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New compound silver sulfadiazine suspension and preparation method thereof

A technology of silver sulfadiazine and suspension, applied in the field of medicine, can solve the problems of difficult control of drug dosage, unsatisfactory suspension effect, slow growth of granulation tissue and the like

Active Publication Date: 2015-04-22
滨州医学院附属医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, each dosage form has advantages and disadvantages: using dry powder or making a paste before medication, the dosage of the drug is not easy to control, and the wound surface is more irritating; Poor air permeability, easy to cause skin corruption
But also there are following problems: after the suspension is placed for a period of time, there are drug properties unstable, and the suspension effect is still unsatisfactory. After the sedimentation occurs, some drugs are easily bonded into lumps after re-shaking, and it is not easy to disperse evenly. In the process of clinical application, there are shortcomings of uneven coating
In addition, after the application of this drug, although the wound surface dries and scabs quickly, the new granulation tissue on the wound surface grows slowly, which leads to prolonged hospitalization, greatly increases hospitalization expenses, and increases the burden on patients.

Method used

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  • New compound silver sulfadiazine suspension and preparation method thereof
  • New compound silver sulfadiazine suspension and preparation method thereof
  • New compound silver sulfadiazine suspension and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0115] Each 1000ml contains 50g of silver sulfadiazine, 1g of chlorhexidine acetate, 40g of starch, 2.5g of methylcellulose, 25g of vitamin E, and the balance is purified water.

[0116] The preparation method is as follows: weigh the methyl cellulose according to the dosage relationship, add 100ml of purified water, stir evenly, let it stand for 3 hours, make it fully expand, and obtain the methyl cellulose solution A;

[0117] Weigh the starch according to the dosage relationship, add 100ml of purified water, stir evenly, and let it stand for 2 hours to fully expand to obtain liquid B;

[0118] Weigh chlorhexidine acetate according to the dosage relationship, dissolve it in about 100ml of freshly boiled purified water, let it cool, and obtain liquid C;

[0119] Stir liquid B evenly, add 700ml of boiled purified water at a rate of 200ml per minute to liquid B under stirring, stir until translucent viscous liquid, cool in a water bath for 5-7min to 30-35°C while stirring , to...

Embodiment 2

[0127] Each 1000ml contains 45g of silver sulfadiazine, 1.1g of chlorhexidine acetate, 35g of starch, 2.45g of methylcellulose, 20g of vitamin E, and the balance is purified water.

[0128] The preparation method is as follows: weigh the methyl cellulose according to the dosage relationship, add 90ml of purified water, stir evenly, let it stand for 2 hours, make it fully expand, and obtain the methyl cellulose solution A;

[0129] Weigh the starch according to the dosage relationship, add 110ml of purified water, stir evenly, and let it stand for 1.5 hours to fully expand to obtain liquid B;

[0130] Weigh chlorhexidine acetate according to the dosage relationship, dissolve it in about 90ml of freshly boiled purified water, let it cool, and obtain liquid C;

[0131] Stir liquid B evenly, add 700ml of boiled purified water at a rate of 200ml per minute to liquid B under stirring, stir until translucent viscous liquid, cool in a water bath for 5-7min to 30-35°C while stirring ,...

Embodiment 3

[0139] Each 1000ml contains 55g of silver sulfadiazine, 0.9g of chlorhexidine acetate, 45g of starch, 2.55g of methylcellulose, 25g of vitamin E, and the balance is purified water.

[0140] The preparation method is as follows: weigh the methyl cellulose according to the dosage, add 110ml of purified water, stir evenly, let it stand for 4 hours to fully expand, and obtain the methyl cellulose solution A;

[0141] Weigh the starch according to the dosage relationship, add 110ml of purified water, stir evenly, and let it stand for 2.5 hours to fully expand to obtain liquid B;

[0142] Weigh chlorhexidine acetate according to the dosage relationship, dissolve it in about 110ml of freshly boiled purified water, let it cool, and obtain liquid C;

[0143] Stir liquid B evenly, add 650ml of boiled purified water at a rate of 200ml per minute to liquid B under stirring, stir until translucent viscous liquid, cool in a water bath for 5-7min to 30-35°C while stirring , to obtain starch...

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Abstract

The invention belongs to the technical field of medicine, and particularly relates to a new compound silver sulfadiazine suspension and a preparation method thereof. 1,000 mL of new compound silver sulfadiazine suspension comprises 45-55g of silver sulfadiazine, 0.9-1.1g of chlorhexidine acetate, 35-45g of starch, 2.45-2.55g of methyl cellulose, 20-25g of vitamin E, and purified water as balance. The new compound silver sulfadiazine suspension has improved drug stability and clinical curative effect, reduces hospitalization time of patients, and maximally reduces hospitalization cost of patients.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to a new compound silver sulfadiazine suspension and a preparation method thereof. Background technique [0002] Burns and scalds are common clinical diseases and frequently-occurring diseases. The main signs are redness, swelling, heat, pain, blisters, obvious edema, and eschar formation. Traditional treatment methods mostly use moist burn ointment for topical application. There are also many units that use different dosage forms of silver sulfadiazine to treat burns and scalds. At first, the dry powder was directly sprinkled on the wound surface or the fine powder of silver sulfadiazine was adjusted into a paste with 0.9% sodium chloride to make a suspension, cream or ointment; in recent years, some scholars have also made it into a glue and gel agents, biofilm agents, etc. However, each dosage form has advantages and disadvantages: using dry powder or making a paste before me...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/63A61K9/10A61K47/38A61K47/36A61P17/02A61K31/155A61K31/355
Inventor 丁长玲丁召兴陈步凤刘呈华崔光怀马静
Owner 滨州医学院附属医院
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