an isotope 13 separation method of c

Abstract

The invention provides a separation method for carbon-13 isotope. The method includes following steps: firstly feeding gas into a chromatographic column of each stage separation system for carrying out a heating and activating process to remove water and air impurities out from the chromatographic column; feeding CO raw material gas into a first stage separation system at a low temperature of liquid nitrogen; carrying out a chromatogram separating process to the CO raw material with one part being discharged as depleted gas and the other part, which is driven by a carrying gas, being fed into a second stage separating system as a concentrated sample; carrying out the chromatogram separating process to the concentrated sample with one part being fed back to first stage separation system as the depleted gas and the other part being fed into a third stage separating system as a concentrated sample; carrying out the chromatogram separating process to the concentrated sample with one part being fed back to the second stage separation system as the depleted gas and the other part being fed into a fourth stage separating system as a concentrated sample; and carrying out the chromatogram separating process to the concentrated sample with one part being fed back to the third stage separation system as the depleted gas and the other part being a CO-13 production gas which is 99% in abundance of carbon-13. The separation method is simple in process, low in operating cost, high in safety and flexibility and strong in universality.

Description

technical field [0001] The present invention belongs to stable isotope 13 The technical field of C separation and preparation, specifically relates to a method of using CO to prepare chromatographic separation of isotopes 13 C's method. Background technique [0002] stable isotope 13 C is widely used in biomedicine, pharmacology, nutrition, earth science, agriculture and organic chemistry, environmental science, security technology and other fields because of its non-radioactive, non-toxic and stable properties, especially in recent years. 13 C-urea breath test ( 13 C-Urea Breath Test, 13 C-UBT) is widely used in clinical diagnosis, gradually replacing radioactive 14 C, become an internationally recognized "gold standard". Although 13 The clinical application of C-urea breath test has been approved by the State Food and Drug Administration of China, but these drugs are very expensive, especially in the domestic blank, and all rely on imports, which seriously affects t...

AI Technical Summary

Problems solved by technology

[0004] In my country, the Shanghai Research Institute of Chemical Industry has been engaged in the separation of light isotopes for many years, and is conducting the separation of CO low temperature distillation 13 Although the research on C has progressed (patents CN101745315A, CN102430337A, CN102380315A), compared to the selling price of Americans, it is unlikely that the cost will be lower than that of Americans.

Especially in today's rising energy prices, the cost of cryogenic distillation will inevitably remain high, and even continue to rise

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