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Application of butterflybush flower and extract thereof to preparation of medicament

A technology of extract and Mimena japonica, which is applied in a new application field in medicine, can solve the problem of no literature report on the treatment of heart disease by Mimeng flower.

Active Publication Date: 2014-07-16
YUNNAN SUNSAIL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Prior to this, there were many patent applications and literature reports on the application of Budhimonica in the preparation of ophthalmology and liver therapeutic drugs, but there is no literature report in the treatment of heart disease.

Method used

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  • Application of butterflybush flower and extract thereof to preparation of medicament
  • Application of butterflybush flower and extract thereof to preparation of medicament
  • Application of butterflybush flower and extract thereof to preparation of medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0131] Embodiment 1: Mimenghua tablet

[0132] Recipe: 1000 parts of Budisma, 3 parts of starch, 20 parts of lactose, 15 parts of sodium carboxymethyl starch, 4 parts of talcum powder.

[0133] Preparation method: Take 800 copies of Budhisattva, extract twice with drinking water according to the decoction method, each time for 1 hour, combine the decoction (or take Budhisattva, crush it into a coarse powder, and use different concentrations of aqueous ethanol at 40°C Soak twice, each time for 6-8 hours, combine the infusions, recover ethanol), concentrate the decoction to form a thick paste, dry at 55°C-65°C, and grind into fine powder for later use. Take another 200 parts of Budisma japonica, directly crush it into fine powder, mix with the above-mentioned Budhistia japonica extract powder, lactose, sodium carboxymethyl starch, use starch slurry as binder, make granules, dry, add talcum powder Mix well and press into tablets.

Embodiment 2

[0134] Embodiment 2: Mimenghua capsules

[0135] Recipe: 1000 parts of Mimenghua, 100 parts of starch.

[0136] Preparation method: Take 800 copies of Budhimonica, extract twice with drinking water or (water-containing ethanol) according to the decoction method, each time for 1 hour, combine the decoction (or take Budmija, crush it into coarse powder, and use different concentrations of Soak twice in water-containing ethanol, 6-8 hours each time, combine the infusions, recover ethanol), concentrate the decoction to form a thick paste, dry at 55°C-65°C, and grind into fine powder for later use. Another 200 parts of Budisma japonica were taken, directly crushed into fine powder, mixed with the above-mentioned Budisma japonica extract fine powder and starch, and then packed into capsules.

Embodiment 3

[0137] Embodiment 3: Mimenghua capsules

[0138] Recipe: 1000 parts of Mimenghua, 100 parts of starch.

[0139] Preparation method: Take 700 parts of Mimenghua, crush it into a coarse powder, extract it twice with ethyl acetate at room temperature, the first time is 48 hours, and the second time is 40 hours, combine the infusions, recover ethyl acetate, and extract for later use. Another 300 parts of Budisma japonica were taken, directly crushed into fine powder, mixed evenly with the above-mentioned Budhistia japonica extract, dried at 60°C-70°C, crushed into fine powder, mixed with starch, and packed into capsules.

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Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to new application of a natural plant medicinal herb and / or an extract thereof to preparation of a medicament for treating heart disease. The invention relates to application of butterflybush flower and / or an extract thereof to preparation of the medicament for treating heart disease. The butterflybush flower is buds, inflorescence or complete plant of loganiaceae plant butterflybush flower; the extract is obtained by the steps of crushing butterflybush flower and carrying out leaching or heating reflux or supercritical extraction at room temperature; the used solvent in extraction is a miscible liquid mixture of water and ethanol in a random ratio or a miscible liquid mixture of ethyl ether, petroleum ether, chloroform, ethyl acetate and other organic solvents in a random ratio or liquid state CO2. The butterflybush flower and / or extract thereof can separately serve as a main active ingredient to be prepared into a pharmaceutical preparation, and can also serve as the main active ingredient together with other components to be prepared into the pharmaceutical preparation.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a new application of natural plant medicinal materials and / or extracts thereof in the preparation of medicines for treating heart disease. technical background [0002] Since the 1990s, heart disease has gradually become the main cause of death of urban and rural residents in my country due to its wide range of incidence, high incidence frequency and great harm. Currently it accounts for 35% of the total death toll and is the No. A big killer. At present, heart disease is mostly treated with surgery and western medicine. However, due to the large side effects of western medicine treatment of heart disease, it often causes many adverse reactions, resulting in great damage to the patient's liver, kidney, intestines, stomach and other organs. In this case, people try to Looking for a more suitable method, and Chinese medicine is its own advantage in...

Claims

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Application Information

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IPC IPC(8): A61K36/56A61P9/10A61P9/00A61P29/00A61P35/00A61K133/00
CPCA61K36/56A61K2236/33A61K2236/333A61K2236/35A61K2236/37A61K2236/53
Inventor 温先敏
Owner YUNNAN SUNSAIL PHARMA
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