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Application of gingko extract nanometer liposome in acne removing and dermatosis treatment

A technology of Ginkgo biloba extract and nanoliposome is applied in the fields of biomedicine and therapeutic cosmetics, can solve the problems such as no reports on the application of ginkgo extract nanoliposome, and achieves wide range of effects, significant therapeutic effect, and no use. Effects of side effects

Inactive Publication Date: 2014-04-30
王青
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There is no report on the application of ginkgo extract nanoliposomes in acne and skin diseases

Method used

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  • Application of gingko extract nanometer liposome in acne removing and dermatosis treatment
  • Application of gingko extract nanometer liposome in acne removing and dermatosis treatment
  • Application of gingko extract nanometer liposome in acne removing and dermatosis treatment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Peel the ginkgo nuts and crush them in a tissue grinder. Accurately weigh a certain amount of crushed ginkgo fruit, add 80% ethanol with a solid-to-liquid ratio of 1:10 (W / V), and stir and extract twice at a water bath temperature of 60°C, each extraction time is 4 hours. After the leaching, centrifuge (5000 rpm, 15 minutes), and take the supernatant. Concentrate the supernatant with a vacuum rotary evaporator under the conditions of temperature 55°C, pressure 0.008-0.009MPa, concentrate under reduced pressure, and vacuum-dry at 60°C to obtain Ginkgo biloba extract. The properties are: light yellow extract, soluble in Alcohol, insoluble in water.

[0021] Phospholipid anhydrous ethanol solution, filter; add the above-mentioned ginkgo extract extract, vitamin E, shake evenly, put in a round bottom flask, 30 ℃ water bath constant temperature rotary evaporation, reduce pressure to form a film, so that the film material is uniformly formed on the bottle wall Add PBS buffe...

Embodiment 2

[0024] Peel the ginkgo nuts and crush them in a tissue grinder. Accurately weigh a certain amount of crushed ginkgo fruit, add distilled water with a solid-to-liquid ratio of 1:10 (W / V), and stir and extract twice at a water bath temperature of 60°C, each extraction time is 4 hours. After the leaching, centrifuge (5000 rpm, 15 minutes), and take the supernatant. Concentrate the supernatant, and dry it under vacuum at 60°C to obtain the ginkgo extract. The properties are: light yellow extract, soluble in alcohol, insoluble in water.

[0025] Ginkgo extract nanoliposome suspension was prepared according to the preparation process of Ginkgo extract nanoliposome suspension in Example 1.

[0026] Preparation of the gel: Sprinkle 10 g of Carbopol on the surface of 500 ml of distilled water, and swell overnight. Weigh 60 g of glycerin and 120 ml of propylene glycol, respectively add them to the swollen Carbopol, and grind them evenly to obtain a transparent gel matrix. Take 40ml o...

Embodiment 3

[0028] Peel the ginkgo nuts and crush them in a tissue grinder. Accurately weigh a certain amount of crushed ginkgo fruit, add 80% petroleum ether with a solid-liquid ratio of 1:10 (W / V), and stir and extract twice at a water bath temperature of 60°C, each extraction time is 4 hours. After the leaching, centrifuge (5000 rpm, 15 minutes), and take the supernatant. Concentrate the supernatant with a vacuum rotary evaporator under the conditions of temperature 55°C, pressure 0.008-0.009MPa, concentrate under reduced pressure, and vacuum-dry at 60°C to obtain Ginkgo biloba extract. The properties are: light yellow extract, soluble in Alcohol, insoluble in water.

[0029] Ginkgo extract nanoliposome suspension was prepared according to the preparation process of Ginkgo extract nanoliposome suspension in Example 1.

[0030] Preparation of ointment: Take 5ml of the above-mentioned ginkgo extract nanoliposome suspension, dissolve it in 100ml of 95% ethanol solution, add 50ml of trie...

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Abstract

The present invention relates to a use of gingko extract nanometer liposome in preparation of external application preparations for acne removing and dermatosis treatment. According to the present invention, the gingko extract can be obtained from extracts of leaf, fruit, exopleura, rhizome and other parts of gingko through a chemical separation method; the gingko extract nanometer liposome is prepared by using a film ultrasound-high pressure homogenization method; the dermatosis is infectious, inflammatory and allergic skin diseases; the drug, the cosmetic or the disinfectant external application preparation containing the gingko extract nanometer liposome and provided for acne removing and dermatosis treatment contains 0.001-80% of the gingko extract nanometer liposome; results of pharmacology studies show that the gingko extract nanometer liposome provides significant anti-common skin pathogen infection effects, anti-inflammatory effects and anti-allergic effects, and the effect of the gingko extract nanometer liposome is significantly superior to the effect of the gingko extract external application preparation control group; and results of clinical trials on infectious or allergic skin disease patients show that the gingko extract nanometer liposome provides significant treatment effects for a variety of skin diseases, wherein the effective rate is 100%, and characteristics of safe use and no side effect are provided.

Description

technical field [0001] The invention belongs to the technical field of biomedicine and therapeutic cosmetics, and specifically relates to the application of ginkgo extract nano liposomes in treating skin diseases and removing acne. Background technique [0002] Most skin diseases have a long duration and are prone to recurrent attacks, which bring pain to patients and seriously affect their physical and mental health. Dermatitis can be divided into infectious and non-infectious. Infectious skin diseases can be caused by bacteria, viruses, fungi and pathogens, such as acne, impetigo, folliculitis, herpes, tinea manuum, tinea corporis, acariasis, scabies, etc.; acne can be caused by Propionibacterium acnes and Staphylococcus aureus Caused by infection. Non-infectious skin diseases are mostly allergic or allergic skin diseases, such as neurodermatitis, eczema, urticaria, sweat rash, pruritus, etc. At present, most infectious skin diseases are treated with antibacterial drugs...

Claims

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Application Information

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IPC IPC(8): A61K36/16A61K8/97A61K8/14A61K9/127A61P17/00A61P17/10A61P37/08A61P31/04A61P31/10A61P33/00A61P31/12A61P17/12A61P17/04A61P17/06A61Q19/00
Inventor 雷红王青
Owner 王青
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