Traditional Chinese medicinal composition for treating chronic colitis and preparation and application thereof

A technology for chronic colitis and pharmaceutical preparations, applied in the field of medicine, can solve the problems of confusion of treatment principles and methods, difficult choices for clinicians and patients, and achieve the effects of relieving symptoms, improving gastrointestinal function, and regulating physical fitness.

Inactive Publication Date: 2014-05-14
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are many kinds of Chinese patent medicines for the treatment of chronic colitis on the market, but there are few medicines with

Method used

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  • Traditional Chinese medicinal composition for treating chronic colitis and preparation and application thereof
  • Traditional Chinese medicinal composition for treating chronic colitis and preparation and application thereof
  • Traditional Chinese medicinal composition for treating chronic colitis and preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1: preparation pharmaceutical composition of the present invention

[0024]

[0025] Put the above composition in a container, add water until the water surface is 2 to 3 cm higher than the surface of the medicinal material, decoct twice with a slow fire, the first time for 1 hour, and the second time for 0.5 hours, combine the two extracts, concentrate to a relative density of 1:1, That is, oral liquid medicine is obtained.

Embodiment 2

[0026] Embodiment 2: the optimal extraction process of Chinese medicine composition of the present invention

[0027] The concrete formula of Chinese medicine composition of the present invention is:

[0028] Coix seed 20g, Codonopsis 15g, white cardamom 10g, Phellodendron 9g, red rattan 10g, black medicine 9g, notopterygium 10g, ebony plum 9g, red stone fat 30g, weigh 9 parts in parallel.

[0029] Orthogonal experiment design was used to optimize the optimal extraction process of the prescription.

[0030] (1) Extraction process conditions and investigation plan

[0031] Taking the content of berberine and isoimperatorin in the extract and the yield of the extract as indicators, L 9 (3 4 ) Orthogonal experiment design table to investigate the influence of solvent dosage, extraction time, extraction times, alcohol concentration and other factors on the extraction effect, in order to optimize the best extraction process. See Table 1 for factor levels.

[0032] Table 1 Orth...

Embodiment 3

[0051] Embodiment 3: Chinese medicine compound extract of the present invention

[0052] Weigh 300g of coix seed, 225g of Codonopsis pilosula, 150g of white cardamom, 135g of Phellodendron cortex, 150g of red rattan, 135g of black medicine, 150g of notopterygium, 135g of ebony plum, 450g of red stone fat, add 8 times the amount of water and decoct twice. After 1 hour, combine the decoction and filter to obtain the extract, concentrate the extract to a relative density of 1:1.08-1.10 (90-95°C), cool to room temperature, add 95% ethanol to adjust the ethanol concentration to 70% , stand at 4°C for 24 hours, filter off the precipitate, recover the ethanol from the filtrate under reduced pressure, concentrate it to the extract with a relative density of 1:1.25-1.30 (50-60°C), then dry it under reduced pressure at 60°C and 1MPa to obtain the extract Dry extract 180g.

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Abstract

The invention relates to the technical field of medicine, and particularly relates to a traditional Chinese medicinal composition for treating chronic colitis and a preparation and application thereof. The traditional Chinese medicinal composition comprises the following raw materials in parts by weight: 15-40 parts of Coix lacryma-jobi seed, 10-30 parts of Radix codonopsis, 6-20 parts of Amomum cardamomum, 3-15 parts of cortex phellodendri, 6-20 parts of Sargentodoxa cuneata stem, 3-15 parts of Lindera aggregata, 6-20 parts of notopterygium root, 3-15 parts of smoked plum, and 10-60 parts of red halloysite. The invention also provides a medicine preparation taking the traditional Chinese medicinal composition as an active ingredient. Pharmacodynamic experiments show that the traditional Chinese medicinal composition provided by the invention has the remarkable curative effect on a chronic ulcerative colitis animal model. Through clinical trials, the effective rate for treating chronic ulcerative colitis is 95%, and the effective rate for treating chronic non-ulcerative colitis is 90%, which have statistically significant difference compared with a control group.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a traditional Chinese medicine composition for treating chronic colitis, its preparation and application. Background technique [0002] Chronic colitis is a common multiple intestinal disease with the colon, sigmoid colon and rectum as the diseased parts. The main symptoms of the disease are left lower abdominal pain, diarrhea, tenesmus, mucus in the stool, constipation or diarrhea alternately Happens, good and bad. The course of the disease is protracted and difficult to heal, ranging from several months to decades. 80% of patients will relapse and aggravate the disease. The canceration rate of patients with a 30-year course of disease can be as high as 40%. Therefore, it is defined as 14 refractory by the World Health Organization. one of the diseases. The incidence rate of chronic colitis in my country is about 5-40 / 100,000. Mental factors, excessive fatigue, improper diet ...

Claims

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Application Information

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IPC IPC(8): A61K36/9064A23L1/29A61P1/00A61K33/26A23L33/00
Inventor 刘继勇蔡溱顾清高申虞慧华尤本明潘勇华
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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