Preparation method of dialdehyde carboxymethyl chitosan

A technology of dialdehyde carboxymethyl chitosan and carboxymethyl chitosan, which is applied in the field of preparation of dialdehyde carboxymethyl chitosan, can solve the problem of reducing the molecular weight of carboxymethyl chitosan, which is not conducive to development and utilization, etc. problem, achieve the effect of reducing rigidity and increasing reactivity

Inactive Publication Date: 2014-04-09
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The oxidation mechanism is mainly to oxidize and break the β-(1,4) glycosidic bond on the main chain of carboxymethyl chitosan, without changing its chemical structure, without increasing the reactive functional groups of carboxymethyl chitosan, and Reduce the molecular weight of carboxymethyl chitosan to a great extent, which is not conducive to its further development and utilization

Method used

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  • Preparation method of dialdehyde carboxymethyl chitosan
  • Preparation method of dialdehyde carboxymethyl chitosan

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A kind of preparation method of dialdehyde carboxymethyl chitosan, the steps are by weight:

[0026] (1) Dissolution: Take 4 g of carboxymethyl chitosan, dissolve it in 200 g of water, and stir until dissolved;

[0027] (2) Oxidation reaction: Add 2g of sodium periodate to the solution obtained in step (1), stir until fully dissolved, adjust the pH value to 7.5 with 1mol / L hydrochloric acid solution or 1mol / L sodium hydroxide solution, and the temperature is 40°C, avoid light and stir for 24 hours;

[0028] (3) Stand still: add 20g of ethylene glycol to the solution obtained in step (2), stir evenly, and after standing for 1 hour, add cleaning solution washing solution three times the volume of the mixed solution for 3 times, and let stand for 4 hours;

[0029] (4) Post-treatment: centrifuge the mixed solution obtained in step (3) at a speed of 4000 r / min for 6 min, dialyze, and freeze-dry for 18 hours.

[0030] (5) Drying: Dry the dialdehyde carboxymethyl chitosan ob...

Embodiment 2

[0037] A kind of preparation method of dialdehyde carboxymethyl chitosan, the steps are by weight:

[0038] (1) Dissolution: Take 2g of carboxymethyl chitosan, dissolve it in 100g of water, and stir until dissolved;

[0039] (2) Oxidation reaction: Add 2g of sodium periodate to the solution obtained in step (1), stir until fully dissolved, adjust the pH value to 5 with 1mol / L hydrochloric acid solution or 1mol / L sodium hydroxide solution, temperature 70°C, avoid light and stir for 10 hours;

[0040] (3) Stand still: add 10g of ethylene glycol to the solution obtained in step (2), stir evenly, after standing for 1 hour, add three times the volume of cleaning solution to wash the solution twice, and let stand for 5 hours;

[0041] (4) Post-treatment: centrifuge the mixed solution obtained in step (3) at a speed of 3500 r / min for 8 min, dialyze, and freeze-dry for 12 hours.

[0042] (5) Drying: Dry the dialdehyde carboxymethyl chitosan obtained in step (4) in an oven at 30°C fo...

Embodiment 3

[0047]A kind of preparation method of dialdehyde carboxymethyl chitosan, the steps are by weight:

[0048] (1) Dissolution: Take 8g of carboxymethyl chitosan, dissolve it in 400g of water, and stir until dissolved;

[0049] (2) Oxidation reaction: Add 12g of sodium periodate to the solution obtained in step (1), stir until fully dissolved, adjust the pH value to 9 with 1mol / L hydrochloric acid solution or 1mol / L sodium hydroxide solution, and the temperature is 50°C, avoid light and stir for 24 hours;

[0050] (3) Stand still: Add 40g of ethylene glycol to the solution obtained in step (2), stir evenly, and after standing for 2 hours, add twice the volume of cleaning solution to wash the solution twice, and let stand for 4 hours;

[0051] (4) Post-treatment: centrifuge the mixed solution obtained in step (3) at a speed of 4000 r / min for 6 min, dialyze, and freeze-dry for 20 hours.

[0052] (5) Drying: Dry the dialdehyde carboxymethyl chitosan obtained in step (4) in an oven ...

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Abstract

The invention relates to a preparation method of dialdehyde carboxymethyl chitosan and belongs to the technical field of chitosan preparation. Through dissolution, oxidation reaction, standing, aftertreatment and drying, the dialdehyde carboxymethyl chitosan is prepared. Compared with the existing p-carboxymethyl chitosan modification research technology, the preparation method utilizes periodic acid and its sodium salt as oxidizing agents, under strong selective oxidation effects of the oxidizing agents, carboxymethyl chitosan is oxidation-modified by opening of a pyranoid ring on a molecular chain and then generation of the novel dialdehyde group so that a relatively-high molecular weight oxidation product can be obtained, the oxidation product molecular structure can be changed, reaction activity can be improved and molecular chain rigidity can be reduced. The preparation method has important effects of improving carboxymethyl chitosan polymer crystallinity, molecular chain flexibility and gel performances.

Description

technical field [0001] The invention relates to a preparation method of dialdehyde carboxymethyl chitosan, belonging to the technical field of chitosan preparation. Background technique [0002] Carboxymethyl chitosan is a water-soluble chitosan derivative. Due to the introduction of carboxymethyl groups, it becomes an amphoteric polyelectrolyte containing both amino and carboxyl groups, and carboxymethyl chitosan and chitosan Compared with sugar, it has many characteristics, such as strong antibacterial property and fresh-keeping effect. Therefore, carboxymethyl chitosan is widely used in agriculture, environmental protection, medicine, cosmetics, food processing, fresh-keeping, papermaking and other fields, and it is also one of the chitosan derivatives that have been studied more in recent years. [0003] Studies have shown that many unique physiological activities and functional properties of carboxymethyl chitosan are closely related to the type and quantity of functio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/08
Inventor 龙柱王萍
Owner JIANGNAN UNIV
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