Unlock instant, AI-driven research and patent intelligence for your innovation.

Idebebone medicinal premix, preparation method thereof and pharmaceutical preparation containing premix

A technology for idebenone and pharmaceutical preparations, which is applied in the field of pharmaceutical preparations, can solve problems such as restricting the clinical application of idebenone, poor fluidity, and severe dust, and achieve the effects of ensuring stability, improving dissolution rate, and promoting release

Active Publication Date: 2014-12-17
HEBEI LONGHAI PHARMA
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are many technical problems in the preparation process of idebenone raw materials: (1) idebenone is almost insoluble in water, and its compatibility with water and dissolution rate need to be improved; (2) idebenone is light in weight , when the crushed particle size is ≥80 mesh, there will be serious electrostatic adsorption, agglomeration, and poor fluidity; (3) raw material loss and serious dust during the crushing process
The above-mentioned technical problems have restricted the clinical application of idebenone

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Idebebone medicinal premix, preparation method thereof and pharmaceutical preparation containing premix
  • Idebebone medicinal premix, preparation method thereof and pharmaceutical preparation containing premix
  • Idebebone medicinal premix, preparation method thereof and pharmaceutical preparation containing premix

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1 Preparation of idebenone medicinal premix

[0017] prescription:

[0018]

[0019] Preparation:

[0020] Take polyethylene glycol D-α-tocopheryl succinate and heat it in a water bath at 50°C to make it into a molten liquid, add idebenone, citric acid, and poloxamer 188 and stir well to make the mixture even, and put it in the refrigerator at -10 ℃ to solidify, pulverize, and place in a vacuum drier at room temperature to dry to constant weight, pulverize and pass through an 80-mesh sieve to obtain idebenone medicinal premix.

Embodiment 2

[0021] Example 2 Preparation of idebenone medicinal premix

[0022] prescription:

[0023]

[0024] Preparation:

[0025] Take polyethylene glycol D-α-tocopheryl succinate and heat it in a water bath at 50°C to make it into a molten liquid, add idebenone, lactic acid, and poloxamer 407 and stir well to make the mixture even, and put it in the refrigerator at -10°C solidified, pulverized, and placed in a vacuum dryer at room temperature to dry to constant weight, pulverized and passed through an 80-mesh sieve to obtain the idebenone medicinal premix.

Embodiment 3

[0026] Example 3 Preparation of idebenone medicinal premix

[0027] prescription:

[0028]

[0029] Preparation:

[0030] Take polyethylene glycol D-α-tocopheryl succinate and heat it in a water bath at 50°C to make it into a molten liquid, add idebenone, fumaric acid, and poloxamer 407 and stir well to make the mixture even, and put it in the refrigerator at - Solidify at 10°C, pulverize, and dry in a vacuum desiccator at room temperature to constant weight, pulverize and pass through an 80-mesh sieve to obtain idebenone medicinal premix.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
solubility (mass)aaaaaaaaaa
melting pointaaaaaaaaaa
Login to View More

Abstract

The invention relates to an idebebone medicinal premix, a preparation method thereof and a pharmaceutical preparation containing the idebebone medicinal premix and belongs to the technical field of pharmaceutical preparations. The medicinal premix contains idebebone, D-alpha-tocopherol polyethylene glycol succinate, an acidifier and a macromolecular nonionic surfactant, wherein the dosage ratio of idebebone to D-alpha-tocopherol polyethylene glycol succinate to the acidifier to the macromolecular nonionic surfactant is 1: (0.5-15): (1-1.5): (2-3). The idebebone medicinal premix disclosed by the invention has the advantages that the problems of light weight, electrostatic adsorption, agglomeration and poor fluidity of idebebone are solved; the problems of raw material loss and dust during crushing are solved; the problem that the preparation has color difference due to the partial melting of raw materials is solved; the restriction that the dissolution degree is improved through reducing granularity is solved, and the required dissolution degree can be achieved without very-fine-granularity crushing or micronizing.

Description

technical field [0001] The invention relates to a medicinal premix, a preparation method thereof, and a pharmaceutical preparation containing the same, in particular to an idebenone medicinal premix, a preparation method thereof, and a pharmaceutical preparation containing the same, belonging to the technical field of pharmaceutical preparations. Background technique [0002] Cerebrovascular disease is a common disease that seriously endangers human health. It has become the first cause of disability and the third cause of death in the world. The incidence of ischemic cerebrovascular disease accounts for about 80% of cerebrovascular diseases. Idebenone is a drug for improving brain metabolism and mental symptoms, which can activate brain mitochondrial respiratory activity, improve cerebral energy metabolism in cerebral ischemia, improve brain glucose utilization rate, increase brain ATP production, and inhibit brain mitochondrial peroxidation. Lipid, which inhibits the membr...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/122A61K47/34A61P9/10A61P9/00A61P25/00
Inventor 程英司翠亚王国振杨亚青
Owner HEBEI LONGHAI PHARMA