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Application of fructose-1, 6-diphosphate in improving anti-hypoxia ability of body

A technology of fructose diphosphate and ability, applied in the field of application of fructose 1,6-diphosphate in improving the body's ability to withstand hypoxia

Inactive Publication Date: 2014-06-04
INST OF HYGIENE & ENVIRONMENTAL MEDICINE PLA ACAD OF MILITARY MEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are no research reports at home and abroad that 1,6-diphosphate fructose can significantly improve the body's ability to withstand high-altitude hypoxia, improve the body's exercise ability and anti-fatigue ability in a high-altitude hypoxic environment

Method used

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  • Application of fructose-1, 6-diphosphate in improving anti-hypoxia ability of body
  • Application of fructose-1, 6-diphosphate in improving anti-hypoxia ability of body
  • Application of fructose-1, 6-diphosphate in improving anti-hypoxia ability of body

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1、1

[0033] Embodiment 1. Effect of fructose 1,6-diphosphate on the body's ability to withstand plateau hypoxia and work capacity

[0034] 1. 62 male Kunming mice were used, and they were fed for 3 days after adoption, and then changed to 15% casein synthetic feed (the feed formula was slightly improved according to AIN-96) for 4 days.

[0035] 2. The mice were randomly divided into 6 groups according to body weight, and three groups were randomly selected (named as Group I, II, and III) twice a day (at 9:00 am and 4:00 pm) with 0.5 ml of normal saline, As a control group; three groups were randomly selected (respectively named as IV, V, and VI groups) twice a day (at 9:00 am and 4:00 pm respectively) with a concentration of 3% fructose 1,6-diphosphate solution 0.5 ml, as the experimental group. Among them, groups I, IV, III and VI had 10 mice in each group, and groups II and V had 11 mice in each group.

[0036] 3. Weigh the body weight of mice in each group twice a week, and th...

Embodiment 2、1

[0064] Anti-fatigue effect of embodiment 2, 1,6-fructose diphosphate

[0065] Currently recognized indicators for evaluating body fatigue are overall evaluation indicators such as blood lactic acid level, blood uric acid nitrogen level, and muscle glycogen level.

[0066] 27 male Kunming mice were selected, adapted to feeding according to the method of Example 1, and randomly divided into three groups, normal group, control group and experimental group, with 9 mice in each group. The mice in the normal group were not gavaged, and the mice in the control group and the experimental group were gavaged and fed according to the method in Example 1. After two weeks, the mice in the control group and the experimental group were put into a low-pressure cabin, and the mice in the simulated 5000 meters After 1 hour of swimming in the low-pressure cabin on the plateau, three groups of mice were killed, blood, liver, skeletal muscle and other tissues were collected, and blood lactic acid,...

Embodiment 3、1

[0075] Example 3, Effect of fructose 1,6-diphosphate on serum, skeletal muscle and liver antioxidant status of hypoxic exercise mice

[0076] Exercise in mice consumes a lot of oxygen, and insufficient oxygen supply under plateau hypoxic conditions can cause insufficient oxidation of the body and changes in the body's antioxidant function, resulting in oxidative stress damage. The following experiments detected the antioxidant indicators malondialdehyde (MDA), total antioxidant capacity (T-AOC), superoxide dismutase (SOD) and glutathione peroxidase ( GSH-Px) levels.

[0077] 27 male Kunming mice were selected, adapted to feeding according to the method of Example 1, and randomly divided into three groups, normal group, control group and experimental group, with 9 mice in each group. The mice in the normal group were not gavaged, and the mice in the control group and the experimental group were gavaged and fed according to the method in Example 1. After two weeks, the mice in ...

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Abstract

The invention discloses application of fructose-1, 6-diphosphate in improving the anti-hypoxia ability of the body. The invention discloses application of fructose-1, 6-diphosphate in preparing products for improving the anti-low oxygen or anti-hypoxia ability of animals. Fructose-1, 6-diphosphate serves as a human body metabolic intermediate, exogenous supplementation of fructose-1, 6-diphosphate can improve the body's resistance to plateau hypoxia, and improve the athletic ability and anti-fatigue ability of the body in a plateau hypoxia environment.

Description

technical field [0001] The invention relates to the application of fructose 1,6-diphosphate in improving the body's resistance to hypoxia. Background technique [0002] Fructose-1,6-diphosphate (FDP) is an intermediate product of intracellular glycolysis, which can directly regulate certain metabolic processes or participate in oxidation and energy supply as a substrate. Under the condition of cellular hypoxia, FDP can stimulate the metabolism of glycolysis pathway to produce lactic acid and ATP to supply the body with energy. Studies have shown that FDP is beneficial to the recovery of fatigue and the improvement of anaerobic capacity in exercise rats, and is conducive to maintaining the integrity and normal function of skeletal muscle mitochondria, and is conducive to the improvement of aerobic exercise capacity in rats; athletes take it before competitions Fructose has a better effect than taking glucose. It can prevent blood sugar from falling during endurance exercise,...

Claims

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Application Information

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IPC IPC(8): A61K31/7024A61P39/00A61P39/06
Inventor 金宏邓炳楠李培兵王永辉
Owner INST OF HYGIENE & ENVIRONMENTAL MEDICINE PLA ACAD OF MILITARY MEDICAL
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