Method for simulated moving bed chromatography-based resolution of propranolol enantiomer

Abstract

The invention discloses a method for simulated moving bed chromatography-based resolution of a propranolol enantiomer. The method is characterized in that through a simulated moving bed chromatography system, a propranolol enantiomer is resolved under the normal phase conditions in the presence of cellulose-tris(3,5-dimethylphenylcarbamate) as a filler and n-hexane and alcohol organic modifiers as mobile phases so that high-purity R-propranolol and S-propranolol are obtained. The simulated moving bed chromatography system has the advantages of continuous production, high automation degree and high production efficiency.

Description

technical field [0001] The invention relates to a separation technology of chiral drugs, in particular to a simulated moving bed chromatographic separation method of propranolol. Background technique Propranolol, its molecular structural formula is: Propranolol, also known as propranolol, is a commonly used beta-receptor blocker in clinical practice. It can be used for the treatment of angina pectoris and high blood pressure. From the perspective of chemical structure, propranolol has a chiral carbon atom and has two isomers. Studies have confirmed that S-propranolol has a β-receptor blocking effect about 100 times stronger than R-propranolol. , but the current medicinal use is its racemic form, which often brings side effects while treating heart system diseases. In addition, studies have reported that R-propranolol has a contraceptive effect. Therefore, the chiral resolution of the drug has great practical significance. Contents of the invention The purpose...

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