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Aidi temperature/pH-sensitive in-situ gel preparation and preparation method thereof

A temperature-sensitive, in-situ gel technology, applied in the direction of pharmaceutical formulations, plant raw materials, medical preparations of non-active ingredients, etc., can solve the problem of low bioavailability, achieve high bioavailability, quality control, avoid painful effects

Inactive Publication Date: 2012-10-17
INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to aim at the disadvantages of serious adverse reactions or low bioavailability of Aidi injection, and to provide a kind of medicine with definite curative effect, stable quality, simple vegetation, easy to use, strong patient compliance, no toxic side effects and adverse effects. A new dosage form of traditional Chinese medicine with high reaction and bioavailability—Aidi temperature / pH sensitive in situ gel and its preparation method

Method used

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  • Aidi temperature/pH-sensitive in-situ gel preparation and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Preparation of Aidi extract

[0021] Take ginseng slices, heat and reflux with 50% ethanol to extract twice, the first time is 3 hours, and the second time is 1.5 hours, combine the extracts, filter, recover ethanol, and prepare the liquid medicine; Three times, 3 hours for the first time, 1.5 hours for the second time, and 1 hour for the third time, combine the decoction, filter, combine the filtrate and ginseng extract, concentrate to 1:1.5 (medicine material: liquid medicine), and add ethanol to make The alcohol content reaches 80%, and it is left standing overnight, filtered, concentrated, and the concentrated solution is vacuum-dried to obtain the product.

Embodiment 2

[0023] Preparation of Aidi temperature / pH sensitive in situ gel preparation

[0024] Prescription: Eddie extract 2.0g, poloxamer 407 14.0g, carbomer 980NF 0.2g, chitosan 0.1g, appropriate amount of sodium hydroxide, distilled water to make up to 100g.

[0025] Preparation method: take the prescribed amount of Aidi extract, put it in an appropriate amount of distilled water, adjust the pH value to about 6.5 to dissolve it, and obtain the Aidi aqueous liquid; take another prescribed amount of poloxamer 407, carbomer 980NF, and chitosan and put it in Aidi In the aqueous solution of the extract, first stir at room temperature to disperse evenly, then refrigerate at 4°C for more than 48 hours to completely dissolve, then make up to 100g with distilled water, mix evenly to obtain a light brown clear solution, fill it, and obtain .

Embodiment 3

[0027] Preparation of Aidi temperature / pH sensitive in situ gel preparation

[0028] Prescription is the same as embodiment 2

[0029] Preparation method: Take the prescribed amount of poloxamer 407, carbomer 980NF, and chitosan in appropriate amount of distilled water, stir at room temperature to disperse evenly, and refrigerate in a refrigerator at 4°C for 24 hours to obtain a transparent glue, then add the prescribed amount of moxa Di extract, stir to make it evenly mixed, adjust the pH value to about 6.5 with appropriate amount of sodium hydroxide, add water to 100g, fill it, and get ready.

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Abstract

The invention belongs to the field of traditional Chinese medicine preparations and relates to an Aidi temperature / pH-sensitive in-situ gel preparation and a preparation method thereof. The Aidi temperature / pH-sensitive in-situ gel preparation is prepared from Aidi extract, in-situ gel matrix acknowledged in the field and other pharmaceutically necessary auxiliary materials by the preparation method. The Aidi temperature / pH-sensitive in-situ gel preparation is liquid which can flow freely at a room temperature. After being taken by a patient, because of a temperature / pH change, the Aidi temperature / pH-sensitive in-situ gel preparation forms semisolid gel. The Aidi temperature / pH-sensitive in-situ gel preparation has the advantages of clear curative effects, stable properties, simple preparation, convenient administration method, strong compliance of patients, no toxic and side effects, no adverse effects and high bioavailability. The Aidi temperature / pH-sensitive in-situ gel preparation has functions of clearing heat, removing toxins, removing stasis and eliminating stagnation, and is suitable for treating a primary liver cancer, a lung cancer, a rectal cancer, a lymph cancer and gynecological cancers.

Description

technical field [0001] The present invention belongs to the field of traditional Chinese medicine, and more specifically relates to a new type of Aidi temperature / pH-sensitive in-situ gel formulations and methods for their preparation. Background technique [0002] The formation mechanism of in situ gel is to use the response of polymer materials to external stimuli, so that the polymer undergoes reversible changes in dispersion state or conformation under physiological conditions, and completes the process of converting from solution to gel. Among them, different polymer materials have a direct impact on the formation of in situ gel. Due to the characteristics of in situ gel formation, it has the advantages of simple preparation, long residence time, and strong tissue affinity with the administration site, and is widely used in the preparation of sustained and controlled release preparations. [0003] Implants are a type of drug delivery system that is implanted through ...

Claims

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Application Information

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IPC IPC(8): A61K36/481A61K9/00A61K47/32A61K47/34A61K47/38A61P35/00A61K35/64
Inventor 陈燕军杨洪军程夏倩顼佳音熊欣
Owner INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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