Feed additive capable of replacing antibiotics as well as preparation method and application of feed additive

A feed additive, a technology for replacing antibiotics, applied in the application, animal feed, animal feed and other directions, can solve the problems of low volatile oil content, high extraction cost, difficult to apply in large quantities, etc., and achieves high extraction rate, simple method and process, and good activity. Effect

Active Publication Date: 2014-08-27
湖南东方红药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the low content of volatile oil in general traditional Chinese medicine and the high cost of extraction, it is difficult to apply in large quantities
Therefore, natural and easily obtained resour

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0031] Example 1

[0032] A feed additive that can replace antibiotics, its preparation method is as follows:

[0033] (1) Take 200g camphor leaves, 100g eucalyptus leaves, 100g pine needles, 50g arborvitae leaves and 50g mugwort leaves and mix them as a raw material mixture, and perform supercritical carbon dioxide extraction to obtain 35g of mixture extract and residue; the conditions for supercritical carbon dioxide extraction are: Extraction pressure 15MPa, extraction time 1h, extraction temperature 35℃;

[0034] (2) Add 350g of a 10% aqueous solution of β-cyclodextrin to the mixture extract, grind for 0.5h, remove the water by suction and dry in vacuo to obtain 69g of the first product;

[0035] (3) Add the residue described in step (1) to 2.5 kg of 85% ethanol aqueous solution, extract at 60° C. for 2 hours, filter, concentrate the filtrate under reduced pressure, and dry in vacuo to obtain 80 g of the second product;

[0036] (4) The above-mentioned products of the first type an...

Example Embodiment

[0037] Example 2

[0038] A feed additive that can replace antibiotics, its preparation method is as follows:

[0039] (1) Take 500g camphor leaves, 300g eucalyptus leaves, 300g pine needles, 200g arborvitae leaves and 200g mugwort leaves and mix them as raw material mixtures, and perform supercritical carbon dioxide extraction to obtain 130g mixture extracts and residues; the supercritical carbon dioxide extraction conditions are: The extraction pressure is 30MPa, the extraction time is 3h, and the extraction temperature is 65℃;

[0040] (2) Add 3.9kg of 30% β-cyclodextrin aqueous solution to the mixture extract, grind for 2h, remove the water by suction and vacuum dry to obtain 1.29kg of the first product;

[0041] (3) Add the residue described in step (1) to 22.5kg of 70% ethanol aqueous solution, extract at 70°C for 1 hour, filter, concentrate the filtrate under reduced pressure, and dry in vacuo to obtain 220g of the second product;

[0042] (4) The above-mentioned products of the...

Example Embodiment

[0043] Example 3

[0044] A feed additive that can replace antibiotics, its preparation method is as follows:

[0045] (1) Take 300g camphor leaves, 200g eucalyptus leaves, 200g pine needles, 100g arborvitae leaves and 100g mugwort leaves and mix them as the raw material mixture, and perform supercritical carbon dioxide extraction to obtain 68g of the mixture extract and residue; the conditions for supercritical carbon dioxide extraction are: Extraction pressure 20MPa, extraction time 2h, extraction temperature 45℃;

[0046] (2) Add 1.36 kg of 20% β-cyclodextrin aqueous solution to the mixture extract, grind for 1 hour, remove water by suction, and dry in vacuo to obtain 338 g of the first product;

[0047] (3) Add 9kg of 60% ethanol aqueous solution to the residue described in step (1), extract at 85°C for 3h, filter, concentrate the filtrate under reduced pressure, and vacuum dry to obtain 105g of the second product;

[0048] (4) The above-mentioned products of the first type and the...

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Abstract

The invention belongs to the field of an agricultural feed additive, and discloses a feed additive capable of replacing antibiotics as well as a preparation method and the application of the feed additive. The feed additive comprises the following raw material extracts in parts by weight: 20-50 parts of cinnamomum camphora leaves, 10-30 parts of eucalyptus leaves, 10-30 parts of pine needles, 5-20 parts of cacumen biotae and 5-20 parts of folium artemisiae argyi. The preparation method comprises the steps of (1) carrying out supercritical carbon dioxide extraction on the raw material mixture to obtain an extract and residues; (2) mixing the extract with beta-cyclodextrin water solution, grinding, carrying out suction filtration, and carrying out vacuum drying to obtain a first product; (3) extracting the residues by ethanol water solution, filtering, carrying out vacuum concentration, and carrying out vacuum drying to obtain a second product; and (4) evenly mixing the two products to obtain the feed additive. The feed additive can be used for replacing the antibiotics to be added into the animal feed; the add amount of the feed additive is 0.01-0.5%; the feed additive can be used for improving the disease resistance of livestock and poultry and controlling bacteria infection diseases of livestock and poultry.

Description

technical field [0001] The invention belongs to the field of agricultural feed additives, and in particular relates to a feed additive that can replace antibiotics, a preparation method and application thereof. Background technique [0002] The abuse of antibiotics in livestock and poultry farming has become a common phenomenon. The use of a large number of antibiotics not only pollutes the environment, but also induces bacterial resistance, forming a safety hazard. Finding alternatives to antibiotics has become a research hotspot today. [0003] Many Chinese herbal medicines are antibacterial and antibacterial, and are alternative resources for antibiotics. CN101352202A discloses a feed additive that can replace antibiotics in chicken rations, which is composed of extracts of Pulsatilla pulsatillae, purslane, Folium oleracea and folium folium. CN102178066A discloses another compound polysaccharide feed additive that can replace antibiotics in chicken rations, which consi...

Claims

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Application Information

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IPC IPC(8): A23K1/14A23K1/16A23K1/18C11B9/02A23K10/30A23K50/75
CPCY02A40/70
Inventor 叶勇李月
Owner 湖南东方红药业有限公司
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