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Polysulfone chiral-separation membrane grafted by cyclodextrin through SI-ATRP method, and making method thereof

A chiral separation and cyclodextrin technology, which can be used in semi-permeable membrane separation, organic chemical methods, optical compound separation, etc. It can solve the problems of coating detachment and changing the physical properties of membrane matrix.

Active Publication Date: 2014-02-19
GUANGZHOU CHEM CO LTD CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, blending may change the physical properties of the original membrane substrate; after composite modification, the coating may gradually detach from the membrane substrate as it is used

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1: Preparation of polysulfone chiral separation membrane grafted with cyclodextrin by SI-ATRP method

[0040] (1) Preparation of chloromethyl polysulfone: Dissolve 1 g of polysulfone (S3010 polysulfone from BASF, Germany, with a shear molecular weight of 50,000 Da) in 20 mL of CH 2 Cl 2 Add 0.8g paraformaldehyde (Aladdin Reagent Co., Ltd.), 0.01ml SnCl 4 and 2ml (CH 3 ) 3 SiCl was condensed and stirred at 50°C for 72 hours. After the reaction was completed, it was precipitated in methanol, filtered, dissolved in chloroform, reprecipitated in methanol, freeze-dried overnight to obtain white powder P(SF-CH 2 Cl).

[0041] (2) Dissolve 10 parts of chloromethyl polysulfone and 5 parts of PEG2000 (Aladdin Reagent Co., Ltd.) in 100 parts of DMF to prepare a uniform casting solution. After standing for defoaming, pour the casting solution on the glass plate, adjust the thickness to 100 μm, and scrape evenly. After standing in the air for 30 seconds, immerse the g...

Embodiment 2

[0046] Example 2: Preparation of polysulfone chiral separation membrane grafted with cyclodextrin by SI-ATRP method

[0047] (1) Preparation of chloromethylated polysulfone: Dissolve 3 g of polysulfone in 120 mL of CH 2 Cl 2 In, add 3g paraformaldehyde, 0.04ml SnCl successively 4 and 7ml (CH 3 ) 3 SiCl was condensed and stirred at 50°C for 72 hours. After the reaction was completed, it was precipitated in methanol, filtered, dissolved in chloroform, reprecipitated in methanol, freeze-dried overnight to obtain white powder P(SF-CH 2 Cl).

[0048] (2) Dissolving 30 parts by weight of chloromethyl polysulfone and 10 parts by weight of PVA10000 in 200 parts by weight of DMAc to prepare a uniform casting solution. After standing for defoaming, pour the casting solution on the glass plate, adjust the thickness to 150 μm, and scrape evenly. After standing in the air for 100 seconds, immerse the glass plate in pure water, soak for half an hour, take it out and dry to obtain chlo...

Embodiment 3

[0053] Example 3: Preparation of polysulfone chiral separation membrane grafted with cyclodextrin by SI-ATRP method

[0054] (1) Preparation of chloromethylated polysulfone: Dissolve 5 g of polysulfone in 250 mL of CH 2 Cl 2 In, add 7g paraformaldehyde, 0.2ml SnCl successively 4 and 21ml (CH 3 ) 3 SiCl was condensed and stirred at 50°C for 72 hours. After the reaction was completed, it was precipitated in methanol, filtered, dissolved in chloroform, reprecipitated in methanol, freeze-dried overnight to obtain white powder P(SF-CH 2 Cl).

[0055] (2) Dissolving 50 parts by weight of chloromethyl polysulfone and 20 parts by weight of PVP20000 in 300 parts by weight of NMP to prepare a uniform casting solution. After standing for defoaming, pour the casting solution on the glass plate, adjust the thickness to 120 μm, and scrape evenly. After standing in the air for 60 seconds, immerse the glass plate in pure water, soak for half an hour, take it out and dry it to obtain chl...

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Abstract

The invention belongs to the technical field of polymer membrane materials, and discloses a polysulfone chiral-separation membrane grafted by cyclodextrin through an SI-ATRP method, and a making method and an application thereof. The method includes the following concrete steps: adding a chloromethylpolysulfone membrane, allyl-beta-cyclodextrin and a catalyst into a solvent, sealing, adding a ligand, heating for reacting, washing, and drying to obtain the polysulfone chiral-separation membrane grafted by cyclodextrin through an SI-ATRP method. Chiral recognition sites are introduced into the surface of the membrane and the inner walls of apertures of the membrane through the surface-initiated atom transfer radical polymerization (SI-ATRP) method on the premise that the matrix membrane structure is not destroyed and the use performances of the membrane are not influenced, and the combination between the chiral sites and the membrane matrix are firm; and the grafting density, the length of a graft polymer and the chemical composition of the surface of the membrane can be effectively controlled by adopting a polymerization technology. The Polysulfone chiral-separation membrane grafted by cyclodextrin through the SI-ATRP method can be used in the separation of racemes.

Description

technical field [0001] The invention belongs to the technical field of polymer membrane materials, and in particular relates to a polysulfone chiral separation membrane grafted with cyclodextrin by SI-ATRP method, a preparation method and an application. Background technique [0002] Separation of chiral compounds has received more attention nowadays, mainly due to the growing understanding that different enantiomers of chiral compounds have different metabolic effects in organisms. When a chiral compound enters a living body, its two enantiomers usually exhibit different biological activities. Molecular pharmacology studies have found that chemical drug enantiomers containing chiral factors have significant differences in pharmacological activity, metabolic process and toxicity in the human body. Under normal circumstances, only one enantiomer has pharmacological effects, while the other enantiomer not only has no pharmacological effects, but also produces certain side eff...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D71/68B01D67/00C07B57/00C07D233/64C07D209/20
Inventor 胡继文杨洋苗磊李妃吴艳刘国军林树东刘峰邹海良涂园园吴丹齐键
Owner GUANGZHOU CHEM CO LTD CHINESE ACADEMY OF SCI
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