Gelatin/carboxymethyl chitosan/POSS (polyhedral oligomeric silsesquioxane) photo-crosslinking hydrogel and preparation method
A technology of carboxymethyl chitosan and cross-linked hydrogel, which is applied in the fields of gelatin/carboxymethyl chitosan/POSS photocross-linked hydrogel and preparation, and achieves inhibition of burst release, improvement of hydrophilicity/hydrophobicity, Fast results in the preparation process
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Embodiment 1
[0021] Weigh 10 g of type A gelatin, dissolve it in 100 mL of carbonate buffer solution (CBS) with a pH of 9.6, and stir at 50° C. until completely dissolved. Add 40mL glycidyl methacrylate (GMA), and stir for 3h. The solution was added to 500mL ethanol for precipitation, dialyzed with deionized water for 48 hours, and freeze-dried at -42°C for 48 hours to obtain a modified gelatin (Gel-GMA) with a double bond modification degree of 23%;
[0022] Weigh 1 g of carboxymethyl chitosan with a number average molecular weight of 9000 and a degree of deacetylation of 95%, dissolve it in 100 mL of deionized water, stir at 50 °C until completely dissolved, then add 5 mL of triethylamine, 15 mL of GMA and 5 g of Tetrabutylammonium bromide was reacted at room temperature for 72h. Pour the above solution into 500mL ethanol for precipitation, dialyze with deionized water for 48 hours, and freeze-dry at -42°C for 48 hours to obtain a modified carboxymethyl chitosan (CS-GMA) with a double b...
Embodiment 2
[0025] Weigh 10 g of type A gelatin, dissolve it in 100 mL of CBS buffer solution with a pH of 9.6, and stir at 50° C. until completely dissolved. 120 mL of GMA was added and the reaction was stirred for 3 h. The solution was added to 500 mL of ethanol for precipitation, dialyzed with deionized water for 48 hours, and freeze-dried at -42°C for 48 hours to obtain a modified gelatin (Gel-GMA) with a double bond modification degree of 43%;
[0026] Weigh 1 g of carboxymethyl chitosan with a number average molecular weight of 9000 and a degree of deacetylation of 95%, dissolve it in 100 mL of water, stir at 50 °C until completely dissolved, then add 5 mL of triethylamine, 15 mL of GMA and 5 g of tetrabutyl Ammonium bromide was reacted at room temperature for 72 hours, the above solution was poured into 500mL ethanol for precipitation, dialyzed in deionized water for 48 hours, and freeze-dried at -42°C for 48 hours to obtain a modified carboxymethyl shell with a double bond modific...
Embodiment 3
[0029] Weigh 10 g of type A gelatin, dissolve it in 100 mL of CBS buffer solution with a pH of 9.6, and stir at 50° C. until completely dissolved. 120 mL of GMA was added and the reaction was stirred for 3 h. The solution was added to 500 mL of ethanol for precipitation, dialyzed with deionized water for 48 hours, and freeze-dried at -42°C for 48 hours to obtain a modified gelatin (Gel-GMA) with a double bond modification degree of 43%;
[0030] Weigh 1 g of carboxymethyl chitosan with a number average molecular weight of 9000 and a degree of deacetylation of 95%, dissolve it in 100 mL of water, stir at 50 °C until completely dissolved, then add 5 mL of triethylamine, 15 mL of GMA and 5 g of tetrabutyl Ammonium bromide was reacted at room temperature for 72 hours, the above solution was poured into 500mL ethanol for precipitation, dialyzed in deionized water for 48 hours, and freeze-dried at -42°C for 48 hours to obtain a modified carboxymethyl shell with a double bond modific...
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