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A kind of aminolevulinic acid hydrochloride liniment

A technology of aminolevulinic acid hydrochloride and powder, which is applied in the field of aminolevulinic acid hydrochloride liniment, can solve the problems of easy recurrence, pigmentation, poor drug safety, etc., and achieve the effect of simple preparation, short course of treatment and mild drug properties

Active Publication Date: 2015-09-23
XIANGYU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its purpose is to effectively treat and prevent acne, and overcome the defects of poor drug safety, pigmentation, and easy recurrence after drug withdrawal in the prior art.

Method used

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  • A kind of aminolevulinic acid hydrochloride liniment

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Comparison scheme
Effect test

Embodiment 1

[0023] A kind of aminolevulinic acid hydrochloride liniment, it is made up of powder and solvent two parts, and described powder is 354mg / bottle, and described solvent is 1.5ml / bottle, and the two parts are mixed together when using.

[0024] The powder is aminolevulinic acid hydrochloride;

[0025] The solvent is formed by mixing 602g of ethanol, 50g of sodium lauryl sulfate, 20g of polyethylene glycol 400, 45g of propylene glycol and 600g of pure water.

Embodiment 2

[0027] A kind of aminolevulinic acid hydrochloride liniment, it is made up of powder and solvent two parts, and described powder is 354mg / bottle, and described solvent is 1.5ml / bottle, and the two parts are mixed together when using.

[0028] Among them, ethanol, as a transdermal penetration enhancer and preservative, can increase drug penetration, thereby improving the skin's absorption of drugs, and has a certain antiseptic effect; polyethylene glycol 400 is a good cosolvent, and propylene glycol has moisturizing and antiseptic properties. The role; sodium lauryl sulfate as a surfactant, can promote the penetration of drugs.

[0029] The solvent is formed by mixing 602g of ethanol, 50g of sodium lauryl sulfate, 20g of polyethylene glycol 400, 45g of propylene glycol and 600g of pure water.

[0030] The powder is prepared by mixing aminolevulinic acid hydrochloride and active ingredients of traditional Chinese medicine according to the weight ratio of 3:2,

[0031] The prepa...

Embodiment 3

[0046] clinical information

[0047] 1. standard constrain:

[0048] 1) Age 18-45 years old, both male and female. 2) The onset begins at puberty, and it tends to occur on the face, upper chest and back where the sebaceous glands are developed, and the distribution is symmetrical. The skin lesions are follicular papules, pustules, nodules, cysts, comedones, and scars, with seborrhea and a chronic course. .3) The patient is able to complete the trial and voluntarily signs a written informed consent before the trial begins. 4) Those who have not used too much internal medicine or photosensitive drugs related to the disease within 30 days before treatment;

[0049] This trial was carried out in 4 clinical centers in China, and a total of 117 subjects were randomly enrolled. The median age of the subjects was 22.0 years old, 72 males and 45 females were randomly divided into group 1 with 37 people, group 2 with 40 people, and group 3 with 40 people. Each dose group was basic...

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Abstract

The invention relates to aminolevulinic acid hydrochloride liniment, which is composed of a solvent and powder, wherein the powder is prepared by mixing aminolevulinic acid hydrochloride with traditional Chinese medicine effective components according to the weight ratio of 3:2; when the aminolevulinic acid hydrochloride liniment disclosed by the invention is used, the solvent and the powder are mixed and dissolved together. The aminolevulinic acid hydrochloride liniment disclosed by the invention has the advantages of being simple and convenient for preparation, wide in medicine source, low in cost, high in acne curative rate and wide in application prospect.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to an aminolevulinic acid hydrochloride liniment. Background technique [0002] Acne, also known as "acne", is one of the common diseases in dermatology. Mainly occurs in adolescence, mostly on the face, whiteheads and blackheads at the beginning, small conical papules, and then develops into small red papules of various sizes, with pustules the size of rice grains to mung beans on the top . There may be mild itching, tenderness or tenderness. If the inflammation continues to increase, dark red nodules or cysts of different sizes can also be formed, sometimes ulcerated and pus-filled, which is called nodular cystic acne, which is a more serious type of acne. The etiology of the formation of moderate to severe or nodular acne mainly contains the following three aspects: (1) hyperfunction of the sebaceous glands. The development and secretion of s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/195A61K36/9064A61K47/10A61K47/34A61K47/20A61P17/10A61P17/00A61K35/64
Inventor 林凡友王丽娟
Owner XIANGYU PHARMA