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Preparation method of pharamceutical composition for treating cutaneous pruritus
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A technology of skin itching and composition, applied in the pharmaceutical field, can solve the problems of many contraindications, affecting the normal life and work of patients, and difficult to adhere to the treatment.
Inactive Publication Date: 2014-06-04
ZHANGZHOU PIEN TZE HUANG PHARM
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Problems solved by technology
Western medicine mainly uses antihistamines, opioidreceptor antagonists, procainehydrochloride intravenous closure, etc. for systemic treatment, or externally applied drugs such as doxepin cream, cyproheptadine cream, and glucocorticoid cream for local treatment. Because these drugs have many contraindications, they often cause side effects such as drowsiness and fatigue, which affect the normal life and work of patients, making it difficult to adhere to treatment
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experiment example 1
[0029] Experimental example 1 Chinese medicine composition clinical summary report of the present invention
[0030] Clinical data: 40 patients with skin pruritus came from outpatients of the hospital, including 13 males and 17 females, aged 20-60 years. According to relevant diagnostic criteria in the "Guiding Principles for Clinical Research of New Chinese Medicines", the Chinese medicine composition of the present invention (prepared according to the method of Example 1) is used for treatment after diagnosis.
[0031] Treatment method: take 3-4 tablets each time, three times a day, after meals. If necessary, hydrate with water and apply to the affected area. 7 days is a course of treatment, and one course of treatment is used to determine the curative effect.
[0041]Take the above medicinal materials (except Viper (manufactured) and Pien Tze Huang powder), add water to extract twice, each time for 1 hour (10 times the amount for the first time, 8 times the amount for the second time), filter, and concentrate the combined filtrate to a relative density of 1.15 -1.25 (measured at 40-50°C) to obtain concentrated solution A; Viper (manufactured) was extracted with water twice, each time for 1 hour (the first time was 10 times the amount, the second time was 8 times the amount), filtered, and the filtrates were c...
Embodiment 2
[0043] Embodiment 2 powder of the present invention
[0045] The above-mentioned drugs are added into conventional auxiliary materials, and powders are prepared according to conventional processes.
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Abstract
The invention discloses a preparation method of a pharmaceutical composition for treating cutaneous pruritus. The preparation method comprises the following steps: taking crude drugs except for processed long-noded pit viper and anti-inflammatory and analgesic bolus powder to obtain a concentrated solution A in manners of water extraction and concentration; taking the processed long-noded pit viper to obtain a concentrated solution B in manners of water extraction and concentration; merging the concentrated solution A with the concentrated solution B and futher concentrating to obtain thick paste; adding the anti-inflammatory and analgesic bolus powder and common auxiliary materials to the thick paste; mixing and pelleting; and drying, so as to prepare any clinically acceptable dosage form, for example, an orak solid preparation, a granule, a tablet, a capsule, a medicinal tea, powder, a pill and the like.
Description
technical field [0001] The invention relates to a pharmaceutical composition, its preparation and a preparation method, in particular to a medicinal composition for treating pruritus, its preparation and its preparation method, and belongs to the technical field of pharmacy. This application is a divisional application of the patent application with application number 201210197781.9. Background technique [0002] Pruritus is a common and frequently-occurring disease in dermatology. It refers to a skindisease without primary skin lesions but with pruritus as the main symptom. Changes in skin function and endocrine, allergies, and some diseases such as diabetes, tumors, and kidney failure can all cause skin itching. Western medicine mainly uses antihistamines, opioidreceptor antagonists, procainehydrochloride intravenous closure, etc. for systemic treatment, or externally applied drugs such as doxepin cream, cyproheptadine cream, and glucocorticoid cream for local treatmen...
Claims
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Application Information
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