Porcine pseudorabies mutant strain ge and gi gene deletion virus strain and its application

A technique for porcine pseudorabies and gene deletion, which can be used in antiviral agents, viruses/phages, biochemical equipment and methods, etc.
CN103756977BActive Publication Date: 2016-01-06JIANGSU NANNONG HI TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
JIANGSU NANNONG HI TECH
Publication Date
2016-01-06

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Abstract

The present invention involves the field of pseudo-rabies virus technology. It specially involves a pseudo-pseudo-rabies disease variable and GI gene lack of virus strain PRV-ZJ011g. The preservation number is CGMCC?No.7957.Its application in the preparation of vaccines.Will 106.0?The TCID50 reorganization virus inocus the New Zealand big white rabbit, which did not cause itching and other clinical symptoms.Made into an oily vaccine, 4 weeks of GB after the piglets are immunized?ELISA antibody is positive, but GE antibody is negative, and immune protection efficiency is 100%. After the sow immunization, its offspring can obtain immune protection, which is 100%of PRV mutant poison and traditional toxic immune protection efficiency;Can be used for vaccine preparation.
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Description

technical field

[0001] The invention relates to the technical field of porcine pseudorabies virus, in particular to a porcine pseudorabies variant gE and gI gene deletion virus strain, and also relates to the application of the virus strain. Background technique

[0002] Porcine pseudorabies virus ( Pseudorabies virus , PRV) is a member of the herpesviridae herpesvirus A subfamily, which can cause central nervous system disorders in newborn piglets, respiratory symptoms in growing pigs, and can cause abortion, stillbirth and weak piglets in pregnant sows. The United States and some European countries have declared the eradication and eradication of the disease. The gene-deficient attenuated vaccine is widely used in my country to effectively control and gradually purify it.

[0003] Huazhong Agricultural University applied for a publication number CN1940063A in 2005, titled "A Pseudorabies E - / gI - Gene Deletion Strain, Inactivated Vaccine Containing the Strain, and App...

Claims

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