3results about How to "Reduce holdup" patented technology

This utility model discloses a novel sealing structure for a filter unit of a PTA pressure filter, including a filter tank and a filter unit installed inside it. The filter unit includes a filter base, a sealing ring, fixing bolts, a non-asbestos gasket, and a ring gasket. The filter base is installed inside the filter tank, and has a through-hole at its center for allowing filtered liquid to flow out. The sealing ring is embedded in the through-hole of the filter base. The filter tank has a liquid outlet at its center that communicates with the through-hole. A non-asbestos gasket is pressed between the bottom surface of the filter base and the bottom upper surface of the filter tank. The filter base, filter tank, and non-asbestos gasket are fastened together by several fixing bolts. The non-asbestos gasket has a liquid passage hole at its center that corresponds to the through-hole and the liquid outlet, and the wall of the liquid passage hole is covered with a ring gasket. This utility model improves the structure of the sealing gasket to prevent liquid from eroding it.

The invention discloses a bispecific antibody-UC-MSCs preparation for targeting prostate diseases as well as preparation and application of the bispecific antibody-UC-MSCs preparation. The preparation comprises a bispecific antibody BsAb-1 and human umbilical cord mesenchymal stem cells (UC-MSCs), the BsAb-1 is formed by connecting an anti-CD105 single-domain antibody, an anti-PSCA single-domain antibody and a flexible peptide linker in series, wherein the amino acid sequence of the BsAb-1 is as shown in SEQ ID NO: 4. According to the preparation, the UC-MSCs are delivered to a prostate focus through the targeting bridge effect of BsAb-1, the focus enrichment amount within 72 hours is increased by 6.3 times compared with that of pure UC-MSCs, and meanwhile retention of non-target organs such as the liver and the spleen is reduced. The preparation can effectively relieve inflammatory response and fibrosis of chronic prostatitis, and the curative effect of the preparation is remarkably superior to that of pure UC-MSCs treatment. Precise targeted treatment of prostate diseases is achieved, the curative effect is remarkably better than that of a traditional stem cell therapy method, and high clinical application value is achieved.

The present application relates to the technical field of petroleum chemical industry, in particular to a kind of heterogeneous synthesis device and method of cyclohexanone oxime.The synthesis device of the present application includes vortex reactor, rotating rod and stirrer;By inserting rotating rod in vortex reactor, annular reaction zone with gap size of 0.5mm-5mm is formed, under the dual action of microscale effect and rotating field, mass transfer resistance is reduced, reaction liquid and catalyst particles are fully contacted, and reaction liquid can be broken into smaller droplets under the shear force provided by rotating field, so that the contact area of oil-water two phases is increased, fully emulsified, uniformly mixed, and the flow distribution of catalyst particles is more uniform, the efficiency of catalytic reaction is improved;At the same time, the concentration distribution of hydrogen peroxide in annular reaction zone is controlled by cooperating with multi-stage feeding mode of hydrogen peroxide, so that the concentration of hydrogen peroxide is matched with the rate of catalytic reaction, thereby improving the utilization rate of hydrogen peroxide, and realizing the efficient synthesis of cyclohexanone oxime.