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A polymer film material and a preparation method thereof

A polymer membrane, polymer technology, applied in the field of membrane materials, can solve the problems of affecting the detection results, blood cell destruction, activation, etc.

Active Publication Date: 2014-05-28
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] However, there is no suitable material and method for simultaneously separating red blood cells and platelets from whole blood, and the existing separation process often causes destruction and activation of blood cells, which affects the test results

Method used

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  • A polymer film material and a preparation method thereof
  • A polymer film material and a preparation method thereof
  • A polymer film material and a preparation method thereof

Examples

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preparation example Construction

[0045] The present invention also provides a kind of preparation method of above-mentioned polymer film material, it is characterized in that, comprises the following steps:

[0046] A) Under the action of a photoinitiator, the hydrophilic substance is grafted on the surface of the hydrophobic polymer film to form a polymer film. The polymer film includes a hydrophobic polymer layer and is compounded on the hydrophobic polymer film. a hydrophilic polymer layer on the polymer layer;

[0047] B) Under the action of a photomask, photolithography forms a through hole on the hydrophilic polymer layer of the polymer film, and forms a hydrophilic adhesive on the hydrophilic polymer layer of the polymer film. attached area;

[0048] C) adding functional monomers to the hydrophilic adhesion region under ultraviolet light irradiation to form functional substances, and then immobilizing fibronectin on the functional substances to obtain polymer membrane materials;

[0049] The hydrophi...

Embodiment 1

[0068] The hydrogenated styrene-butadiene-styrene terpolymer SEBS (produced by Kraton, USA, brand 1650) was used as the base material of the hydrophobic polymer film. First, the 5wt% chloroform solution was prepared by the drop film method with an area of ​​3*3cm 2 , a hydrophobic polymer film with a thickness of 100um, and then put the above-mentioned hydrophobic polymer film into the acetone solution of 2wt% benzophenone, soak for 30 minutes, and then place the film on a quartz plate, and put the hydrophilic 2-Methacryloyloxyethylphosphorylcholine (produced in Japan, sold by Nanjing Huizhe Trading Co., Ltd.) was prepared into a 20wt% aqueous solution, which was uniformly added dropwise to the surface of the above-mentioned hydrophobic polymer film. , the dropwise amount is 10mL. After being irradiated under an ultraviolet lamp for 1-3 minutes, rinsed with a large amount of PBS buffer solution to obtain a polymer film.

[0069] Prepare a combined stencil consisting of an up...

Embodiment 2

[0078] The hydrophobic polymer matrix material is changed, and the matrix material is made of polypropylene (PP) and prepared by blown film method. The remaining steps are carried out as described in Example 1.

[0079] The surface of the polymer membrane material after the above-mentioned blood adhesion is observed through an electron microscope, and the red blood cells and platelets have achieved single cell separation, forming red blood cell arrays and platelet arrays respectively.

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Abstract

The invention provides a polymer film material and a preparation method thereof. The polymer film material comprises a hydrophobic polymer layer and a hydrophilic polymer layer. The hydrophilic polymer layer is provided with a hydrophilic adhesive area provided with a functional material fixed to fibronectin. The hydrophilic polymer layer is provided with through holes. The through holes and the hydrophobic polymer layer form a hydrophobic adhesive area. The functional material is a functional monomer or a polymer of the functional monomer. A method of adopting combination of surface grafting and controlled irradiation by utilizing a photomask is adopted, the hydrophilic adhesive area and the hydrophobic adhesive area are formed on the surface of the polymer film and erythrocyte attachment proteins are bonded in the hydrophilic adhesive area, thus obtaining the polymer film material used for separating a single erythrocyte and a single blood platelet from blood.

Description

technical field [0001] The invention belongs to the technical field of membrane materials, and particularly relates to a polymer membrane material and a preparation method thereof. Background technique [0002] In the 1920s, as the development of the petroleum industry promoted the continuous increase of the three types of synthetic materials, the application scope of polymer membrane materials was gradually expanded, and the research on polymer membrane materials gradually became one of the research and development directions in the industry. . In the 1930s, researchers have applied fiber membranes to ultrafiltration separation, ion exchange membranes and point dialysis separation methods appeared in the 1940s, and reverse osmosis membrane separation technology appeared in the 1950s. In the 1960s, scholars in Canada and the United States successfully produced High-efficiency membranes and ultrafiltration membranes. In recent years, with the development of science and tech...

Claims

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Application Information

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IPC IPC(8): B01D71/06B01D69/12B01D69/02B01D67/00C08J7/18
Inventor 石强殷敬华侯建文叶玮杨华伟
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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