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Traditional Chinese medicine effervescent tablet for treating cervical carcinoma and preparation method and application thereof

A technology of cervical cancer and effervescent tablets, which is applied in the field of medicine, can solve the problems of unclear material basis of anticancer drugs, complex physiological and pathological characteristics of cervical cancer, and low survival rate, so as to increase the effective component weight and technology Content, improve pharmacological effect and application value, effect of simple extraction method

Pending Publication Date: 2021-03-16
XINJIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although a series of measures such as the trial of anti-HPV virus vaccine, anti-infection treatment, active prevention, and radiotherapy and chemotherapy or hysterectomy for cancerous cervix are being used, due to the complexity of the physiological and pathological characteristics of cervical cancer, this disease still exists. It is an intractable disease in human gynecological tumors that needs to be overcome
Although the traditional chemotherapy drugs for cancer have high curative effect, due to the serious side effects on the human body, the whole course of chemotherapy is unbearable and incomplete. The recurrence rate of the disease is high, and the two-year to five-year survival rate is still low
[0004] Traditional Chinese medicine and Uighur medicine have certain significance in the treatment of cervical cancer. However, due to the traditional treatment methods, the material basis of the anticancer efficacy of pharmaceutical preparations is not clear, the preparation process is simple, and the content of active ingredients is low. The treatment of cancer is still not the first choice. At the same time, because the vaginal suppository in the original prescription is sensitive to temperature, it is easy to liquefy when encountering high temperature, so it needs to be stored in the refrigerator, that is, its stability is poor. and inconvenient transportation

Method used

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  • Traditional Chinese medicine effervescent tablet for treating cervical carcinoma and preparation method and application thereof
  • Traditional Chinese medicine effervescent tablet for treating cervical carcinoma and preparation method and application thereof
  • Traditional Chinese medicine effervescent tablet for treating cervical carcinoma and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The preparation method of the Chinese medicine effervescent tablet for the treatment of cervical cancer comprises the following steps:

[0038] (1) Glycyrrhiza inflate is crushed and sieved to 90 meshes to obtain licorice inflate powder, and the concentration of 8 times the amount of licorice inflate powder is extracted with ethanol, the ethanol extraction concentration is 30%, the extraction temperature is 85 ° C, and each extraction is 0.5 h, ultrasound assisted extraction twice, the extract was filtered and concentrated to dryness to obtain the extract, and then the extract was refined and purified with polyamide and AB-8 macroporous adsorption resin in turn to obtain the standard extract of Glycyrrhiza inflata;

[0039] The preparation method of the above-mentioned pomegranate peel standard extract is as follows: crush the pomegranate peel and sieve to obtain pomegranate peel powder, extract the pomegranate peel powder with 3-12 times the concentration of ethanol, fi...

Embodiment 2

[0047] The preparation method of the Chinese medicine effervescent tablet for the treatment of cervical cancer comprises the following steps:

[0048] (1) Glycyrrhiza inflate is crushed and sieved to 10 meshes to obtain licorice inflate powder, extracted with ethanol at 3 times the concentration of licorice inflate powder, the concentration of ethanol extraction is 95%, the extraction temperature is 6°C, and each extraction is 0.5 h, extract twice, the extract is filtered and concentrated to dryness to obtain the extract, and then the extract is refined and purified with polyamide and AB-8 macroporous adsorption resin in turn to obtain the standard extract of Glycyrrhiza inflata;

[0049] Grind the pomegranate peel and sieve it into 10 meshes to obtain pomegranate peel powder, extract the pomegranate peel powder with ethanol at 3 times the concentration, the ethanol extraction concentration is 85%, the extraction temperature is 50°C, extract 1 hour each time, extract twice, ext...

Embodiment 3

[0057] The preparation method of the Chinese medicine effervescent tablet for the treatment of cervical cancer comprises the following steps:

[0058] (1) Glycyrrhiza inflate is crushed and sieved to 60 meshes to obtain licorice inflate powder, extracted with ethanol at a concentration of 6 times the amount of licorice inflate powder, the ethanol extraction concentration is 60%, the extraction temperature is 75°C, and each extraction is 2h , ultrasonic-assisted extraction twice, the extract was filtered and concentrated to dryness to obtain the extract, and then the extract was refined and purified with polyamide and macroporous resin in turn to obtain the standard extract of Glycyrrhiza inflata;

[0059] Grind the pomegranate peel and sieve it into 60 meshes to obtain pomegranate peel powder, extract the pomegranate peel powder with ethanol at 6 times the concentration, the ethanol extraction concentration is 60%, the extraction temperature is 75°C, extract 2 hours each time, ...

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Abstract

The invention discloses a traditional Chinese medicine effervescent tablet for treating cervical carcinoma. The traditional Chinese medicine effervescent tablet is prepared from glycyrrhiza inflata root standard extract, pomegranate bark standard extract, rhizoma galangae standard extract, galla turcica standard extract and an auxiliary material matrix. According to the preparation method, firstly, the standard extracts of various traditional Chinese medicine materials are obtained by adopting different methods, and then the standard extracts are mixed to prepare the effervescent tablet. According to the preparation method, by taking urgur traditional medicine and modern medical theories as guidance, on the basis of a medical formula taking pomegranate bark, galla turcica and the like as monarch drugs and used for sterilizing, inflammation diminishing, dampness eliminating and astringing, and cervicitis and cervical erosion resisting in the urgur traditional medicine, glycyrrhiza inflate roots and rhizoma galangae are added to optimize the formula composition to prepare the effervescent tablet, and thus, the effective composition component is increased, the effect range is broadened, and the pharmacological effect and the application value are improved. The effervescent tablet disclosed by the invention has good application value in interventional therapy of current high-incidence gynecological tumor-cervical carcinoma.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a traditional Chinese medicine effervescent tablet for treating cervical cancer and its preparation method and application. Background technique [0002] Cervical cancer is a common gynecological malignancy among women all over the world, and it is one of the intractable diseases that threaten women's health and life safety. According to the recent report of WHO, about 500,000 cases of cervical cancer are added every year in the world, and 80% of the cases occur in developing countries. Cervical cancer ranks eighth among the top ten cancers with the incidence rate released by the Cancer Center of my country in 2019, and ranks third among young female cancers, second only to breast cancer and thyroid cancer. Documents at home and abroad show that nearly 99% of women suffering from cervical cancer are related to the infection history of tumor-causing virus HPV. Repeated infection, inflamm...

Claims

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Application Information

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IPC IPC(8): A61K36/9062A61P35/00A61K35/64
CPCA61K9/0007A61K9/2059A61K35/64A61K36/185A61K36/484A61K36/9062A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2236/55A61P35/00A61K2300/00
Inventor 木合布力·阿布力孜
Owner XINJIANG MEDICAL UNIV
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