Beta-cyclodextrin containing halogen amine antimicrobial agent copolymer as well as preparation method and application of copolymer

A technology of copolymers and antibacterial agents, which is applied in the field of synthesis of haloamine antibacterial agents, can solve the problems of high synthesis reaction temperature, expensive synthetic raw materials, and narrow application range, and achieve the effects of short reaction time, large molecular weight, and low price

Active Publication Date: 2014-02-05
JIANGNAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the above-mentioned halamine antibacterial agents also have some problems in practical application, such as: the synthetic raw materials are expensive; the synthesis reaction temperature is high, the conditions are relatively harsh, and the process is complicated; group, there is still the problem of formaldehyde release during use; the application range is narrow, etc.

Method used

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  • Beta-cyclodextrin containing halogen amine antimicrobial agent copolymer as well as preparation method and application of copolymer
  • Beta-cyclodextrin containing halogen amine antimicrobial agent copolymer as well as preparation method and application of copolymer
  • Beta-cyclodextrin containing halogen amine antimicrobial agent copolymer as well as preparation method and application of copolymer

Examples

Experimental program
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Effect test

Embodiment 1

[0045] The green part of Example 1 is confirmed, if it is not suitable, please modify it.

[0046]Preparation of β-Cyclodextrin-p-Styryl Hydantoin Copolymer

[0047] Weigh maleic anhydride-modified β-cyclodextrin and p-styrylhydantoin with a mass ratio of 1:5, and dissolve it in a mixed solution of 10ml of ethanol and water (the volume ratio of ethanol and water is 4 : 1), under the protection of nitrogen, add 0.5g sodium persulfate and 0.05g sodium bisulfite, and react at 35°C for 7h; after the reaction is completed, the obtained product is distilled under reduced pressure at 60°C to obtain a solid product, and the solid product Repeated washing with distilled water, drying with a vacuum pump, and drying the resulting product at 50°C for 48 hours under vacuum conditions to obtain a precursor of a haloamine antibacterial agent copolymer containing β-cyclodextrin; the precursor was dissolved in a concentration of In 1% sodium hypochlorite solution, let it stand at room tempera...

Embodiment 2

[0049] Preparation of β-Cyclodextrin-Propyl Hydantoin Copolymer

[0050] Weigh maleic anhydride modified β-cyclodextrin and propenyl hydantoin with a mass ratio of 5:1, and dissolve it in a mixed solution of 8ml ethanol and water (the volume ratio of ethanol and water is 1: 1), under the protection of nitrogen, add 0.5g sodium persulfate and 0.05g sodium bisulfite, and react at 70°C for 3h; after the reaction is completed, the obtained product is distilled under reduced pressure at 60°C to obtain a solid product, and the solid product is used Repeatedly washing with acetone and drying with a vacuum pump, the resulting product was dried under vacuum at 50°C for 48 hours to obtain a precursor of a haloamine antibacterial agent copolymer containing β-cyclodextrin; the precursor was dissolved in a concentration of 5% by mass % sodium hypochlorite solution, react at room temperature for 1h, and after the reaction is over, filter and dry (same as above) according to the conventional...

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Abstract

The invention discloses a beta-cyclodextrin containing halogen amine antimicrobial agent copolymer as well as a preparation method and an application of the copolymer. The antimicrobial agent copolymer is a compound shown as a formula (I). The preparation method comprises the steps: dissolving double-bond maleic anhydride modified beta-cyclodextrin and a double-bond halogen amine compound into a mixed solution of ethanol and water, adding a redox initiator, reacting at a temperature of 35-70 DEG C under the protection of nitrogen for 3-10 hours to acquire a beta-cyclodextrin containing halogen amine antimicrobial agent copolymer precursor, and halogenating the precursor to acquire a finished product of the beta-cyclodextrin containing halogen amine antimicrobial agent copolymer. In the application of the beta-cyclodextrin containing halogen amine antimicrobial agent copolymer in preparing antibacterial nano fiber materials, the precursor is mixed with easily spun high polymer materials in proportion in a proper solvent, then nano fiber materials are acquired through electrostatic spinning, and then antibacterial nano fiber materials are acquired after halogenation. The antimicrobial agent copolymer disclosed by the invention has excellent antibacterial performance, the synthetic process is easy and controllable, the reaction time is short, the condition is mild, and the acquired nano fiber materials have good antibacterial performance and high antibacterial efficiency.

Description

technical field [0001] The invention belongs to the technical field of synthesis of haloamine antibacterial agents, and in particular relates to a haloamine antibacterial agent copolymer containing β-cyclodextrin and a preparation method thereof, and the use of the antibacterial agent copolymer in preparing antibacterial nanofiber materials application. Background technique [0002] There are a large number of pathogenic bacteria in the human living environment, and the use of antibacterial agents and articles with antibacterial functions can not only effectively prevent the cross-infection of bacteria between people, people and things, things and things, but also inspire people The disease prevention mode of treatment has changed to preventive measures in advance. [0003] An ideal antibacterial agent should have the following characteristics: cheap and easy-to-obtain raw materials, easy to synthesize, easy to store, long-term effective, not easy to decompose or turn into ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F251/00C08F4/40C08F8/20A01N43/90A01P1/00D01F1/10D01F6/54D01F6/50D01F2/28
Inventor 任学宏李蓉豆建峰姜潜远
Owner JIANGNAN UNIV
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