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CO2 supercritical extraction method for effective components of sonchus arvensis

An effective ingredient and a technology of radicchio, applied in the field of radicchio extraction, can solve the problem that the yield of flavonoids and triterpenoids cannot be guaranteed at the same time, the content of insoluble impurities in supercritical fluid is high, and the active ingredients of medicinal materials are easily destroyed. and other problems, to achieve the effect of good flow and transfer performance, increased extraction capacity, and strong dissolving capacity

Active Publication Date: 2014-03-12
山东世博金都药业有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, water extraction or alcohol extraction is traditionally used to extract the active ingredients in Chinese lettuce. The extraction process has high temperature, which easily destroys the active ingredients in the medicinal materials, consumes a lot of water and ethanol and other solvents, and consumes a lot of energy. and other disadvantages, it is urgent to adopt advanced extraction technology to extract its biologically active components
[0004] The prior art has not yet involved the technology of supercritical extraction of lettuce, and the technical difficulty is that the lettuce contains quercetin, isorhamnetin, koyrin, acacetin, apigenin and teretin. and other flavonoids; it also contains triterpenoids such as oleanolic acid and ursolic acid; its volatile oil contains acids, esters, and alcohols
In the prior art, when the lettuce is extracted by supercritical extraction technology, because the extraction conditions are not easy to grasp, it is impossible to ensure that flavonoids and triterpenoids can obtain higher yields at the same time.
In the prior art, extracting lettuce juice is used as the solute of the supercritical fluid, which easily causes the content of insoluble impurities in the supercritical fluid to be too high, which affects the extraction yield; the residue left by squeezing and filtering lettuce juice still contains a relatively high content flavonoids and triterpenoids, resulting in waste of raw materials

Method used

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  • CO2 supercritical extraction method for effective components of sonchus arvensis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] a) Take 100g of Chinese lettuce medicinal materials and crush them with a crusher, and pass through a 20-mesh sieve;

[0022] b) Soak the broken lettuce in an ethanol-water solution for 2 hours, and the concentration of ethanol in the ethanol-water solution is 30% by volume;

[0023] c) Put the soaked lettuce into the supercritical extraction equipment for CO 2 Supercritical extraction, extraction kettle temperature 60°C, extraction kettle pressure 15Mpa, separation kettle I temperature 65℃, separation kettle I pressure 8Mpa, separation kettle II temperature 35℃, separation kettle II pressure 6Mpa, add 100ml of 30% ethanol as entrainer, The extraction time is 6 hours;

[0024] d) The extracts obtained from the two separation tanks were combined and concentrated at 50° C. under normal pressure for 6 hours to obtain the lettuce extract.

Embodiment 2

[0026] a) Take 100g of Chinese lettuce medicinal materials and crush them with a crusher, and pass through a 10-mesh sieve;

[0027] b) Soak the broken lettuce in an ethanol-water solution for 1 hour, and the concentration of ethanol in the ethanol-water solution is 40% by volume;

[0028] c) Put the soaked lettuce into the supercritical extraction equipment for CO 2 Supercritical extraction, extraction kettle temperature 55°C, extraction kettle pressure 18Mpa, separation kettle I temperature 55°C, separation kettle I pressure 10Mpa, separation kettle II temperature 39°C, separation kettle II pressure 7Mpa, add 100ml of 30% ethanol as entrainer, The extraction time is 6 hours;

[0029] d) Combine the extracts obtained from separation tanks I and II, concentrate at 55° C. under reduced pressure at 0.02 Mpa for 5 hours, and obtain the lettuce extract.

Embodiment 3

[0031] a) Take 100g of Chinese lettuce medicinal materials and crush them with a crusher, and pass through a 10-mesh sieve;

[0032] b) Soak the broken lettuce in an ethanol-water solution for 8 hours, and the concentration of ethanol in the ethanol-water solution is 60% by volume;

[0033] c) Put the soaked lettuce into the supercritical extraction equipment for CO 2 Supercritical extraction, extraction kettle temperature 40°C, extraction kettle pressure 25Mpa, separation kettle I temperature 40°C, separation kettle I pressure 8Mpa, separation kettle II temperature 36°C, separation kettle II pressure 5Mpa, add 100ml of 90% ethanol as entrainer, The extraction time is 1 hour;

[0034] d) Combine the extracts obtained from the separation tanks I and II, and concentrate at 40° C. under normal pressure for 7 hours to obtain the lettuce extract.

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Abstract

The invention relates to a CO2 supercritical extraction method for effective components of sonchus arvensis and belongs to the technical field of sonchus arvensis extraction. The CO2 supercritical extraction method comprises the following steps: firstly, smashing the sonchus arvensis, and sieving the smashed sonchus arvensis with a 10 to 20-mesh sieve; then soaking the sieved sonchus arvensis in an ethanol-water solution; adopting two separation kettles for CO2 supercritical extraction; setting the temperature of an extraction kettle as 35-60 DEG C and the pressure of the extraction kettle as 12-30 Mpa, setting the temperature of the separation kettle I as 40-65 DEG C and the pressure of the separation kettle I as 8-12 Mpa, and setting the temperature of the separation kettle II as 35-40 DEG C and the pressure of the separation kettle II as 5-8 Mpa; adding 10-95% ethanol as an entrainer; setting the extraction time as 2-6 hours; obtaining sonchus arvensis extract after concentrating. Through the adoption of the CO2 supercritical extraction method, the total flavonoid content of the sonchus arvensis extract can be kept at a higher valve and can reach above 3.9 mg / g.

Description

technical field [0001] The CO of the active ingredient in a kind of lettuce 2 The invention discloses a supercritical extraction method, which belongs to the technical field of lettuce extraction. Background technique [0002] Chicory, a plant in the Compositae family, also known as Chicory. Lettuce has the effects of clearing heat and detoxifying, cooling blood and promoting dampness, reducing swelling and draining pus, removing blood stasis and relieving pain, tonifying deficiency and relieving cough. It has a good effect on preventing and treating anemia, maintaining normal physiological activities of the human body, promoting growth and development, and relieving heat and health care. The concentrated ethanol extract of lettuce decoction has inhibitory effect on acute lymphoblastic leukemia, acute and chronic myeloid leukemia. Lettuce is cold in nature and bitter in taste. It has the effects of reducing heat and detoxification, cooling blood, promoting dampness, reduc...

Claims

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Application Information

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IPC IPC(8): A61K36/28
Inventor 闫敬武杜成德郗光建
Owner 山东世博金都药业有限公司
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