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Job's tears nut oil self-emusifying preparation and its making method

Coix seed oil, self-emulsification technology, applied in anti-inflammatory agents, pharmaceutical formulations, emulsion delivery, etc., to achieve the effects of improving stability, promoting absorption, and accurate quantification

Inactive Publication Date: 2007-09-05
江苏圣典医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the problems existing in the existing coix seed oil oral dosage form, and provide a coix seed oil self-emulsifying preparation with high bioavailability, good stability, good taste, and safe and convenient administration

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1: Coix seed oil self-emulsifying soft capsule preparation one

[0025] Coix Seed Oil 650g

[0026] Tween-85 350g

[0027] Soft capsule capsule material: add an appropriate amount of gelatin into the sol tank, add an appropriate amount of water at 60-80°C, add preservatives, sunscreens and colorants if necessary, seal it and heat it at the same time, stir until it melts and swells completely, then add an appropriate amount of glycerin , seal the glue tank, turn off the stirring, turn on the vacuum pump, evacuate, and wait for the air bubbles to be exhausted to obtain the gelatin solution. Keep warm at 50-70°C for later use.

[0028] Take coix seed oil and Tween-85 and put them in the same container and ultrasonically stir and mix them evenly to form a homogeneous solution, which is the self-emulsifying drug release drug solution of coix seed oil. The soft capsule material and coicis seed oil self-emulsifying drug release liquid are taken, put into a soft caps...

Embodiment 2

[0030] Example 2: Coix seed oil self-emulsifying soft capsule preparation two

[0031] Coix Seed Oil 550g

[0032] Soy Lecithin 125g

[0033] Glycerin 50g

[0034] Sorbitol 75g

[0035] Vitamin E 50g

[0036] Polyethylene glycol-400 150g

[0037] Soft capsule capsule material embodiment 1 is identical.

[0038] Take coix seed oil, soybean lecithin, glycerin, sorbitol, vitamin E and polyethylene glycol-400, mix them, put them in the same container and ultrasonically stir and mix them evenly to form a uniform solution, that is, a self-emulsifying drug release drug solution of coix seed oil. The soft capsule material and coicis seed oil self-emulsifying drug release liquid are taken, put into a soft capsule machine and adopt the compression method to prepare soft capsules, dry, wash, dry again, sort and pack, and obtain finished products.

[0039] Take 0.5ml of the coix seed oil self-emulsifying drug release solution, add it to 10ml of artificial gastric juice, stir gently wi...

Embodiment 3

[0040] Example 3: Coix seed oil self-emulsifying liquid capsule preparation one

[0041] Coix Seed Oil 750g

[0042] Lecithin 100g

[0043] Polyoxyethylene Nonylphenol Ether 150g

[0044] Glycerin 50g

[0045] Take emulsifier-OP (polyoxyethylene nonylphenol ether, molecular weight 648.85), add lecithin and glycerin, stir to mix evenly, then add coix seed oil, stir at high speed to mix evenly, and obtain coix seed oil self-emulsifying concentrate . The coix seed oil self-emulsifying concentrated solution is directly filled into the liquid capsule shell to obtain a liquid capsule, which is sorted and packaged to obtain a finished product.

[0046] Take 0.5ml of the self-emulsifying concentrated solution of coix seed oil, add it to 10ml of artificial gastric juice, stir gently with a glass rod, and a blue opalescent emulsion can be formed rapidly. The particle size of the emulsion was measured with a TSM ultrafine particle size analyzer, and the result was that the average p...

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Abstract

A self-emulsifying product of coix seed oil in the orally taken forms, such as softgel, liquid capsule, solid capsule, particle, etc, is proportionally prepared from coix seed, emulsifier, disperser, emulsifying aid, and solid adsorbent. It can be emulsified by itself in gastrointestinal tract for higher biologic utilization rate and higher curative effect. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to a coix seed oil self-emulsifying preparation and a preparation method thereof. Background technique [0002] Coix seed is the dry mature seed kernel of grass Coix lacrymajoib L.var.mayuen (Roman.) Stapf. Cool in nature, sweet in taste and light in taste, it has the effects of invigorating the spleen and expelling dampness, clearing away heat and expulsion of pus, eliminating numbness and stopping diarrhea. Modern pharmacological studies of coix seed have shown that coix seed has the functions of improving immune function, lowering blood sugar, analgesic, anti-inflammatory, anti-thrombosis, and anti-tumor. Coix seed is not only a medicine but also a good food therapy. As a commonly used traditional Chinese medicine, its use is becoming more and more extensive, especially in recent years, coix seed has been widely used in the treatment of cancer, and good ...

Claims

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Application Information

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IPC IPC(8): A61K36/8994A61K9/107A61K47/44A61K47/34A61K47/24A61K47/20A61K47/14A61K47/10A61P37/04A61P29/00A61P7/02A61P3/10A61K47/26
Inventor 吴敏李颖黄光华
Owner 江苏圣典医药科技有限公司
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