Method for simulated moving bed chromatography-based resolution of propranolol enantiomer
A technology for simulating moving bed and propranolol is applied in the field of simulated moving bed chromatographic separation of propranolol, which can solve problems such as side effects, and achieve the effects of stable product quality and simple process.
Inactive Publication Date: 2014-05-14
JIANGSU HANBON SCI & TECH CO
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From the perspective of chemical structure, propranolol has a chiral carbon atom and has two isomers. Studies have confirmed that S-propranolol has a β-receptor blocking effect about 100 times stronger than R-propranolol. , but the current medicinal use is its racemic form, which often brings side effects while treating heart system diseases
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Abstract
The invention discloses a method for simulated moving bed chromatography-based resolution of a propranolol enantiomer. The method is characterized in that through a simulated moving bed chromatography system, a propranolol enantiomer is resolved under the normal phase conditions in the presence of cellulose-tris(3,5-dimethylphenylcarbamate) as a filler and n-hexane and alcohol organic modifiers as mobile phases so that high-purity R-propranolol and S-propranolol are obtained. The simulated moving bed chromatography system has the advantages of continuous production, high automation degree and high production efficiency.
Description
technical field [0001] The invention relates to a separation technology of chiral drugs, in particular to a simulated moving bed chromatographic separation method of propranolol. Background technique Propranolol, its molecular structural formula is: Propranolol, also known as propranolol, is a commonly used beta-receptor blocker in clinical practice. It can be used for the treatment of angina pectoris and high blood pressure. From the perspective of chemical structure, propranolol has a chiral carbon atom and has two isomers. Studies have confirmed that S-propranolol has a β-receptor blocking effect about 100 times stronger than R-propranolol. , but the current medicinal use is its racemic form, which often brings side effects while treating heart system diseases. In addition, studies have reported that R-propranolol has a contraceptive effect. Therefore, the chiral resolution of the drug has great practical significance. Contents of the invention The purpose...
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IPC IPC(8): C07C217/30C07C213/10
Inventor 张大兵张宁刘玉明罗军侠
Owner JIANGSU HANBON SCI & TECH CO
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