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A pharmaceutical composition containing an analgesic and fospropofol disodium

A technology of fospropofol sodium and its composition, which is applied in the field of compound fospropofol sodium injection and its preparation, can solve the problems of weak analgesic effect, short duration, insoluble in water, etc., and achieve enhanced analgesic effect , reduce the frequency of administration, and reduce the effect of adverse reactions

Inactive Publication Date: 2014-05-28
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Propofol is a short-acting phenolic alkanes drug with quick onset, short duration, quick and stable recovery, but weak analgesic effect and insoluble in water. It is clinically used as an emulsion with poor stability

Method used

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  • A pharmaceutical composition containing an analgesic and fospropofol disodium
  • A pharmaceutical composition containing an analgesic and fospropofol disodium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Alfentanil 5mg

[0026] Fospropofol Sodium 2500mg

[0027] Sodium chloride 9mg

[0028] Add water for injection to 10ml

[0029] Add accurate prescription amounts of sodium chloride, alfentanil and fospropofol sodium into the liquid preparation container, add 10ml of sterilized water for injection, stir to dissolve, add appropriate amount of 0.1mol / L hydrochloric acid to adjust the pH value to 6.0-7.0 , then add 0.05% (W / V) medicinal charcoal, stir for 30 minutes, decarburize by coarse filtration with a sand filter, and fine filter with a 0.22 μm microporous membrane until the clarity is qualified, and the fixed amount is divided into ampoules medium, autoclave at 121°C for 1 hour to obtain.

Embodiment 2

[0031] Remifentanil 5mg

[0032] Fospropofol Sodium 3500mg

[0033] Sodium chloride 9mg

[0034] Add water for injection to 10ml

[0035] Add glucose, remifentanil and fospropofol sodium in the exact prescribed amount into the liquid preparation container, add 10ml of sterile water for injection, stir to dissolve, add an appropriate amount of 0.1mol / L hydrochloric acid to adjust the pH value to 6.0-7.0, Then add 0.05% (W / V) medicinal charcoal, stir for 30 minutes, decarburize by coarse filtration with a sand filter, and fine filter with a 0.22 μm microporous membrane until the clarity is qualified, and the fixed amount is divided into ampoules , autoclaved at 121 ° C for 1 hour, that is.

Embodiment 3

[0037] Fentanyl 5mg

[0038] Fospropofol Sodium 5000mg

[0039] Sodium chloride 9mg

[0040] Add water for injection to 10ml

[0041]Add glucose, fentanyl and fospropofol sodium in the exact prescription amount into the liquid preparation container, add 10ml sterile water for injection, stir to dissolve, add an appropriate amount of 0.1mol / L hydrochloric acid to adjust the pH value to 6.0-7.0, and then Add 0.05% (W / V) medicinal charcoal, stir for 30 minutes, decarburize by coarse filtration with a sand filter, and fine filter with a 0.22 μm microporous membrane until the clarity is qualified. Autoclave at 121°C for 1 hour to obtain.

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PUM

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Abstract

The invention discloses a pharmaceutical composition containing a non-narcotic analgesic or a narcotic analgesic and pharmaceutically acceptable salts thereof and fospropofol disodium. The non-narcotic analgesic is nefopam hydrochloride or nefopam. The narcotic analgesic is selected from fentanyl, remifentanil, alfentanil and sufentanil. The pharmaceutical composition can be directly used for clinic comprising anesthesia induction, maintenance of anesthesia, post operation or ICU analgesia, and the like. The pharmaceutical composition has functions of analgesia and sedation. Through addition or synergistic effects of medicines, the pharmaceutical effects are enhanced, the dosage is reduced, untoward effects in pain treatment is prevented and relieved, the number of times of administration by an anesthetist is reduced, and therefore an anesthesia induction process is more convenient and an ideal anesthesia effect can be achieved.

Description

technical field [0001] The invention relates to a compound fospropofol sodium injection containing analgesics and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] At present, the induction and maintenance of anesthesia in clinical operations generally use compound anesthesia, that is, the combined use of analgesic and sedative anesthetic drugs, the use of additive or synergistic effects between drugs, reducing the dosage of anesthetic drugs, reducing or avoiding the effects of drugs on the human body. Adverse reactions, so as to achieve a more ideal anesthetic effect. The two drugs usually used in clinical operations must be administered separately through intravenous infusion pumps. However, due to objective conditions, this method of administration is extremely inconvenient in some special environments, such as emergency operations, war wounds, etc. Some patients do not have anesthesia Due to the special environment...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K9/08A61P29/00A61P25/20A61K31/661
Inventor 熊利泽文爱东吴寅李杰刘进贾娜李玉文赵超李锐莉王超
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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