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Preparation method of synthetic oxytocin

Oxytocin, a preparation-type technology, applied in the field of preparation of synthetic oxytocin, can solve the problems of cumbersome operation, many steps, low efficiency, etc., and achieve the effect of stable product quality and simple process

Inactive Publication Date: 2014-05-14
JIANGSU HANBON SCI & TECH CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Other documents also have reported methods for preparing oxytocin, most of which have many steps, complicated operations and low efficiency

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0008] A preparative high-performance liquid chromatography separation and purification system is adopted. The column size is Φ100×300mm, and the mixture of water and acetonitrile is used as the mobile phase for elution. Water / acetonitrile=1 / 1, the flow rate is 200ml / min, and the column packing is reverse Phase C18 filler, filler particle size 10um, system temperature 30°C. The detection wavelength of the ultraviolet photometric detector used is 220nm, and the synthetic uterine is collected, and the purity is ≥99.1% through HPLC analysis.

Embodiment 2

[0010] A preparative high-performance liquid chromatography separation and purification system is adopted. The column size is Φ150×300mm, and the mixture of water and acetonitrile is used as the mobile phase for elution. Water / acetonitrile=1 / 1, the flow rate is 300ml / min, and the column packing is reverse Phase C18 filler, filler particle size 10um, system temperature 30°C. The detection wavelength of the ultraviolet photometric detector used is 220nm, and the synthetic uterine is collected, and the purity is ≥99.3% through HPLC analysis.

Embodiment 3

[0012] A preparative high performance liquid chromatography separation and purification system is adopted, the column size is Φ200×300mm, and the mixture of water and acetonitrile is used as the mobile phase for elution, water / acetonitrile=1 / 1, the flow rate is 500ml / min, and the column packing is reverse Phase C18 filler, filler particle size 10um, system temperature 30°C. The detection wavelength of the ultraviolet photometric detector used is 220nm, and the synthetic uterine is collected, and the purity is ≥99.1% through HPLC analysis.

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Abstract

The invention discloses a preparation method of synthetic oxytocin. The preparation method utilizes a preparation-type high-performance liquid chromatography separation purification system, utilizes reversed-phase C18 as a filling material and utilizes water and acetonitrile as mobile phases. The preparation method of the synthetic oxytocin has the advantages of simple processes, less experiment steps, low cost, short period and purity more than 99.0%.

Description

technical field [0001] The invention relates to a preparation method of medicine, in particular to a preparation method of synthesizing oxytocin. Background technique [0002] Synthetic oxytocin is also known as 3-isoleucine-8-leucine and synthetic oxytocin. It can indirectly stimulate the contraction of uterine smooth muscle, simulating the uterine contraction of normal childbirth, leading to cervical dilatation, and the uterine response to oxytocin gradually increases during pregnancy and reaches its peak at full term. ② Stimulate the smooth muscle contraction of the mammary gland, which helps milk to be discharged from the breast, but does not increase the milk secretion of the mammary gland. [0003] Patent 200810084940.8 discloses a preparation method of oxytocin. The method firstly synthesizes intermediate A and intermediate B respectively, and then uses diphenylphosphoric azido as a condensing agent, in the presence of DMF, DPPA, dioxane, piperidine, TFA and DCM, th...

Claims

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Application Information

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IPC IPC(8): C07K7/16C07K1/20
Inventor 祁威王亚辉王瑊
Owner JIANGSU HANBON SCI & TECH CO
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