Technology for recovering acetone in production of cefotaxime sodium

Abstract

The invention discloses a technology for recovering acetone in production of cefotaxime sodium. The technology comprises the following steps: 1) collecting mother liquor into an acetone mother liquor tank, pumping acetone gas in the acetone mother liquor tank through a claw type vacuum pump, and condensing, and collecting the condensed acetone liquor; 2) in the drying step, vacuumizing through the claw type vacuum pump, collecting and condensing the acetone gas produced in the drying process, and collecting the condensed acetone liquor; 3) mixing the acetone liquor collected in the steps 1) and 2) with the remaining mother liquor in the acetone mother liquor tank, to obtain mixed mother liquor; 4) feeding the mixed mother liquor into a rectifying tower for rectification, performing primary condensation and secondary condensation to the extracted gas phase, refluxing obtained condensate into the rectifying tower, and controlling the reflux-extraction ratio to be (3-4):1, performing tertiary condensation on the gas liquor obtained from a primary condensation outlet and a secondary condensation outlet, thus obtaining the acetone. The technology is used for recovering the acetone, the recovery rate is high, and the purity of the recovered acetone can achieve more than 99.5%.

Description

technical field [0001] The invention relates to a recovery process of solvent acetone used in the pharmaceutical industry, in particular to a recovery process of acetone in the production of cefotaxime sodium. Background technique [0002] Cefotaxime sodium is prepared by reacting 7-ACA and AE-active ester under the action of amine intermediate reactants, then adding sodium salt-forming agent for reaction, and finally crystallizing in an organic solvent. The organic solvent can be Ethyl acetate, alcohol solvent or acetone, etc., usually choose acetone. In the production process, the solid-liquid separation equipment used for solid-liquid separation after crystallization and the drying equipment for drying crystals are all produced by vacuum pumps. In the traditional process, the vacuum pumps used are water circulation. vacuum pump. And cefotaxime sodium uses a large amount of acetone in the production, when carrying out suction filtration, drying, most of acetone gas and t...

AI Technical Summary

Problems solved by technology

And cefotaxime sodium uses a large amount of acetone in the production, when carrying out suction filtration, drying, most of acetone gas and trace medicine enter the working water of water-type circulating vacuum pump along with vacuum pipeline, because acetone and water are very easily Miscible, so most of the acetone entering the water-type circulating vacuum pump is dissolved in the circulating water entering the water-type circulating vacuum pump. On the one hand, it is not conducive to the recovery of acetone. On the other hand, if the circulating water is directly discharged into the sewage treatment tank without treatment, A large amount of sewage will be generated, resulting in increased pressure on environmental protection and increased environmental protection costs

In addition, the acetone mother liquor after crystallization is mixed into the acetone mother liquor due to the small amount of dichloromethane remaining in thiaxamic acid, which directly increases the difficulty of recovery. It is difficult to achieve a good separation of dichloromethane and acetone in ordinary recovery, resulting in a purity lower than 98%. % will affect the use, but if it is not recycled, it will not only cause environmental pollution, but also increase production costs

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