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Schlemm canal expandable stent and combination bodies thereof

A technology of Schlemm's canal and assembly, applied in the direction of stents, dilators, and other medical devices, to achieve the effects of promoting the drainage of aqueous humor, reducing serious damage, and reducing restenosis

Active Publication Date: 2014-07-23
BEIJING TONGREN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] Most of the problems with existing glaucoma treatment devices and treatments are due to the drainage of aqueous humor from the interior of the eye to the surface of the eye

Method used

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  • Schlemm canal expandable stent and combination bodies thereof
  • Schlemm canal expandable stent and combination bodies thereof
  • Schlemm canal expandable stent and combination bodies thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Such as figure 1 As shown, a Schlemm canal (Schlemm) expansion stent, the expansion stent is a cylindrical hollow shell 1, the shell is provided with a channel 2, and the outer diameter of the shell is 0.2MM to 0.5 MM, the length of the shell is 0.5MM to 4MM, the thickness of the shell is 0.04MM to 0.06MM, and the shell can also be a drum-shaped surface.

[0039] The shell is a cylindrical surface or a drum-shaped surface formed by a curve formed by the metal wire through repeated circumferential bending and axial refolding, and the curve forming the cylindrical surface or the drum-shaped surface is a regular A helical ring 3 and a reverse helical ring 4 are formed, the linear length of the forward helical ring and the linear length of the reverse helical ring are greater than the circumference of the cylinder and less than twice the circumference of the cylinder, each adjacent One end of the normal helical ring and the other end of the reverse helical ring form a row ...

Embodiment 2

[0044] see figure 2 with image 3 , the housing of another structure of the present invention is a mesh structure 8, the mesh structure includes a plurality of corrugated ring-shaped support structure units 9, the ring-shaped support structure units are arranged in order left and right, each row of ring-shaped support structures The crests corresponding to the units are close to each other, and the troughs corresponding to the ring-shaped support structure units in each row are far away from each other, and the adjacent crests are connected by rods 10, and the shape of the rods is C-shaped or W-shaped.

[0045] In Embodiment 1 and Embodiment 2, the shell is coated with a polymer nanocoating composed of a tissue growth inhibitor.

Embodiment 3

[0047] A Schlemm's canal (Schlemm) expansion stent, such as Figure 4 As shown, the expansion stent is a cylindrical hollow shell, and the cylindrical surface is formed by an alloy wire 11 arc bent 360 degrees and then bent back 11-1 arc 360 degrees to form a continuous circular curve Composed of rings 12, this structure has higher strength than the cylindrical surface formed by single-wire circular arc winding; at least one end of the alloy wire is an enlarged end 11-2 with a diameter larger than the diameter of the alloy wire, and this enlarged end can be easily A rope is fixed, and the rope is used to facilitate the removal of the stent; in order to make the stent have the function of delivering medicine and releasing slowly, the surface of the alloy wire is coated with a coating with a thickness of 10 microns to 20 microns, and the coating includes adhesive The bottom layer and the drug layer are used to bond the drug to the alloy wire. Usually, the bottom layer is made of...

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Abstract

The invention relates to a Schlemm canal expandable stent and combination bodies of the Schlemm canal expandable stent. The expandable stent is a hollow shell with a cylindrical surface. The cylindrical surface is composed of round continuous curved rings formed in the manner that an alloy wire is bent and then bent back. The surface of the alloy wire is coated with a coating with the thickness ranging from 10 microns to 50 microns. The coating comprises an adhesive bottom layer and a drug layer. By means of the Schlemm canal expandable stent, damage of the stent wall to the wall of a Schlemm canal can be reduced, the occurrence rate of restenosis and proliferation of a Schlemm canal cavity can be lowered, and excellent flexibility is achieved. The Schlemm canal expandable stent can enable drugs to be effectively and permanently released at a narrow diseased region, reduce serious damage of the stent wall to the wall of the Schlemm canal and ensure accurate local dosing to a target diseased point, thereby being capable of more effectively lowering the occurrence rate of restenosis of the Schlemm canal and achieving the purposes of promoting discharging of aqueous humo, reducing intraocular pressure and treating glaucoma.

Description

technical field [0001] The invention relates to an ophthalmic stent, in particular to a Schlemm canal (Schlemm) expansion stent for placing in the intraocular Schlemm canal (Schlemm) and a combination thereof. Background technique [0002] Glaucoma is a serious public health disease. More specifically, glaucoma is an optic neuropathy (disease of the optic nerve), which is usually caused by poor drainage of aqueous humor in the eye, resulting in increased intraocular pressure. Increased pressure in the eye damages the optic nerve and narrows the field of vision. When the patient has persistent high eye pressure, it can lead to blindness in the patient. [0003] The eye is a hollow structure that contains a clear fluid called "aqueous humor". Aqueous humor is formed in the posterior chamber of the eye via the ciliary body at a rate of approximately 2.5 microliters per minute. The fluid produced at a fairly constant velocity then passes around the lens and through the pupil ...

Claims

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Application Information

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IPC IPC(8): A61F9/007A61F2/88A61F2/90A61M29/00A61M31/00
Inventor 王宁利牟大鹏王怀洲
Owner BEIJING TONGREN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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