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Method for preparing curcumin lipid nano-particle suspension or nano-particles

A curcumin lipid and nanoparticle technology, which is applied in the direction of making medicines into special physical or taking form devices, liquid delivery, emulsion delivery, etc. operation and other problems, to achieve the effect of high uniformity, high drug encapsulation rate, and prevention of precipitation

Active Publication Date: 2014-05-07
浙江佳泰科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation process of this method is complicated, and the system needs to be made into a colloidal substance first, which is not conducive to operation, and the particle size uniformity of the obtained nanoparticles is poor, and the particle size range is between 50 and 200.

Method used

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  • Method for preparing curcumin lipid nano-particle suspension or nano-particles
  • Method for preparing curcumin lipid nano-particle suspension or nano-particles
  • Method for preparing curcumin lipid nano-particle suspension or nano-particles

Examples

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preparation example Construction

[0027] A kind of preparation method of curcumin lipid nanoparticle suspension or nanoparticle, the method comprises the following steps:

[0028] A, adding 1 weight part of curcumin and 5 to 20 weight parts of amphoteric degradable polymers into organic solvents for dissolution to form a lipid phase solution;

[0029] B. Add 5-20 parts by weight of surfactant into water to dissolve to form an aqueous phase solution;

[0030] C. Then inject the lipid phase solution and the water phase solution into the microchannel of the channel reactor so that the lipid phase solution and the water phase solution are mixed into granules in the microchannel reactor, and the flow rate of the water phase is controlled to be 0.65 ~ 0.75mL / min The flow rate of the lipid phase is 0.2-0.5mL / min, and then the organic solvent is removed to obtain the curcumin lipid nanoparticle suspension.

[0031] Preferably, the flow rate of the aqueous phase is 0.68-0.7 mL / min; the flow rate of the lipid phase is ...

Embodiment 1

[0035] Precisely weigh 0.75 mg of curcumin and 10 mg of PLGA and dissolve them in 10 mL of acetone solvent to prepare a lipid phase solution for subsequent use;

[0036] At the same time, weigh 10 mg of poloxamer (P-188) and dissolve it in ultrapure water to prepare an aqueous phase solution for later use;

[0037] Then inject the lipid phase solution and the aqueous phase solution into the microchannel of the microchannel reactor to make the lipid phase solution and the aqueous phase solution mix and granulate in the microchannel reactor, and control the flow rate of the aqueous phase to be 0.65mL / min; The flow rate is 0.5mL / min, collects effluent, removes organic solvent again, obtains curcumin lipid nanoparticle suspension. According to the corresponding detection, the average encapsulation efficiency of the curcumin lipid nanoparticle suspension was 94.92±0.28%, the average particle size was 107.5±1.18nm, the Zeta potential was -25.30mV, and the drug loading was 1.02%.

Embodiment 2

[0039] Precisely weigh 0.75 mg of curcumin and 3.75 mg of m-PLGA and dissolve them in 10 mL of ethanol solvent to prepare a lipid phase solution for later use;

[0040] At the same time, 3.75 mg of PVA was weighed and dissolved in ultrapure water to prepare an aqueous phase solution for subsequent use;

[0041] Then inject the lipid phase solution and the aqueous phase solution obtained above into the microchannel of the microchannel reactor so that the lipid phase solution and the aqueous phase solution are mixed and granulated in the microchannel reactor, and the flow rate of the water phase is controlled to be 0.75mL / min The flow rate of the lipid phase is 0.4mL / min, the effluent is collected, and the organic solvent is removed to obtain a curcumin lipid nanoparticle suspension. According to the corresponding detection, the average encapsulation efficiency of the curcumin lipid nanoparticle suspension was 91.22±0.52%, the average particle size was 105.9±1.68nm, the Zeta pot...

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Abstract

The invention relates to a method for preparing a curcumin lipid nano-particle suspension or nano-particles, and belongs to the technical field of medicinal preparations. The method for preparing the curcumin lipid nano-particle suspension or nano-particle aims to solve existing problems of difficult operation, poor encapsulation rate and large particle diameter, and comprises the following steps: dissolving 1 part by weight of curcumin and 5-20 parts by weight of amphoteric degradable high-molecular polymer into an organic solvent to form a lipid phase solution; dissolving 5-20 parts by weight of surfactant in water to form an aqueous phase solution; injecting the lipid phase solution and the aqueous phase solution into a micro-passage of a passage reactor to mix the lipid phase solution and the aqueous phase solution into particles, wherein the aqueous phase flow velocity is 0.65-0.75mL / min, and the lipid phase flow velocity is 0.2-0.5mL / min; removing the organic solvent to obtain the curcumin lipid nano-particle suspension. The method has the effects of being simple in process, easy to operate, high in drug encapsulation rate, small in particle diameter and high in uniformity.

Description

technical field [0001] The invention relates to a preparation method of curcumin lipid nanoparticle suspension or nanoparticle, and belongs to the technical field of pharmaceutical preparations. Background technique [0002] With the continuous development and progress of science and technology, the emergence of new dosage forms of nano-medicines has made it possible to effectively deliver water-insoluble drugs. The nano drug delivery system has targeting selectivity to tumor cells. It maximizes drug concentration while protecting surrounding healthy tissue. In the past decades, many formulation approaches have been proposed to deliver poorly water-soluble drugs, such as molecular complexes, polymer micellar systems, nanosuspensions, liposomes, and chemically modified prodrugs, etc. As a new drug carrier, biodegradable solid nanoparticles have attracted much attention because of their high biocompatibility, non-toxicity, long-term stability, considerable physiological prop...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K9/14A61K31/12A61J3/02A61P29/00A61P31/04A61P35/00
Inventor 郭钫元严琴英郭定佳洪伟勇杨根生
Owner 浙江佳泰科技有限公司
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