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Method for recycling edible oil in androstenedione production process through biotransformation

A technology of androstenedione and biotransformation, applied in the direction of organic chemistry, steroids, etc., can solve the problems of environmental pollution, waste of vegetable oil resources, etc., and achieve the effects of protecting the environment, reducing the heating time, and shortening the process.

Active Publication Date: 2014-03-05
SHANGHAI PESTICIDE RES INST +1
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  • Abstract
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Problems solved by technology

If it is discarded, it will not only pollute the environment, but also cause a great waste of vegetable oil resources and the risk of returning to the dining table

Method used

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  • Method for recycling edible oil in androstenedione production process through biotransformation

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Experimental program
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Embodiment 1

[0025] Material source: The biotransformation reaction liquid of androstenedione in the upper section adopts a two-liquid-solid-solid four-phase process, and the obtained biotransformation reaction liquid is a liquid-liquid-solid-solid four-phase system, and the liquid phases are water phase and The oil phase (food grade vegetable oil), the solid phase are the cells and the medium containing the product respectively. The vegetable oil can be corn oil, rapeseed oil, sunflower oil, soybean oil, peanut oil, salad oil, edible blending oil, etc.

[0026] The separation process steps are as follows

[0027] Step 1: Place the liquid-liquid-solid-solid four-phase system in the washing tank and settle naturally. Temperature, 10°C, settling time: about 10 hours.

[0028] Step 2: Open the discharge valve at the bottom of the washing tank, discard the heavy water phase to the three waste collection pool, the liquid-solid-solid three-phase feed liquid left in the washing tank; the liquid...

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Abstract

The invention belongs to the field of chemical engineering and technology. The method comprises the steps of coupling a decanter centrifuge and a scraper evaporator, and separating edible oil from an androstenedione reaction solution produced from biotransformation through extraction, centrifuge, forced evaporation and other technological means, so as to achieve a purpose of recycling the edible oil. The means can shorten heating duration of the edible oil in the separating process, so as to reduce physical change of the edible oil in the separating process, greatly lower raw material cost in the androstenedione production, and reduce waste discharge of the edible oil by 75%. The method can reduce resource waste and protect environment, and is a clean production technology capable of realizing biotransformation of steroids.

Description

technical field [0001] The invention belongs to the technical field of chemical engineering and technology, and specifically relates to a method for recycling and reusing edible-grade oil in the production of pharmaceutical intermediate androstenedione through biotransformation. Background technique [0002] Androstenedione (Androstenedione) is referred to as AD; chemical name: 4-androstenedione-3,17-dione; [CAS number]: 63-05-8, is the production of adrenocortical hormone drugs including diuretic spironolactone (alias : important intermediate of spironolactone, spironolactone sterol). [0003] Using phytosterols that are abundant in nature as raw materials, the method of selectively cutting the side chains of sterols and converting them into AD through microbial fermentation technology is called biotransformation. This process has become a development trend because of its high yield and low pollution. [0004] The transformation of sterols by microorganisms is generally d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J1/00
Inventor 姚再男薛建萍唐璐敏朱健徐玉华李还宝卜桂琴胡月明杨彬
Owner SHANGHAI PESTICIDE RES INST
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