Application of extracting solution of natural multi-form arsenic

Abstract

The invention provides application of an extracting solution of natural multi-form arsenic. The extracting solution of natural multi-form arsenic is applicable to preparation of medicines for resisting tumor stem cell, resisting hepatitis B and resisting human immunodeficiency virus; the extracting solution of natural multi-form arsenic added with pharmaceutically acceptable auxiliaries can be prepared to be soft capsules, hard capsules, pills, tablets, granules, injections or powder injections, oral liquid, microcapsules, dropping pills, aerosol and suppository preparations, and can be taken by oral, injection or rectum. The extracting solution of natural multi-form arsenic can inhibit hepatitis B and resist human immunodeficiency virus and other viruses, and expands the applicable scope of natural arsenicals in development and utilization.

Description

【Technical field】 [0001] The invention relates to the application of an extract solution of natural arsenic in various forms. 【Background technique】 [0002] Tumor is the most common malignant tumor that threatens human health. Despite the continuous development of radiotherapy, chemotherapy and surgery, the mortality rate is still high. For example, as a common type of non-small cell lung cancer (NSCLC), the overall 5-year survival rate is still less than 15%. Based on the theory of cancer stem cells (CSC), it is believed that cancer stem cells with self-renewal and infinite proliferation capabilities are the "root" of cancer occurrence and recurrence (public document: Yang Ming. Nano-realgar on lung cancer and liver cancer cells and The apoptosis-inducing effect of tumor stem cells. [D]. Doctoral dissertation of Lanzhou University: Lanzhou. 2010, P10-15). For this reason, a drug screening strategy aimed at inhibiting cancer stem cells will be a new way of cancer treatmen...

AI Technical Summary

Problems solved by technology

However, the preparation technology reported in modern times includes methods such as water flying + vinegar production, nano- and micronization, and the result is only a suspension, which cannot meet the requirements of current pharmaceutical preparations. A acidophilic Thiobacillus for metallurgy, extracting realgar to produce a mixed extract containing arsenic acid (III, V), methyl MMA (V) and a large amount of auxiliary elements (iron and iron compounds) (public documents are as follows: Li Hongyu, Zhang Jinghong, Zhi Dejuan. Heavy metal removal method in mineral medicine. Chinese patent [P]: 200610200067.5, 2006-1-02.), although these methods can obtain a mixed solution containing some forms of arsenic, but due to the mixed Other ingredients, whose exact active ingredients cannot be determined at present, cannot form complexes with other drugs or excipients, and its in vitro inhibitory effect on tumor cells such as lung cancer and liver cancer is significantly lower than that of As 2 o 3 , and more importantly, it has not yet been seen that it can inhibit tumor stem cells, hepatitis B and HIV at the same time

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