The invention provides oriental cockroach wine for treating traumatic injury and a preparation method of the oriental cockroach wine, and belongs to the technical field of health-care wine. The oriental cockroach wine is prepared from the following raw materials in parts by weight: 70-85 parts of oriental cockroach, 20-30 parts of papilionaceae crotalaria assamica, 20-30 parts of memecylon ligustrifolium, 12-25 parts of roots or root bark of ampelopsis heterophylla, 8-12 parts of murraya paniculata, 18-24 parts of roots of helwingia japonica, 9-16 parts of roots of urena procumbens, 15-25 parts of Japanese pollia herbs, 40-60 parts of stichopus japonicus, 12-20 parts of cynanchum mooreanum, 12-20 parts of herba adiantumcapillus-veneris, 9-16 parts of roots, twigs or leaves of campylotropis macrocarpa, 9-16 parts of aegilops squarrosa, 9-16 parts of coelogyne cristata, 7-15 parts of himalayan teasel roots and 5000-6000 parts of white spirit. According to the oriental cockroach wine disclosed by the invention, through the pharmacology functions of promoting diuresis, eliminating dampness, expelling blood stasis, eliminating stagnation, strengthening waist and the kidney, promoting blood circulation, relaxing muscles and tendons, and setting the tendons and bones, the purpose of treating traumatic injury is realized. Through clinical verification, the oriental cockroach wine is small in toxic and / or side effects, takes effect quickly, and is high in cure rate, and broad in adaptability, and the effective rate can achieve 99%.