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Preparation method of aptamer-induced Ag2S quantum dots

An aptamer and quantum dot technology, applied in the field of material chemistry, can solve the problems of poor product biocompatibility, reduced product quantum yield, and harsh preparation conditions, and achieve the effects of environmental friendliness, simple operation, and mild reaction conditions

Inactive Publication Date: 2014-08-20
NANJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Among them, the co-precipitation method is mostly carried out in organic solvents, and there are disadvantages such as harsh preparation conditions and toxic reagents.
Moreover, the products prepared in organic solvents have poor biocompatibility. If they are to be further applied in the field of biomedicine, their water solubility must be improved through subsequent steps such as phase transfer and purification, but the quantum yield of the products will also be reduced accordingly.

Method used

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  • Preparation method of aptamer-induced Ag2S quantum dots
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  • Preparation method of aptamer-induced Ag2S quantum dots

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Embodiment 1

[0025] The aptamer S2.2 whose end was modified with 6 cytosine Cs was dispersed in deionized water to obtain an aqueous aptamer solution with a concentration of 5 μmol / L. Add 1 mol / L AgNO to the solution 3 10 μL aqueous solution, stirred at room temperature for 1-5 min, then added 1 mol / L Na 2 S aqueous solution 2 μL, stirred at room temperature for 1-10 min, and the product was dried to obtain Ag 2 S quantum dots, the average particle size is about 2 nm.

Embodiment 2

[0027] The aptamer S2.2, whose end was modified with 12 cytosine Cs, was dispersed in deionized water to obtain an aqueous aptamer solution with a concentration of 10 μmol / L. Add 1 mol / L AgNO to the solution 3 20 μL aqueous solution, stirred at room temperature for 1-5 min, then added 1 mol / L Na 2 S aqueous solution 5 μL, stirred at room temperature for 1-10 min, and the product was dried to obtain Ag 2 S quantum dots, the average particle size is about 2 nm.

Embodiment 3

[0029] The aptamer S2.2, whose end was modified with 18 cytosine Cs, was dispersed in deionized water to obtain an aqueous aptamer solution with a concentration of 20 μmol / L. Add 1 mol / L AgNO to the solution 3 40 μL aqueous solution, stirred at room temperature for 1-5 min, then added 1 mol / L Na 2 S aqueous solution 5 μL, stirred at room temperature for 1-10 min, and the product was dried to obtain Ag 2 S quantum dots, the average particle size is about 2 nm.

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Abstract

The invention discloses a preparation method of aptamer-induced Ag2S quantum dots. The method comprises the following steps: firstly dispersing aptamers with terminals modified with cytosine C in deionized water, then adding an AgNO3 water solution, performing magnetic stirring at room temperature, slowly dropping a Na2S water solution into a mixture and drying a product so as to obtain the Ag2S quantum dots. According to the method disclosed by the invention, the aptamers are taken as inducers in a water phase, the reaction is performed at room temperature, the fixed-direction growth of the Ag2S quantum dots is realized, then ultra-fine nano-particles with good dispersion are obtained and the prepared Ag2S quantum dots can be used as a novel near-infrared region fluorescent material and further have specific identification function against target molecules. The preparation method disclosed by the invention is simple and economic and suitable for large-scale production.

Description

technical field [0001] The invention relates to a near-infrared Ag 2 The preparation method of S quantum dots, especially involving an aptamer-induced Ag 2 The preparation method of S quantum dots, the nano material prepared by the method has unique optical properties, is a new type of fluorescent material in the near-infrared region, can be used in the fields of immune sensors, DNA probes and imaging, and belongs to the field of material chemistry. Background technique [0002] Ag 2 S is an advanced functional material with a variety of unique properties, such as high dark ionic and electronic conductivity, photoconductivity and photographic sensitivity over a wide wavelength range, in addition, Ag 2 S also has photovoltaic and photochromic effects. In the early days, it was used as a solar selective coating in photoconductive and photovoltaic cells, ion selective electrodes and membranes, IR detectors, laser recording media and other fields. In recent years, with the A...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01G5/00C09K11/58
Inventor 蔡称心印亚静高静文吴萍张卉
Owner NANJING NORMAL UNIVERSITY
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