Application of thiol-polyethylene glycol in preparation of water-soluble gold nano-clusters

A thiol polyethylene glycol, gold nanocluster technology, applied in the field of nanomaterials, can solve the problems of unstable gold nanoclusters, poor modifiability, complex synthesis, etc., and achieve the effects of improving stability, good stability and simple synthesis

Inactive Publication Date: 2014-07-16
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Purpose of the invention: In order to overcome problems such as instability, poor modifiability, poor targeting, and complex synthesis of gold nanoclusters prepa

Method used

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  • Application of thiol-polyethylene glycol in preparation of water-soluble gold nano-clusters
  • Application of thiol-polyethylene glycol in preparation of water-soluble gold nano-clusters
  • Application of thiol-polyethylene glycol in preparation of water-soluble gold nano-clusters

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Experimental program
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Effect test

Embodiment 1

[0028] The preparation method of water-soluble gold nanocluster comprises the following steps:

[0029] (1) Chlorauric acid and reducing agent were reacted in the dark for 3 hours at room temperature, and a yellow gold nanocluster precursor solution with blue-green fluorescence but unstable was obtained. The TEM results are shown in figure 1 .

[0030] (2) reacting the gold nanocluster precursor and mercapto polyethylene glycol at room temperature in the dark for 8 hours to obtain a light yellow gold nanocluster solution that emits orange-yellow fluorescence;

[0031] (3) Use a dialysis bag with a molecular weight of 2000 to dialyze the gold nanocluster solution to obtain a pure orange-yellow fluorescent colorless gold nanocluster solution. The TEM results are shown in figure 2 .

[0032] Wherein, the reducing agent is histidine, and the mercapto polyethylene glycol is HS-C 11 -EG 6 ; The molar ratio of chloroauric acid, reducing agent and mercapto polyethylene glycol is ...

Embodiment 2

[0036] The preparation method of water-soluble gold nanocluster comprises the following steps:

[0037] (1) Chlorauric acid and reducing agent were mixed and reacted at room temperature for 5 minutes to obtain a brown precursor solution with blue fluorescence but unstable;

[0038] (2) react the precursor solution with mercapto polyethylene glycol at room temperature in the dark for 3 hours to obtain a light yellow gold nanocluster solution that emits purple fluorescence;

[0039] (3) Dialyzing the gold nanocluster solution with a dialysis bag with a molecular weight of 2000 to obtain a pure orange-yellow fluorescent colorless gold nanocluster solution.

[0040] Wherein, the reducing agent is tyrosine, and the mercaptopolyethylene glycol is HS-C with a substance ratio of 4:1 11 -EG 6 and (11-mercaptoundecyl)hexa(ethylene glycol)methyleneoxy carboxyl (HS-C 11 -EG 6 -OCH 2 -COOH). The molar ratio of chloroauric acid, reducing agent and mercapto polyethylene glycol is 1:10:...

Embodiment 3

[0044] The preparation method of water-soluble gold nanocluster comprises the following steps:

[0045] (1) Chlorauric acid and reducing agent were reacted in the dark for 5 hours at room temperature to obtain a yellow gold nanocluster precursor solution with blue-green fluorescence but unstable;

[0046] (2) The gold nanocluster precursor reacted with mercaptopolyethylene glycol at room temperature in the dark for 12 hours to obtain a light yellow gold nanocluster solution with orange-yellow fluorescence

[0047] (3) Dialyzing the gold nanocluster solution with a dialysis bag with a molecular weight of 2000 to obtain a pure orange-yellow fluorescent colorless gold nanocluster solution.

[0048] Wherein, the reducing agent is histidine, and the mercaptopolyethylene glycol is HS-C with a substance ratio of 4:1 11 -EG 6 and (11-mercaptoundecyl)hexa(ethylene glycol)amino (HS-C 11 -EG 6 -NH 2 ). The molar ratio of chloroauric acid, reducing agent and mercapto polyethylene gl...

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Abstract

The invention provides application of thiol-polyethylene glycol in preparation of water-soluble gold nano-clusters. The thiol-polyethylene glycol is shown as the following formula (I): HS-(CH2)m-(OCH2CH2)<n>-X. The water-soluble gold nano-clusters prepared by utilizing the thiol-polyethylene glycol have the advantages of being high in purity (being capable of stably existing in hyperpure water, high in stability (being stable in different pH values and different buffering solution systems), high in water solubility, supportive of surface chemical modifying, supportive of targeting, simple to synthesize and the like.

Description

technical field [0001] The invention belongs to the technical field of nanometer materials, and in particular relates to the application of mercapto polyethylene glycol in the preparation of water-soluble gold nanoclusters. Background technique [0002] Metal nanoclusters generally consist of a few to a hundred atoms, which are a new type of nanomaterials and have attracted widespread interest in recent years. The diameter of typical gold nanoclusters is below 4nm, and its properties are between single atoms and slightly larger nanoparticles. Because the size of nanoclusters is close to the Fermi wavelength of electrons, the density of the continuum is divided into discrete energy levels, which makes the nanoclusters have different optical, electrical, and chemical properties among the nanoparticles. The main difference is that the nanoclusters have strong fluorescence, and the stability of the fluorescence is good, the Stokes shift is large, and the emissivity is high. ...

Claims

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Application Information

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IPC IPC(8): B22F9/24B82Y40/00
Inventor 吴富根张晓东王宏银陈战
Owner SOUTHEAST UNIV
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