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A kind of anticoagulant pharmaceutical composition and its application

A composition and anti-coagulation technology, applied in the field of medicine, can solve the problems of anti-coagulation or anti-thrombosis without rafenolactone, and achieve remarkable effects and prevent stroke or other thrombotic diseases

Active Publication Date: 2016-03-30
NANTONG FINC PHARMA CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

By searching the literature at home and abroad, there is no literature report on anticoagulant or antithrombotic of rafenolactone

Method used

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  • A kind of anticoagulant pharmaceutical composition and its application
  • A kind of anticoagulant pharmaceutical composition and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Example 1: Effect test of rafenolactone on mouse bleeding and coagulation time

[0014] 36 SPF level healthy Kunming mice, half male and half male, body weight (20 2) g. 36 mice were randomly divided into three groups: normal saline group (10ml / kg), high-dose rafenolactone group (15mg / kg), low-dose group (5mg / kg), 12 in each group. 40 minutes after the intraperitoneal injection of the mouse, use scissors to cut off the tail tip of the mouse at 0.5 cm, and use a stopwatch to time when the bleeding begins, and stick the bleeding at the broken end with filter paper every 30 seconds until the red blood is completely gone on the filter paper. is the bleeding time of the mouse. The longest bleeding time was observed for 60 minutes, and if the blood was still bleeding after 60 minutes, it was calculated as 60 minutes.

[0015] One hour after the administration, the mouse's eyeball was picked to collect blood, and the coagulation time was measured by the glass slide method;...

Embodiment 2

[0020] Example 2: Effect test of rafenolactone on thrombus formation in rat common arteries

[0021] 30 SD rats, half male and half male, body weight (300 20) g. SD rats were randomly divided into the following three groups: normal saline group (5ml / kg), high-dose rafenolactone group (10mg / kg), low-dose group (3.3mg / kg), 10 rats in each group. After anesthetized by intraperitoneal injection of 10% chloral hydrate solution 4.5ml / kg, the rats were fixed on a small animal dissecting board, the left external jugular vein and the right common carotid artery were bluntly separated, and corresponding doses of the recipients were injected from the left external jugular vein. After 5 minutes of drug testing, a YLS-14B thrombogenesis instrument was used to induce thrombus formation in the right common carotid artery of rats by electrical stimulation (current 1mA, stimulation time 5min), observe the thrombus obstruction of the right common carotid artery, and print out relevant data. ...

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PUM

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Abstract

The invention discloses an anticoagulation pharmaceutical composition. The pharmaceutical composition is prepared from active ingredients and auxiliary materials, wherein the active ingredients include triptophenolide. The pharmaceutical composition is remarkable in anticoagulation effect, and can be used for preventing and treating intravascular embolisms and diseases induced by the embolisms and preventing strokes or other thrombotic diseases.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an anticoagulant pharmaceutical composition and its application. Background technique [0002] The balance between coagulation and anticoagulation is one of the important defense functions of the body. When the body causes bleeding due to some reason, the extrinsic blood coagulation system and the endogenous blood coagulation system can be activated successively to produce hemostasis. While activating the coagulation system, the anticoagulant system and fibrinolytic system are also activated. The activation of the anticoagulant system can prevent the spread of the coagulation process; the activation of the fibrinolytic system is conducive to the recanalization of local blood flow. It can be seen that the body's coagulation, anticoagulation, and fibrinolytic systems maintain a dynamic balance to ensure normal blood circulation. In addition, platelets and vascular e...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/585A61P7/02A61P9/10
Inventor 戎利军张纪红
Owner NANTONG FINC PHARMA CHEM