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Ganoderma sinense polysaccharide dispersible tablet and preparation method thereof

A technology of Zizhi polysaccharide and dispersible tablets, applied in the field of medicine, can solve the problems such as the hardness and disintegration speed of Zizhi polysaccharide dispersible tablets cannot meet the requirements, and it has not been found to disclose the Zizhi polysaccharide dispersible tablets, which affects the quality and production efficiency of the dispersible tablets, and the like. Improve the taste of the solution, determine the therapeutic effect, and have good compression moldability

Active Publication Date: 2014-12-10
江西泽众制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, since Zizhi polysaccharide is easily soluble in water, phenomena such as moisture absorption and sticking are prone to occur during the preparation of Zizhi polysaccharide tablets, which affects the quality and production efficiency of dispersible tablets; in addition, the applicant found that when the main auxiliary materials such as fillers and When disintegrants and their dosages are improperly selected, the hardness and disintegration speed of Zizhi polysaccharide dispersible tablets cannot meet the requirements, and the stability of dispersible tablets is poor, which cannot meet the clinical treatment needs
At present, it has not been found that there is a Zizhi polysaccharide dispersible tablet disclosed in the prior art

Method used

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  • Ganoderma sinense polysaccharide dispersible tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Preparation of Zizhi polysaccharide powder:

[0035] Wash the Zizhi fruiting body and / or mycelium, drain, add water and decoct twice, decoct for 2 hours for the first time, filter the medicinal liquid with a 100-mesh filter cloth, add 5 times the amount of water to the dregs for the second Decoct for the second time for 2 hours, filter the medicinal liquid with a 100-mesh filter cloth, combine the medicinal liquid obtained from the second decoction, concentrate under reduced pressure to a clear paste with a relative density of 1.15 (heat measurement at 50°C), and add 95% Ethanol until the alcohol content reaches 62%, let it stand for 24 hours, take the supernatant to recover the ethanol until it has no alcohol smell, and the precipitate after recovering the ethanol is vacuum-dried at 60°C, and the moisture content of the dry extract is controlled within 3%. Put the paste into a high-efficiency pulverizer and pulverize it into fine powder, and pass through a 100-mesh sie...

Embodiment 2

[0037] prescription:

[0038] Zizhi polysaccharide powder

35% by weight

starch

30% by weight

microcrystalline cellulose

12% by weight

Crospovidone

5% by weight

4% starch slurry

15% by weight

aspartame

1.2% by weight

Sodium chloride

0.6% by weight

Micropowder silica gel

1.2% by weight

[0039] Preparation:

[0040] Weigh each raw material, mix Zizhi polysaccharide powder, starch, microcrystalline cellulose, crospovidone, aspartame and sodium chloride evenly; use 4% starch slurry to make a soft material from the mixture, and pass through a 18-mesh sieve to make a soft material. Granules; dry the wet granules at 50°C to make the water content of the granules 3.0%; pass the dried granules through a 16-mesh sieve for granulation; add micropowder silica gel to the granulated granules, mix well, and press into dispersible tablets. The dispersible tablet completely disintegrated within...

Embodiment 3

[0042] prescription:

[0043] Zizhi polysaccharide powder

23% by weight

Calcium sulfate

60% by weight

Sodium carboxymethyl starch

5.5% by weight

Crospovidone

1.5% by weight

30% ethanol

5% by weight

sodium saccharin

2.5% by weight

Talc powder

2.5% by weight

[0044] Preparation:

[0045] Weigh each raw material, mix the purple polysaccharide powder, calcium sulfate, sodium carboxymethyl starch, crospovidone, and sodium saccharin evenly; use 30% ethanol to make a soft material from the mixture, and granulate through a 16-mesh sieve; Dry at 70°C to make the water content of the granules 3.5%; pass the dried granules through a 16-mesh sieve for granulation; add talcum powder to the granulated granules, mix evenly, and press into dispersible tablets. The dispersible tablet completely disintegrated within 3 minutes and passed through the No. 2 sieve.

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Abstract

The invention provides a ganoderma sinense polysaccharide dispersible tablet and a preparation method thereof. The ganoderma sinense polysaccharide dispersible tablet is prepared from the following components in percentage by weight: 20-45% of ganoderma sinense polysaccharide powder, 40-65% of filler, 3-8% of a disintegrating agent, 5-20% of an adhesive, 1.5-3.5% of a corrigent and 0.5-3.0% of a lubricant. The ganoderma sinense polysaccharide dispersible tablet provided by the invention is good in dispersion uniformity and stability, and the technical problems of moisture absorption and sticking in the preparation process are solved. The prepared ganoderma sinense polysaccharide dispersible tablet can be used for treating neurasthenia, leucopenia and thrombopenia as well as symptoms of leucopenia caused by ionizing radiation, occupational hemopoiesis injury and radiotherapy and chemotherapy of tumor patients and the like, and is non-irritant to human body and few in adverse effects.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a dispersible tablet of Zizhi polysaccharide and a preparation method thereof. Background technique [0002] Leukopenia refers to the absolute count of peripheral blood white blood cells continuously lower than 4.0×10 9 / L. Neutrophils are the main component of white blood cells, so neutropenia often leads to leukopenia. The disease can be divided into mild, moderate and severe leukopenia according to the degree of neutropenia. Generally, patients with mild reduction do not have special symptoms clinically, and mostly manifest as symptoms of the primary disease. Moderate and severe decreasers are prone to infection and non-specific symptoms such as fatigue, weakness, dizziness, and loss of appetite. Platelet disorders are caused by poor hemostatic clot formation and bleeding due to decreased number (thrombocytopenia) or decreased function (thrombocytopenia) of platelets. The platelet...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/715A61K47/38A61K47/18A61P25/00A61P7/00A61P7/04A61J3/00
Inventor 于新江
Owner 江西泽众制药股份有限公司
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