Doxycycline soluble powder production method

A doxycycline, water-soluble technology, applied in the directions of tetracycline active ingredients, powder delivery, antibacterial drugs, etc., can solve problems such as the limitation of drug administration methods, and achieve the effect of requiring less equipment, simple process, and large market prospects.

Inactive Publication Date: 2014-06-18
QINGDAO BOITE BIOPHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, doxycycline raw powder is a drug that is insoluble in water but only partially soluble in organic solvents, so

Method used

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Examples

Experimental program
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Example Embodiment

[0006] Example 1

[0007] For example, to produce 100 kg of doxycycline soluble powder with a concentration of 45%, first crush the pure doxycycline powder, maleic acid and glucose separately, pass through a No. 3 sieve (50 mesh), and weigh 50 kg of maleic acid. 45 kg of doxycycline and 5 kg of glucose can be prepared into soluble powder by mixing and packing.

[0008] For example, to produce 100 kg of compound doxycycline soluble powder, including 45% doxycycline and 10% nitazoxanide, first crush the pure doxycycline powder, maleic acid and glucose separately, and pass through a No. 3 sieve (50 Weigh 40 kg of maleic acid, 45 kg of doxycycline, and 5 kg of glucose, and mix them to make doxycycline soluble powder, then mix 10 kg of nitazoxanide pure powder and mix to make.

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Abstract

The present invention discloses a doxycycline soluble powder production method with characteristics of simple process, low cost and good product quality. The production method for producing the high quality doxycycline soluble powder through a simple method comprises: stirring and mixing pure doxycycline powder, maleic acid and glucose according to a certain ratio to prepare the doxycycline soluble powder, wherein the produced doxycycline soluble powder content can achieve 45%. The method has characteristics of less required auxiliary material, simple process, less required production equipment and low cost.

Description

technical field [0001] The invention belongs to a production method of veterinary medicine, in particular to a production method of a new generation of veterinary antibiotic doxycycline soluble powder. Background technique [0002] Doxycycline has broad-spectrum anti-anaerobic and antiprotozoal effects, and is mainly used clinically to prevent and treat infections caused by anaerobic bacteria, such as respiratory tract, digestive tract, abdominal cavity and pelvic pus infection, skin soft tissue, bone and bone joints, etc. Infection and endocarditis, sepsis and meningitis caused by Bacteroides fragilis are also widely used in the prevention and treatment of oral anaerobic infection. In 1987, WHO listed it as an essential drug for anti-infection. Through research and application in recent years, it has been found that it has many new uses, and now doxycycline is gradually being used in animal medicine. However, the original powder of doxycycline is a drug that is insoluble...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/65A61K47/26A61K47/12A61P33/02A61P31/04
Inventor 沈巍郝智慧
Owner QINGDAO BOITE BIOPHARM
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