Preparation method of concentrated six-taste glutinous rehmannia capsule

A technology for Liuwei Dihuang and capsules, which is applied in the field of preparation of concentrated Liuwei Dihuang capsules, can solve the problems of easily mixing impurities, reducing bioavailability, poor preparation stability and the like

Inactive Publication Date: 2014-08-27
余中华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] 1. Poor formulation stability
The components of peony bark are easily sublimated and lost
2. Low bioavailability
Not properly processing, extracting, purifying, etc. according to the characteristics of each raw drug, so that the efficacy of each raw drug is not fully utilized, resulting in low bioavailability
3. Low dissolution rate and long extraction time
4. Low extraction rate and transfer rate of active ingredients
Compared with the extraction and preparation technology of Pharmacopoeia, this preparation method has been greatly improved, but there are still some deficiencies, such as the low extraction rate of Moutan Cortex steam distillation, which is easily mixed with impurities; The interaction between the components of the medicinal flavor is complex, which affects the full extraction of the active ingredients; moreover, the extraction conditions are the most suitable, and the combined extraction is difficult to make the most suitable screening for the individual extraction conditions of each medicinal flavor
At the same time, the preparation method does not extract and refine Rehmannia glutinosa, and cannot effectively enrich the medicinal ingredients, thereby reducing the bioavailability, etc.

Method used

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  • Preparation method of concentrated six-taste glutinous rehmannia capsule
  • Preparation method of concentrated six-taste glutinous rehmannia capsule
  • Preparation method of concentrated six-taste glutinous rehmannia capsule

Examples

Experimental program
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Effect test

Embodiment 1

[0119] Rehmannia glutinosa 100 parts, wine cornus 45 parts, moutan bark 30 parts, yam 40 parts, Poria cocos 30 parts, Alisma 25 parts;

[0120] (1) Take raw material Rehmannia glutinosa, wine cornus, Cortex Moutan, Chinese yam, Poria cocos, Alisma, by weight proportioning, for subsequent use;

[0121] (2) Take Moutan cortex and grind it into granules, and put it in CO 2 The volatile oil is extracted in a supercritical extraction kettle, where the pressure is 30Mpa, the temperature of the extraction kettle is 45°C, and the CO 2 The flow rate is 15L / h, the extraction time is 1.0 hour, and the volatile oil (I) of Cortex Moutan is collected for subsequent use; the remaining medicinal residues are reflux extracted twice with 70% ethanol with a concentration of 5 times the amount, each time for 1 hour, and the reflux liquid is collected and filtered. Recover ethanol until there is no alcohol smell, add hot water twice the amount of the original medicinal materials, slowly add stirr...

Embodiment 2

[0127] 120 parts of Rehmannia glutinosa, 60 parts of wine cornus, 45 parts of Moutan bark, 60 parts of Chinese yam, 45 parts of Poria cocos, 45 parts of Alisma;

[0128] (1) Take raw material Rehmannia glutinosa, wine cornus, Cortex Moutan, Chinese yam, Poria cocos, Alisma, by weight proportioning, for subsequent use;

[0129] (2) Take Moutan cortex and grind it into granules, and put it in CO 2 The volatile oil is extracted in a supercritical extraction kettle, where the pressure is 35Mpa, the temperature of the extraction kettle is 50°C, and the CO 2 The flow rate is 16L / h, the extraction time is 2 hours, and the angelica volatile oil (I) is collected for later use; the remaining medicinal residues are reflux extracted twice with 80% ethanol with a concentration of 6 times, the first time is 1 hour, and the second time is 2 hours , collect the reflux liquid and filter, recover ethanol until there is no alcohol smell, add hot water twice the amount of the original medicinal ...

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Abstract

The invention relates to a preparation method of a concentrated six-taste glutinous rehmannia capsule. In the preparation method, after moutan bark is extracted by using a supercutical fluid, dregs of a decoction are precipitated by using ethanol extraction water; Fructus Corni is extracted by using ethanol and purified by using macroporous resin after being crushed; moutan bark volatile oil is subjected to clathration by using cyclodextrin; prepared rehmannia root, Poria cocos and rhizoma alismatis are decocted in water and precipitated by using ethanol. The concentrated six-taste glutinous rehmannia capsule prepared by the process is good in treatment effect, the preparation is stable and side effects are less.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and in particular relates to a method for preparing concentrated Liuwei Dihuang Capsules, which have the function of nourishing yin and tonifying the kidney, and are used for dizziness, tinnitus, soreness of the waist and knees, hot flashes due to bone steaming, and night sweats and spermatorrhea. Background technique [0002] Liuwei Dihuang is an ancient famous medicine for nourishing yin and tonifying kidney in Chinese medicine. It is composed of rehmannia glutinosa, yam, dogwood, Alisma, Moutan cortex, and Poria cocos. . Qian Yi, a famous doctor in the Song Dynasty, removed the cinnamon twigs and aconite from the kidney qi (Guifu Dihuang) capsule in Zhang Zhongjing's "Synopsis of the Golden Chamber", and kept the six herbs of rehmannia glutinosa, dogwood, yam, peony bark, Poria cocos, and Alisma. The original prescription mainly treats the "five delays" in children, and is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61K9/48A61P1/14A61P1/08A61P27/16A61P19/08A61P29/00A61P15/00A61P13/12A61P1/02A61P3/10A61P17/00
Inventor 余中华
Owner 余中华
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