 17α-substituted-estradiol derivatives. The present invention further provides a process for the preparation of a novel series of 17α-substituted-estradiol derivatives. The invention also provides information about highly selective anticancer activities of these molecules in estrogen responsive cell lines. The compound elicits high level of toxicity to gynecological cancer cell lines such as MCF-7, T47D (estrogen receptor positive cell lines), MDA-MB-468 (estrogen receptor knock-out cell line), HeIa (cervical cancer). The present class of cationic lipid-based, estradiol derivatives is likely to find specific use in developing target specifically deliverable anticancer drugs for the treatment of gynecological cancers that are most prevalent in women population irrespective of ethnicity.

The invention belongs to the technical field of medical equipment, and particularly relates to a gynecological tumor sample tissue sampling device which comprises a protective cylinder, an injection cylinder, an injection needle and a sliding rod, and a closing cover capable of being opened and closed is arranged at one end of the protective cylinder; the syringe is arranged in the protective cylinder, the injection needle is connected to the end, close to the sealing cover, of the syringe, and the sliding rod is arranged in the syringe and abuts against the interior of the syringe; a first movable handle which simultaneously penetrates through the side wall of the injection cylinder and the side wall of the protective cylinder and is movable is connected to the sliding rod, and a second movable handle which penetrates through the side wall of the protective cylinder and is movable is connected to the side wall of the injection cylinder; and a limiting device and a fixed handle are arranged on the side wall of the protective cylinder. According to the device, the gun holding posture is kept in the sampling process, the hand easily exerts force, the device is easily held, the injection needle after sampling is located in the sealing cover, the sealing performance is good, and pollution is not likely to be caused.

A lifting device is arranged between a bed board and a bottom frame, the lifting device comprises a bearing plate, a supporting mechanism and a safety lock, the supporting mechanism comprises vertical frames, air springs and connecting rod assemblies which are symmetrically arranged, the two connecting rod assemblies are connected through carrier rollers, the carrier rollers make contact with the bottom face of the bearing plate, and the safety lock is arranged on the supporting plate. One end of each air spring is rotationally connected to the corresponding vertical frame, the other end of each air spring acts on the corresponding connecting rod assembly, the two vertical frames are fixed to the bottom frame, one end of the bearing plate is connected with the synchronous plate, the two sides of the synchronous plate are connected with the wing plates respectively, and the roller sets arranged on the synchronous plate and the wing plates can slide along the vertical frames; the safety locks are symmetrically arranged on the two sides of the bearing plate, each safety lock comprises a ratchet strip and a bidirectional pawl mechanism, the ratchet strips are fixed to the corresponding vertical frames, the bidirectional pawl mechanisms are rotationally arranged on the corresponding wing plates, brake cables used for controlling bidirectional pawls are connected to the brake handles, and the brake handles are connected to the control plate. The transfer bed is stable and comfortable in transfer and safe and reliable in locking.

The invention discloses a gene Panel, a kit and an application for detecting various tumors. The gene panel includes hereditary breast and ovarian cancer syndrome BRCA-related genes, Lynch syndrome-related genes, other genes related to the multiple tumors and key genes of homologous recombination repair pathway. Detection of germline level or combined tumor tissue level can be performed for hereditary breast and ovarian cancer syndrome BRCA-related genes, Lynch syndrome-related genes, other genes related to the various tumors and key genes of homologous recombination repair pathway , and accurately assess the genetic risk of these genes related to gynecological tumors, breast cancer, prostate cancer and digestive tract tumors according to the test results, and guide tumor patients about the application of platinum-based chemotherapy drugs and PARP inhibitors. Comprehensive guidance for precise treatment of various tumors such as gynecological tumors, breast cancer, prostate cancer and digestive tract tumors can be achieved through one test.