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Compound Mongolian medicine preparation for treating coronary heart disease and its preparation process

A technology of coronary heart disease and Mongolian medicine, which is applied in the field of Mongolian medicine compound preparation and its preparation technology for the treatment of coronary heart disease, and can solve problems such as side effects

Active Publication Date: 2017-05-31
INNER MONGOLIA MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Drugs are used to treat coronary heart disease. At present, coronary expansion, lipid-lowering, anticoagulant, calcium blocker, etc. are mostly used. Although they are effective, they all have different degrees of side effects.

Method used

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  • Compound Mongolian medicine preparation for treating coronary heart disease and its preparation process
  • Compound Mongolian medicine preparation for treating coronary heart disease and its preparation process
  • Compound Mongolian medicine preparation for treating coronary heart disease and its preparation process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1. Results of pharmacodynamic studies

[0032] The main pharmacodynamic tests proved that: 1. the compound preparation dropping pills of the present invention can reduce the oxygen consumption of mice and prolong the survival time (P0.05). Such as systolic blood pressure (KPa), diastolic blood pressure (KPa), left ventricular pressure (KPa) and heart rate (beats / min) did not show significant differences (P>0.05). ⑥JnDl dropping pills also had a very obvious antagonistic effect on aconitine-induced arrhythmia (P<0.01). This strongly supports the reason that the original prescription is used for "heart palpitations" in Mongolian medicine.

[0033] Randomly select 50 cases of angina pectoris from typical (diagnosed by national standards) cases, and make a small sample for statistics as follows.

[0034] (1) General data Among the 50 cases, 22 were male and 28 were female; the youngest was 25 years old, the oldest was 80 years old, and most were 40-50 years old; t...

Embodiment 2

[0040] Embodiment 2. Research on the extraction process of compound preparation raw materials

[0041] 1. Extraction of total flavonoids from jujube

[0042] 1. Medicinal materials and materials

[0043] Guangzao is provided by Inner Mongolia Pharmaceutical Company and is identified by the Mongolian Medicine Department of Inner Mongolia Drug Inspection Institute. It belongs to the dry ripe fruit of the Anacardiaceae plant Choerospondias axillaris (Roxb.) Burtt et Hill in the 2000 edition of the Pharmacopoeia of the People's Republic of China. Rutin reference substance: batch number: 00809705, China Institute for the Control of Pharmaceutical and Biological Products; sodium nitrite: analytically pure, batch number: 19990606, Tianjin No. 3 Chemical Reagent Factory; aluminum nitrate: grade III pure, batch number: 660928, Beijing Chemical Plant; hydrogen Sodium oxide: analytically pure, batch number: 20030828, Tianjin Kaitong Chemical Reagent Co., Ltd.; anhydrous ethanol: analyti...

Embodiment 3

[0107] Example 3. Research on molding process

[0108] The conventional dosage form is traditional water pills (5 pills are 1g), the disintegration time limit is unqualified, and it also contains volatile components. It is considered that the bioavailability is low, the stability of the drug is poor, and it is not suitable for the treatment of cardiovascular disease. Therefore, in order to overcome the above drawbacks, it is feasible to consider the dosage form of drop pills. This medicine contains insoluble ingredients and technical powder, and it is planned to use solid dispersion technology to prepare dropping pills.

[0109] 1. Drug prescription

[0110]

[0111] The above prescription medicine is made into 1000 pills.

[0112] 2. Process research

[0113] 1. Inspection of molding process

[0114] The preparation process research involves the investigation of the influence of different substrates and coolants, the ratio of extracts and substrates, the dropping temp...

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PUM

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Abstract

The invention relates to a compound Mongolian medicinal preparation for treating coronary heart disease and a preparation process thereof. The preparation is prepared from the following raw materials in parts by weight: 7-11 parts of fructus choerospondiatis, 4-8 parts of myristica fragrans, 4-8 parts of white sandalwood, 4-8 parts of agilawood, 2-6 parts of safflower, 2-6 parts of amomum tsao-ko, 1-5 parts of cape jasmine, 1 part of ferula, 0.5 parts of calculus bovis factitius and 0.5 parts of borneol. The Mongolian medicinal preparation has the effects of clearing 'khii' heat, circulating qi and blood, and enriching blood, is excellent in curative effect for palpitation, chest distress and irritability, in particular angina and arrhythmia. The invention also relates to a method, which is different from a traditional method, for preparing Mongolian medicinal compound preparation pills.

Description

technical field [0001] The invention relates to the field of medicines for treating coronary heart disease, in particular, to a Mongolian medicine compound preparation for treating coronary heart disease and a preparation process thereof. Background technique [0002] At present, among the three major diseases that threaten human beings, diseases of the cardiovascular system are ranked second. In order to overcome these diseases, people have carried out various researches, and the most important thing is drug research. It has potential significance for conquering ethnic medicine for these difficult diseases. In particular, Mongolian medicine has a good effect on cardiovascular diseases. In recent years, the incidence of coronary heart disease has been on the rise. From the data obtained by the National Disease Detection System in 1990, it can be seen that cardiovascular disease is the leading cause of death in the urban population. Therefore, the research on the treatment...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9064A61P9/10A61K35/413A61K31/045
Inventor 那生桑苏荣扎布佟海英张高娃红梅
Owner INNER MONGOLIA MEDICAL UNIV