The invention relates to a medicine for treating stubborn acne, which comprises the following active ingredients in parts by weight: Eriobotrya japonica leaf 18-21 parts, Morus alba leaf 17-20 parts, Morus alba bark 18-22 parts, Flos Lonicerae 20-24 parts, Herba Taraxaci 15-20 parts, Forsythia suspensa 10-15 parts, Cortex Phellodendri 8-12 parts, Angelica sinensis 20-25 parts, Ligusticum chuanxiong 10-12 parts, Radix Paeoniae Rubra 8-12 parts, Cortex Moutan Radicis 9-13 parts, Carthamus tinctorius flower 8-11 parts, Eupolyphaga seu steleophaga 9-12 parts, Herba Artemisiae Scopariae 17-20 parts, Coix lacryma-jobi seed 18-20 parts, Eupatorium fortunei 8-10 parts, Radix Et Rhizoma Rhei 14-16 parts, Oldenlandia diffusa 15-17 parts, Gleditsia sinensis spine 10-18 parts, Chrysanthemum indicum flower 10-16 parts, Corydalis bungeana 20-25 parts, Sophora japonica 12-15 parts, Alisma orientalis 14-20 parts, and fructus crataegi 12-15 parts. The medicine has effects of clearing away heat and toxic materials, dispelling blood stasis, reducing the stagnation, dredging the channels, regulating internal organs and balancing ying and yang, and has the advantages of good curative effect, no recurrence, no scar left and no toxic or side effect.