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Method and device for enhancing dissolution rate of effective components in coptis chinensis by electron beam irradiation

A technology of electron beam irradiation and active ingredients, applied in organic chemistry, solid solvent extraction, chemical/physical/physicochemical processes using energy, etc., can solve the problems of high dissolution rate, low cost, and high purity of active ingredients, and achieve Improved dissolution rate, simple method, and easy operation

Active Publication Date: 2014-02-26
TECHN PHYSICS INST HEILONGJIANG ACADOF SCI
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Problems solved by technology

[0005] The present invention aims to solve the problems that the existing traditional Chinese medicine extraction methods do not have high dissolution rate of active ingredients, high purity, low cost and suitability for industrialized production, and provides a method and device for improving the dissolution rate of active ingredients in Coptis chinensis by electron beam irradiation

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  • Method and device for enhancing dissolution rate of effective components in coptis chinensis by electron beam irradiation
  • Method and device for enhancing dissolution rate of effective components in coptis chinensis by electron beam irradiation
  • Method and device for enhancing dissolution rate of effective components in coptis chinensis by electron beam irradiation

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specific Embodiment approach 1

[0019] Specific embodiment one: The method for improving the dissolution rate of active ingredients in Coptis chinensis by electron beam irradiation in this embodiment is carried out according to the following steps: irradiate the Coptis chinensis medical material with electron beams, the electron beams are charged particles produced by an electron accelerator, and the electron beams The energy is 1MeV, the radiation dose rate is 0.67kGy / s, and the radiation dose is 2kGy~50kGy.

[0020] In this embodiment, the entire irradiation process is completed at room temperature. The selected Coptidis rhizome is the dried rhizome of Coptis chinensis, a plant of the family Ranunculaceae, and it is pulverized into a powder with a fineness of 850±29 μm.

[0021] The irradiated Coptis chinensis in this embodiment is then tested for the dissolution rate of its active ingredients by the method under the item in the "Chinese Pharmacopoeia", and compared with the traditional Chinese medicine fin...

specific Embodiment approach 2

[0026] Embodiment 2: This embodiment differs from Embodiment 1 in that: the irradiation dose is 10 kGy-40 kGy. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0027] Embodiment 3: This embodiment differs from Embodiment 1 or Embodiment 2 in that: the irradiation dose is 20 kGy-40 kGy. Others are the same as in the first or second embodiment.

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Abstract

The invention relates to a method and a device for enhancing the dissolution rate of effective components in coptis chinensis, particularly to a method and a device for enhancing the dissolution rate of effective components in coptis chinensis by electron beam irradiation. The invention can solve the problem that existing traditional Chinese medicine extraction methods cannot have the characteristics of high effective component dissolution rate, high purity, low cost and suitability for industrial production at the same time. According to the method, electron beams are employed to irradiate the coptis chinensis medicinal material. The device for realizing the method of enhancing the dissolution rate of effective components in coptis chinensis by electron beam irradiation comprises an electron accelerator scanning box, an aluminum plate, a heat conduction instrument, a beam receiving plate, an insulation material body, cooling fans and a beam integrator. By adopting the method provided by the invention, the dissolution rate of berberine in the effective components is increased by 5%-10% compared with a blank sample not subjected to electron beam irradiation, the dissolution rate of palmatine is increased by 4.5%-11% compared with the blank sample not subjected to electron beam irradiation, and electron beam irradiation on the coptis chinensis medicinal material has no significant influence on chemical components. The method and the device can be used for extraction of effective components in coptis chinensis.

Description

technical field [0001] The invention relates to a method and a device for improving the dissolution rate of active ingredients in Coptis chinensis. Background technique [0002] The active ingredients of botanical Chinese medicinal materials are mostly wrapped in the cell wall. The extraction methods currently used are mostly traditional solvent extraction methods, such as decoction method, reflux method, dipping method, percolation method, etc. Most of them use solvents to enter the cells of medicinal materials. Dissolve or disperse the active ingredient and convert it into leachate, that is, the solid-liquid diffusion process of the active ingredient. This process includes the stages of infiltration, penetration, dissolution and diffusion, and replacement. To bring the active ingredient from the cell of the medicinal material into the solution needs to pass through the barrier of the cell wall, so the extraction efficiency is low. [0003] Most of the new technologies for...

Claims

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Application Information

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IPC IPC(8): B01D11/02B01J19/12C07D455/03
Inventor 王强张春静杨仲秋张玉宝梁宏斌斯琴图雅梁爽蒋继成
Owner TECHN PHYSICS INST HEILONGJIANG ACADOF SCI
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