The invention relates to a supergravity hydrothermal preparation method of spherical inorganic powder grains, which comprises the following steps: preparing a metal salt solution at a concentration of 0.001 to 2mol/L; adding a S<2-> chemical reagent into the obtained solution, and adjusting the pH value of the solution to dissolve the S<2-> chemical reagent, wherein the molar ratio of the metal salt ions to the sulfur ions is 1:1 to 1:5; adding an organic solvent or aqueous high polymer compound into the obtained solution, wherein the volume ratio of the organic solvent or aqueous high polymer compound to the metal salt solution is 1:1 to 1:50; pouring the mixed solution into a high-pressure reaction kettle, sealing the high-pressure reaction kettle, fixing the high-pressure reaction kettle on a fixed bracket in a hearth, and performing a hydrothermal reaction in the presence of supergravity at 50 to 250 DEG C for 0.1 to 5 hours under the action of a relative centrifugal force of 100 to 10,000 grams; and filtering the reaction product, washing the reaction product, and drying the reaction product under vacuum to obtain the needed product. The spherical inorganic powder grains prepared by the invention have the characteristics of high roundness, monodispersion and narrow distribution. The inorganic powder prepared by the method of the invention comprises ZnS, CdS, CuS, PbS, and the like. The inorganic powder grains can be used for manufacturing photonic crystals, rare earth luminescent materials, phononic crystals, solar materials, left-handed materials and the like.