Application of gingko extract nanometer liposome in acne removing and dermatosis treatment

A technology of Ginkgo biloba extract and nanoliposome is applied in the fields of biomedicine and therapeutic cosmetics, can solve the problems such as no reports on the application of ginkgo extract nanoliposome, and achieves wide range of effects, significant therapeutic effect, and no use. Effects of side effects

Inactive Publication Date: 2014-04-30
王青
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There is no report on the application of gin

Method used

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  • Application of gingko extract nanometer liposome in acne removing and dermatosis treatment
  • Application of gingko extract nanometer liposome in acne removing and dermatosis treatment
  • Application of gingko extract nanometer liposome in acne removing and dermatosis treatment

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0019] Example 1:

[0020] Peel the ginkgo and place it in a tissue masher to crush. Accurately weigh a certain amount of crushed ginkgo, add 80% ethanol with a material-to-liquid ratio of 1:10 (W / V), stir and extract twice at a water bath temperature of 60°C, with each extraction time of 4 hours. After the extraction, centrifuge (5000 rpm, 15 minutes), and take the supernatant. Concentrate the supernatant with a vacuum rotary evaporator under the conditions of a temperature of 55°C, a pressure of 0.008-0.009MPa, concentration under reduced pressure, and vacuum drying at 60°C to obtain a ginkgo extract extract. The properties are: light yellow extract, soluble Alcohol, insoluble in water.

[0021] Phospholipid absolute ethanol solution, filter; add the above-mentioned ginkgo extract extract and vitamin E, shake evenly, place in a round bottom flask, rotate and evaporate in a water bath at 30℃, and form a film under reduced pressure to make the film uniformly formed on the bottle ...

Example Embodiment

[0023] Example 2:

[0024] Peel the ginkgo and place it in a tissue masher to crush. Accurately weigh a certain amount of crushed ginkgo, add distilled water with a material-to-liquid ratio of 1:10 (W / V), stir and extract twice at a water bath temperature of 60°C, with each extraction time of 4 hours. After the extraction, centrifuge (5000 rpm, 15 minutes), and take the supernatant. The supernatant was concentrated and dried in vacuum at 60°C to obtain the Ginkgo biloba extract extract. The properties were: light yellow extract, soluble in alcohol but insoluble in water.

[0025] The ginkgo extract nanoliposome suspension was prepared according to the preparation process of the ginkgo extract nanoliposome suspension.

[0026] Preparation of gel: Sprinkle 10 g of Carbopol on the surface of 500 ml of distilled water and swell overnight. Weigh 60 g of glycerin and 120 ml of propylene glycol, respectively add them to the swollen carbopol, and quickly grind uniformly to obtain a transp...

Example Embodiment

[0027] Example 3:

[0028] Peel the ginkgo and place it in a tissue masher to crush. Accurately weigh a certain amount of crushed ginkgo, add 80% petroleum ether with a material-to-liquid ratio of 1:10 (W / V), stir and extract twice at a water bath temperature of 60°C, with each extraction time of 4 hours. After the extraction, centrifuge (5000 rpm, 15 minutes), and take the supernatant. Concentrate the supernatant with a vacuum rotary evaporator under the conditions of a temperature of 55°C, a pressure of 0.008-0.009MPa, concentration under reduced pressure, and vacuum drying at 60°C to obtain a ginkgo extract extract. The properties are: light yellow extract, soluble Alcohol, insoluble in water.

[0029] The ginkgo extract nanoliposome suspension was prepared according to the preparation process of the ginkgo extract nanoliposome suspension.

[0030] Preparation of ointment: take 5ml of the ginkgo extract nanoliposome suspension, dissolve it in 100ml of 95% ethanol solution, add ...

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PUM

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Abstract

The present invention relates to a use of gingko extract nanometer liposome in preparation of external application preparations for acne removing and dermatosis treatment. According to the present invention, the gingko extract can be obtained from extracts of leaf, fruit, exopleura, rhizome and other parts of gingko through a chemical separation method; the gingko extract nanometer liposome is prepared by using a film ultrasound-high pressure homogenization method; the dermatosis is infectious, inflammatory and allergic skin diseases; the drug, the cosmetic or the disinfectant external application preparation containing the gingko extract nanometer liposome and provided for acne removing and dermatosis treatment contains 0.001-80% of the gingko extract nanometer liposome; results of pharmacology studies show that the gingko extract nanometer liposome provides significant anti-common skin pathogen infection effects, anti-inflammatory effects and anti-allergic effects, and the effect of the gingko extract nanometer liposome is significantly superior to the effect of the gingko extract external application preparation control group; and results of clinical trials on infectious or allergic skin disease patients show that the gingko extract nanometer liposome provides significant treatment effects for a variety of skin diseases, wherein the effective rate is 100%, and characteristics of safe use and no side effect are provided.

Description

technical field [0001] The invention belongs to the technical field of biomedicine and therapeutic cosmetics, and specifically relates to the application of ginkgo extract nano liposomes in treating skin diseases and removing acne. Background technique [0002] Most skin diseases have a long duration and are prone to recurrent attacks, which bring pain to patients and seriously affect their physical and mental health. Dermatitis can be divided into infectious and non-infectious. Infectious skin diseases can be caused by bacteria, viruses, fungi and pathogens, such as acne, impetigo, folliculitis, herpes, tinea manuum, tinea corporis, acariasis, scabies, etc.; acne can be caused by Propionibacterium acnes and Staphylococcus aureus Caused by infection. Non-infectious skin diseases are mostly allergic or allergic skin diseases, such as neurodermatitis, eczema, urticaria, sweat rash, pruritus, etc. At present, most infectious skin diseases are treated with antibacterial drugs...

Claims

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Application Information

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IPC IPC(8): A61K36/16A61K8/97A61K8/14A61K9/127A61P17/00A61P17/10A61P37/08A61P31/04A61P31/10A61P33/00A61P31/12A61P17/12A61P17/04A61P17/06A61Q19/00
Inventor 雷红王青
Owner 王青
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