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Medicine composition for treating eczema, seborrheic dermatitis and psoriasis and preparation method thereof

A technology of seborrheic dermatitis and composition, applied in the field of medicine, can solve the problems of low cure rate, long course of treatment, easy recurrence of drug withdrawal, etc.

Inactive Publication Date: 2014-01-22
长春八一医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to solve the defects of the existing drugs for treating dermatitis, eczema and psoriasis that drug withdrawal is easy to repeat, the cure rate is low and the course of treatment is long, and to provide a method for treating eczema, seborrheic dermatitis and psoriasis. Pharmaceutical composition and preparation method thereof

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Weigh 0.04g fluocinonide acetate, 0.1g paeonol and 0.2g ethylparaben, dissolve with 3g ethanol to obtain drug solution;

[0041] Weigh 5g glycerol monostearate, 8g stearic acid, 8g white vaseline, and 8g liquid paraffin, put them in a beaker, heat and melt on a water bath, and keep at 70°C to obtain an oil phase solution; in addition, 12g glycerin, 0.8 Add 55g of sodium lauryl sulfate and 0.2g of azone into 55g of purified water and heat to 70°C to obtain a water phase solution. Slowly add the oil phase solution into the water phase solution and keep stirring in the same direction while adding to obtain a milky white semi-solid like product;

[0042] Stirring and mixing the obtained medicine solution and the milky white semi-solid product to form an ointment, thus obtaining the medicine composition for treating eczema, seborrheic dermatitis and psoriasis.

Embodiment 2

[0044] Take by weighing 0.01g fluocinonide acetate, 0.05g paeonol and 0.3g ethylparaben, dissolve with 5g ethanol to obtain drug solution;

[0045] Weigh 7g of glyceryl monostearate, 10g of stearic acid, 10g of white vaseline, and 10g of liquid paraffin, put them in a beaker, heat and melt on a water bath, and keep at 60°C to obtain an oil phase solution; Sodium lauryl sulfate and 0.5g of azone are added to 60g of purified water and heated to 60°C to obtain a water phase solution. Slowly add the oil phase solution to the water phase solution, and continuously stir in the same direction while adding to obtain a milky white semi-solid product;

[0046] Stirring and mixing the obtained medicine solution and the milky white semi-solid product to form an ointment, thus obtaining the medicine composition for treating eczema, seborrheic dermatitis and psoriasis.

Embodiment 3

[0048] Take by weighing 0.06g fluocinonide acetate, 0.2g paeonol and 0.3g ethylparaben, dissolve with 2g ethanol to obtain drug solution;

[0049] Weigh 5g of glyceryl monostearate, 7g of stearic acid, 7g of white vaseline, and 7g of liquid paraffin, put them in a beaker, heat and melt on a water bath, and keep at 80°C to obtain an oil phase solution; Add 45g of sodium lauryl sulfate and 0.1g of azone into 45g of purified water and heat to 80°C to obtain a water phase solution. Slowly add the oil phase solution into the water phase solution and keep stirring in the same direction while adding to obtain a milky white semi-solid like product;

[0050] Stirring and mixing the obtained medicine solution and the milky white semi-solid product to form an ointment, thus obtaining the medicine composition for treating eczema, seborrheic dermatitis and psoriasis.

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Abstract

The invention provides a medicine composition for treating eczema, seborrheic dermatitis and psoriasis and a preparation method thereof and belongs to the field of medicines. The problems of the existing medicine for treating eczema, seborrheic dermatitis and psoriasis that the disease is easy to relapse after the medicine is not orally taken any more, the curing rate is low and the treatment course is relatively long are solved. The medicine composition is prepared from fluocinonide, paeonol and emulsion matrix. The invention also provides a preparation method of the medicine composition for treating eczema, seborrheic dermatitis and psoriasis. According to the medicine composition, fluocinonide and paeonol are combined to prepare emulsifiable paste, so that the medicine composition has the obvious curative effect in treatment of eczema, seborrheic dermatitis and psoriasis; moreover, the disease is difficultly relapsed and the poor reaction is reduced; the medicine composition is short in treatment course.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a pharmaceutical composition for treating eczema, seborrheic dermatitis and psoriasis and a preparation method thereof. Background technique [0002] Dermatitis and eczema are commonly used to refer to a type of skin inflammation, representing an allergic reaction of the skin to substances such as chemicals, proteins, and bacteria. Eczema has no specific meaning whereas dermatitis has a defined meaning. If dermatitis is used instead of eczema as a diagnostic term, it refers to the combined reaction of the dermis and epidermis, which can be acute, subacute, and chronic, and the three can exist in combination; psoriasis is a chronic inflammatory proliferative skin disease. Complex, there is currently no satisfactory treatment. [0003] At present, the treatment of dermatitis, eczema and psoriasis mostly uses the cream with single fluocinonide acetate or paeonol as the active i...

Claims

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Application Information

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IPC IPC(8): A61K31/58A61K9/06A61P17/00A61P17/06A61K31/12
Inventor 李成姜显肃黄翠汪旭
Owner 长春八一医院
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