Preparation method and application of novel oral ulcer antibacterial film

Abstract

The invention relates to a preparation method of a novel oral ulcer antibacterial film. The oral ulcer antibacterial film comprises, by weight: 1-20% of polyvinyl alcohol, 1-10% of polyacrylic acid, 0.5-5% of glycerol, 2-10% of water-soluble chitosan, 0.1-5% of bioactive glass, and the balance distilled water. The bioactive glass is evenly dispersed in the glycerol, and the bioactive glass and the glycerol are in a ratio of 1:0.5-1:2. Specifically, the bioactive glass comprises, by weight: 24.5% of CaO, 24.5% of NaO, 45% of SiO2, and 6% of P2O5. During preparation of the oral ulcer antibacterial film provided by the invention, under an aseptic condition, polyacrylic acid, polyvinyl alcohol, a mixed solution of bioactive glass and glycerol, and chitosan are added into distilled water in order, and during adding, the temperature, stirring time, complete dissolution and the pH value of the solution are controlled, thus finally obtaining a film-like material. The oral ulcer antibacterial film provided by the invention has good biocompatibility and degradability, and also has very good bacteriostatic and wound repair functions, thus being applicable to prevention and treatment of oral ulcer.

Description

technical field [0001] The invention relates to a medicine and a dental preparation, in particular to a preparation method and application of a novel oral ulcer antibacterial film. Background technique [0002] Oral ulcers, also known as "oral sores", are superficial ulcers that occur on the oral mucosa. The size can range from rice grains to soybeans, and they are round or oval. The ulcer surface is concave and the surrounding is congested. Ulcers have the characteristics of periodicity, recurrence and self-limitation, and are prone to occur on the lips, cheeks, and tongue margins. The causes of ulcers are local trauma, mental stress, food, drugs, changes in hormone levels, and lack of vitamins or trace elements. Halitosis, red and swollen gums, chronic pharyngitis, constipation, headache, dizziness, nausea, fatigue, irritability, fever, swollen lymph nodes and other systemic symptoms may occur concurrently. Oral ulcers are common and prone to recurrence, which brings gr...

AI Technical Summary

Problems solved by technology

Systemic medication is slow in efficacy, not highly targeted, and long-term use will affect other organs; sprays and gels are difficult to stay on the lesion, and the curative effect is not obvious enough; although patch tablets and capsules can barely stick to the lesion But it is inconvenient to use and easy to fall off when touched by the tongue

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