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Eu-commin intragastric administration agent for cows and preparation method thereof

A technique of eucommia and gavage is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, drug delivery, etc. It can solve the problems of inconvenient gavage use, adverse effects on the body of dairy cows, etc., and achieves improved preservation rate and long shelf life. Effect

Inactive Publication Date: 2014-05-28
ZHANGJIAJIE EVERGREEN BIOLOGICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As it is a feed additive, long-term adaptation will inevitably have adverse effects on the longevity of dairy cows
If used alone as a drug, it is a powder, which is inconvenient to use by gavage

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Pick 100kg of fresh Eucommia leaves in Jiangya Forest Farm, the main production area of ​​Eucommia in Cili County, Zhangjiajie City, Hunan Province, in mid-June, and bake them at 65-70°C for 10 hours on the same day to obtain 28.5kg of Eucommia roasted leaves. Put the roasted leaves into a 500L stainless steel extraction tank, add 285L of purified water, heat to 60°C with steam, stir and extract for 2 hours, filter the extraction liquid, pump it into the storage tank, add 285L of purified water for secondary extraction, and combine to obtain the extraction Liquid 520L, fine filtration, fine filtrate into the clarification tank, add chitosan 25g, stir for 30min, overnight static precipitation; clarified liquid is separated by roll-type ultrafiltration membrane, membrane module molecular weight cut-off is 50000, and ultrafiltration dialysate 485L is obtained, ultrafiltration The dialysate was separated and concentrated by a roll-type nanofiltration membrane. The molecular ...

Embodiment 2

[0024] Put 30kg of roasted Eucommia leaves produced in Zunyi, Guizhou Province in mid-July, into a 500L stainless steel extraction tank, add 360L of purified water, heat to 50°C with steam, stir and extract for 1.5h, filter the extract, pump it into the storage tank, add 360L purified water for secondary leaching, combined to obtain 550L of extracts, fine filtration, fine filtrate into a clarification tank, add 1100g of diatomaceous earth, 20g of chitosan, stir for 30min, and settle overnight; Separation, the molecular weight cut-off of the membrane module is 100000, and 512L of ultrafiltration dialysate is obtained. The ultrafiltration dialysate is separated and concentrated by roll-type nanofiltration membrane. ml, total flavonoids 17.64mg / ml, polysaccharides 60.28mg / ml. The quality-inspected nanofiltration concentrate was sterilized at high temperature for 10 minutes, and then entered into the filling machine for quantitative filling; every 500ml / bottle was affixed with a p...

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PUM

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Abstract

The invention provides an eu-commin intragastric administration agent for cows and a production method thereof. The production method comprises the following steps: dry eucommia leaves are extracted twice continuously, and each time extraction time is 1.5-2 h; an extract liquid is subjected to stilling and precipitating by a natural clarifying agent, supernate is pumped out, lower suspension is centrifugalized, and filtrate is mixed with the supernate; an ultrafiltration membrane is separated, then a dialyzate over-wind type nanofiltration membrane is separated and condensed, dialyzate is pumped in an extracting tank for recycling, and trapped fluid is condensed till the concentration is 20-30%; nanofiltration trapped fluid is pumped in a high-temperature instant sterilization machine for sterilization, and enters into a filling machine for filling under the sterile condition. The eu-commin intragastric administration agent can enhance the immunity of the organism of the cows, effectively controls the recessive mastitis and the clinical mastitis, can reduce the somatic cell counts of the cows remarkably, improves the tendency of milk production, and has no remarkable influence on the fermentation function of cow rumen, the butter-fat content and the milk protein rate. Meanwhile, the eu-commin intragastric administration agent is an aqueous solution, is convenient to use, and has no side effects.

Description

technical field [0001] The invention relates to pharmaceutical products for animals, and in particular provides a cow-specific eucommia gavage agent for preventing and controlling cow mastitis and somatic cell count and a preparation method thereof. Background technique [0002] Cow mastitis is a common disease in dairy farming. Scientific research shows that one-third of the 200 million dairy cows in the world suffer from mastitis, causing an annual loss of about 30 billion U.S. dollars, and the annual loss in my country is more than 10 billion yuan. The symptoms of dairy cow mastitis are inflammation of the udder parenchyma and interstitium. The etiology is mostly caused by mechanical stimulation, infiltration of pathogenic microorganisms, and chemical and physical damage. The symptoms include clinical mastitis and recessive mastitis. Various degrees of swelling, pain, reduced milk production, milk denaturation, somatic cell count surge, etc., seriously affect the health ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/46A61K9/08A61P15/14A61K127/00
Inventor 符星辉符立新彭密军于华忠王文茂田春莲
Owner ZHANGJIAJIE EVERGREEN BIOLOGICAL SCI
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