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Method for determining prognosis of renal failure

A technology for prognosis judgment and renal function, applied in disease diagnosis, material inspection products, measuring devices, etc., can solve problems such as changes in blood concentration, vitamin D does not have physiological activity, etc.

Inactive Publication Date: 2014-02-26
KYOWA MEDEX CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Vitamin D itself has almost no physiological activity, and its blood level will fluctuate greatly due to metabolism, transfer to adipose tissue, etc., so it is usually not measured

Method used

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  • Method for determining prognosis of renal failure
  • Method for determining prognosis of renal failure
  • Method for determining prognosis of renal failure

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0090]

[0091] 738 patients with stable chronic kidney disease were selected from the patients with chronic kidney disease registered for the Osaka vitamin D study, and informed consent was obtained for this study. The Ethics Committee of the Osaka University Faculty of Medicine Hospital approved this study. Patient registration was carried out from May 2005 to July 2007, and observations were carried out until July 2010.

[0092]

[0093] Blood samples including whole blood, serum or plasma and urine samples were collected at the time of patient registration, blood samples were centrifuged within 30 minutes, and the obtained serum was stored frozen at -80°C until assayed. Measure creatinine, albumin, calcium and inorganic phosphorus in various samples and calculate eGFR. eGFR was estimated according to the Japanese standard method based on inulin clearance.

[0094] For the measurement of full-length 1-84PTH, a full-length PTH analysis kit manufactured by Scantibodies ...

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Abstract

The present invention relates to a method for determining the prognosis of renal failure, which comprises measuring fibroblast growth factor-23 and 25-hydroxyvitamin D in a biological sample, and a kit for determining the prognosis of renal failure, which comprises a reagent for measuring fibroblast growth factor-23 and a reagent for measuring 25-hydroxyvitamin D. The present invention provides a method for determining the prognosis of renal failure and a kit for determining the prognosis of renal failure, which are useful for deciding on a therapeutic strategy, such as selection of medication, introduction of a stricter diet therapy, and early introduction of dialysis treatment.

Description

technical field [0001] The present invention relates to a method for judging the prognosis of renal failure and a kit for judging the prognosis of renal failure. Background technique [0002] Fibroblast growth factor-23 (hereinafter referred to as FGF-23), a member of the fibroblast growth factor (FGF) family, is a polypeptide composed of 251 amino acids mainly produced by bone tissue, which acts on the kidney to inhibit Phosphorus reabsorption by the renal tubules. Studies in recent years have revealed that diseases such as hypophosphatemic rickets, tumor osteomalacia, and renal failure are related to FGF-23 (see Non-Patent Document 1). Therefore, it is believed that the measurement of FGF-23 in blood is useful for monitoring the pathological state of these diseases, and thus has become a marker that has attracted much attention in recent years (Patent Document 1). [0003] 25-hydroxylated vitamin D (hereinafter referred to as 25(OH)D) is obtained by hydroxylation of vita...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/53
CPCG01N33/74G01N33/82G01N2333/50G01N2800/52G01N2800/347G01N2800/50G01N33/6893G01N33/53G01N33/68
Inventor 滨野高行猪阪善隆松井功
Owner KYOWA MEDEX CO LTD