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Gelatin/carboxymethyl chitosan/POSS (polyhedral oligomeric silsesquioxane) photo-crosslinking hydrogel and preparation method

A technology of carboxymethyl chitosan and cross-linked hydrogel, which is applied in the fields of gelatin/carboxymethyl chitosan/POSS photocross-linked hydrogel and preparation, and achieves inhibition of burst release, improvement of hydrophilicity/hydrophobicity, Fast results in the preparation process

Inactive Publication Date: 2014-04-23
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there are relevant literature reports that gelatin or carboxymethyl chitosan one-component hydrogel is prepared by photocrosslinking, a simple method, but by photocrosslinking There are few reports on the preparation of hydrogels containing both gelatin and chitosan, and this hydrogel containing multiple components can better simulate the natural tissue collagen / polysaccharide composition

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Weigh 10 g of type A gelatin, dissolve it in 100 mL of carbonate buffer solution (CBS) with a pH of 9.6, and stir at 50° C. until completely dissolved. Add 40mL glycidyl methacrylate (GMA), and stir for 3h. The solution was added to 500mL ethanol for precipitation, dialyzed with deionized water for 48 hours, and freeze-dried at -42°C for 48 hours to obtain a modified gelatin (Gel-GMA) with a double bond modification degree of 23%;

[0022] Weigh 1 g of carboxymethyl chitosan with a number average molecular weight of 9000 and a degree of deacetylation of 95%, dissolve it in 100 mL of deionized water, stir at 50 °C until completely dissolved, then add 5 mL of triethylamine, 15 mL of GMA and 5 g of Tetrabutylammonium bromide was reacted at room temperature for 72h. Pour the above solution into 500mL ethanol for precipitation, dialyze with deionized water for 48 hours, and freeze-dry at -42°C for 48 hours to obtain a modified carboxymethyl chitosan (CS-GMA) with a double b...

Embodiment 2

[0025] Weigh 10 g of type A gelatin, dissolve it in 100 mL of CBS buffer solution with a pH of 9.6, and stir at 50° C. until completely dissolved. 120 mL of GMA was added and the reaction was stirred for 3 h. The solution was added to 500 mL of ethanol for precipitation, dialyzed with deionized water for 48 hours, and freeze-dried at -42°C for 48 hours to obtain a modified gelatin (Gel-GMA) with a double bond modification degree of 43%;

[0026] Weigh 1 g of carboxymethyl chitosan with a number average molecular weight of 9000 and a degree of deacetylation of 95%, dissolve it in 100 mL of water, stir at 50 °C until completely dissolved, then add 5 mL of triethylamine, 15 mL of GMA and 5 g of tetrabutyl Ammonium bromide was reacted at room temperature for 72 hours, the above solution was poured into 500mL ethanol for precipitation, dialyzed in deionized water for 48 hours, and freeze-dried at -42°C for 48 hours to obtain a modified carboxymethyl shell with a double bond modific...

Embodiment 3

[0029] Weigh 10 g of type A gelatin, dissolve it in 100 mL of CBS buffer solution with a pH of 9.6, and stir at 50° C. until completely dissolved. 120 mL of GMA was added and the reaction was stirred for 3 h. The solution was added to 500 mL of ethanol for precipitation, dialyzed with deionized water for 48 hours, and freeze-dried at -42°C for 48 hours to obtain a modified gelatin (Gel-GMA) with a double bond modification degree of 43%;

[0030] Weigh 1 g of carboxymethyl chitosan with a number average molecular weight of 9000 and a degree of deacetylation of 95%, dissolve it in 100 mL of water, stir at 50 °C until completely dissolved, then add 5 mL of triethylamine, 15 mL of GMA and 5 g of tetrabutyl Ammonium bromide was reacted at room temperature for 72 hours, the above solution was poured into 500mL ethanol for precipitation, dialyzed in deionized water for 48 hours, and freeze-dried at -42°C for 48 hours to obtain a modified carboxymethyl shell with a double bond modific...

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Abstract

The invention discloses gelatin / carboxymethyl chitosan / POSS (polyhedral oligomeric silsesquioxane) photo-crosslinking hydrogel and a preparation method. Main components of the hydrogel consist of modified gelatin, modified carboxymethyl chitosan and octavinyl oligomerization silsesquioxane. The preparation method comprises the following steps: executing the double bond modification for the gelatin and the carboxymethyl chitosan by utilizing methacrylic acid glycidyl ester; mixing the modified gelatin, the modified carboxymethyl chitosan, the octavinyl oligomerization silsesquioxane, the cross-linking PEGDMA and the photo initiator 12959 to a solution, and photo-crosslinking the mixture to prepare the hydrogel. The gelatin / carboxymethyl chitosan / POSS photo-crosslinking hydrogel has the advantages that the preparation process is fast and simple, and the prepared hydrogel has biological compatibility; meanwhile, octavinyl oligomerization silsesquioxan is introduced into the system, so that the mechanical property of the gel can be remarkably improved, the biological and mechanical requirements of the repaired tissue can be simultaneously met, and the hydrogel has good application prospect on the aspect for restoring bones and basibranchial bones.

Description

Technical field [0001] The present invention involves a gelatin / carboxymethyl shell / POSS optical hydrogel and preparation method, which belongs to the technology field of biolite material. Background technique [0002] The structure of the hydrogel is similar to the extracellular matrix (ECM), which can provide appropriate conditions for tissue cells and tissue growth, and can achieve tissue repair through in situ injection and other methods. Therefore, it is a type of tissue repair and regeneration.Very important material.In the different methods of preparing hydrogel, the optical Federation is widely used due to the advantages of aggregate space and time, rapid reaction at room temperature or physiological temperature, less calories and formation of in situ.Organization can make implantation organizations in good contact with the surrounding tissue environment.Specifies the hydrogels in the polyoxitetic ethylene (PEO) solution through optical cross -linked. After two weeks, the...

Claims

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Application Information

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IPC IPC(8): C08J3/28C08J3/24C08J3/075C08L89/00C08L5/08C08L83/07C08H1/00C08B37/08
Inventor 袁晓燕杨晓玲
Owner TIANJIN UNIV
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