In-vivo controlled degradable bacteriostatic Mg-Ag-Zn-Mn magnesium alloy implant material and preparation method thereof

A technology for implanting materials and organisms, which is applied in the field of high-strength and controllable degradation biomedical magnesium alloys and its preparation, which can solve the problems of non-degradability and achieve the effects of no toxic side effects, pain relief, uniform performance and stability

Active Publication Date: 2014-03-05
SUZHOU ORIGIN MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The invention can not only avoid the problems caused by non-degradable in vivo clinical titanium and stainless steel metal implant materials, but also has good biocompatibility and matching performance of...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] The Mg-Ag-Zn-Mn alloy is prepared by high cleanliness technology, in which the weight percentage of alloy elements is Ag0.2%, Zn5%, Mn0.4%, and the balance is Mg. The purity of the raw material Mg is 99.99%, the purity of Zn is 99.999%, the purity of Mn is 99.9%, and the purity of Ag is greater than or equal to 99.99%.

[0047] The high-clean smelting is protected by inert gas argon, smelted in a water-cooled copper crucible, and the melting temperature is 750°C, and the ingot is poured in a special iron mold.

[0048] The cast ingot was solution treated at 300°C, held for 10 hours and quenched, and then extruded into Φ20mm round bars at an extrusion temperature of 400°C and an extrusion ratio of 20.

[0049] The tensile strength of the Mg-Ag-Zn-Mn alloy obtained under this process is 285MPa, the yield strength is 230MPa, and the elongation is 18%. The results of biological experiments show that the cytotoxicity is 0-1, and it has good biocompatibility. The corrosion r...

Embodiment 2

[0051] The Mg-Ag-Zn-Mn alloy is prepared by high cleanliness technology, in which the weight percentage of alloy elements is Ag0.3%, Zn3.5%, Mn1.0%, and the balance is Mg. The purity of raw material Mg is 99.99%, the purity of Zn is 99.999%, the purity of Mg-10%Mn master alloy is 99.9%, and the purity of Ag is greater than or equal to 99.99%.

[0052] The high-clean smelting is protected by inert gas argon, smelted in a water-cooled copper crucible, and the melting temperature is 750°C, and the ingot is poured in a special iron mold.

[0053] The cast ingot was solution treated at 350°C, held for 5 hours and quenched, and then extruded into a Φ10mm round bar with an extrusion temperature of 350°C and an extrusion ratio of 85.

[0054] The tensile strength of the Mg-Ag-Zn-Mn alloy obtained under this process is 320MPa, the yield strength is 260MPa, and the elongation is 23%. The results of biological experiments show that the cytotoxicity is 0-1, and it has good biocompatibili...

Embodiment 3

[0056] The Mg-Ag-Zn-Mn alloy is prepared by high cleanliness technology, in which the weight percentage of alloy elements is Ag0.3%, Zn2%, Mn0.7%, and the balance is Mg. The purity of the raw material Mg is 99.99%, the purity of Zn is 99.999%, the purity of Mn is 99.9%, and the purity of Ag is greater than or equal to 99.99%.

[0057] The high-clean smelting is protected by inert gas argon, smelted in a water-cooled copper crucible, and the melting temperature is 750°C, and the ingot is poured in a special iron mold.

[0058] The ingot was homogenized at 400°C, held for 2 hours and quenched, and then extruded into a Φ25mm round bar with an extrusion temperature of 150°C and an extrusion ratio of 36.

[0059] The tensile strength of the Mg-Ag-Zn-Mn alloy obtained under this process is 288MPa, the yield strength is 210MPa, and the elongation is 28%. The results of biological experiments show that the cytotoxicity is 0-1, and it has good biocompatibility. The corrosion rate in s...

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Abstract

The invention provides an in-vivo controlled degradable bacteriostatic Mg-Ag-Zn-Mn magnesium alloy implant material and a preparation method thereof. The material has an in-situ bacteriostasis function and comprises the following components in percentage by weight: 0.05-8.0% of Ag, 0.005-6.5% of Zn, 0.1-2.0% of Mn and the balance of Mg. The in-vivo controlled degradable bacteriostatic Mg-Ag-Zn-Mn magnesium alloy implant material not only can be used for solving the problem that the current clinic titanium and stainless steel metal implant materials are non-degradable in vivo, but also can be used for solving the problem that potential toxic elements such as rare earth or an aluminum element and the like exist in the traditional degradable biomedical magnesium alloy technology, has favorable biocompatibility and the mechanics and corrosion degradation matching performance, and also has a remarkable in-situ bacteriostasis effect so that the infection probability of an implanted part is effectively reduced.

Description

technical field [0001] The invention relates to a degradable medical metal material, in particular to a high-strength controllable degradable biomedical magnesium alloy that can be used for implanting instruments and has an in-situ antibacterial function and a preparation method thereof. Background technique [0002] As a biodegradable metal implant material, magnesium alloy has attracted close attention from biomaterial researchers in recent years and has become a research hotspot in this field. The number of patents and scientific research papers on degradable magnesium alloys is increasing year by year. This is mainly because magnesium alloys have the following advantages as biomedical materials: [0003] (1) Magnesium is the fourth most abundant cation in the human body and the second most abundant cation in the cell, and is an indispensable nutrient element for the human body. The total magnesium content in a normal adult body is about 25g, most of which exist in bones...

Claims

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Application Information

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IPC IPC(8): C22C23/04C22C1/02C22F1/06A61L27/04
Inventor 张小农赵常利张绍翔
Owner SUZHOU ORIGIN MEDICAL TECH
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